Rap1GAP regulates renal cell carcinoma invasion.
Gainesville, United States. In Cancer Lett, 2012
Over-expression of Rap1GAP attenuated levels of both cadherins and integrins that are known to regulate the cancer cells invasion in renal cel carcinoma.
The GTPase-activating protein Rap1GAP uses a catalytic asparagine.
Dortmund, Germany. In Nature, 2004
Here we present the crystal structure of the catalytic domain of the Rap1-specific Rap1GAP at 2.9 A. By mutational analysis, fluorescence titration and stopped-flow kinetic assay, we demonstrate that Rap1GAP provides a catalytic asparagine to stimulate GTP hydrolysis.
Return of the GDI: the GoLoco motif in cell division.
Chapel Hill, United States. In Annu Rev Biochem, 2003
The GoLoco motif is present as an independent element within multidomain signaling regulators, such as Loco, RGS12, RGS14, and Rap1GAP, as well as in tandem arrays in proteins, such as AGS3, G18, LGN, Pcp-2/L7, and Partner of Inscuteable (Pins/Rapsynoid).