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RAP1A, member of RAS oncogene family

Rap1, Rap1A, Rap1p
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, V1a, HAD, RAP
Papers using Rap1 antibodies
The Par polarity complex regulates Rap1- and chemokine-induced T cell polarization
Supplier
Collard John G. et al., In The Journal of Cell Biology, 2005
... Antibodies against PKCζ, Tiam1 (C16), Cdc42 (P1), GST, RhoA, and Rap1 were purchased from Santa Cruz Biotechnology, Inc ...
Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors
Supplier
Cooper Jonathan A. et al., In The Journal of Cell Biology, 1998
... pEGFP-17N Rap1a and pEGFP-63E Rap1a were made by subcloning BamHI fragments from pCGN-HA-Rap1a into pEGFP-C1 (CLONTECH Laboratories, Inc.) linearized with ...
A giant nucleopore protein that binds Ran/TC4
Supplier
Bos Johannes L. et al., In The Journal of Cell Biology, 1994
... following antibodies were used: mouse monoclonal GFP (Roche), Flag M2 (Sigma-Aldrich), rabbit polyclonal RanBP2 (Abcam), Rap1 (Santa Cruz Biotechnology, Inc.), and Ran (BD) ...
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
Supplier
Linden Rafael, In PLoS ONE, 1984
... Anti-Rap1 polyclonal Ab (sc-65) was from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Papers on Rap1
Epigenetic Regulation of the Blimp-1 Gene in B Cells Involves Bach2 and Histone Deacetylase 3.
New
Igarashi et al., Japan. In J Biol Chem, Feb 2016
Purification of Bach2 complex in BAL17 cells revealed its interaction with histone deacetylase 3 (HDAC3), nuclear co-repressors NCoR1 and NCoR2, transducin beta-like 1X-linked (Tbl1x), and RAP1 interacting factor homolog (Rif1).
Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein-Protein Interaction in the Shelterin Complex.
New
Wang et al., Ann Arbor, United States. In J Med Chem, Feb 2016
Repressor activator protein 1 (RAP1) and telomeric repeat-binding factor 2 (TRF2) are two subunits in shelterin that interact with each other.
A higher-order entity formed by the flexible assembly of RAP1 with TRF2.
New
Le Du et al., Gif-sur-Yvette, France. In Nucleic Acids Res, Feb 2016
Within shelterin, RAP1 is recruited through its interaction with TRF2, and TRF2 is required for telomere protection through a network of nucleic acid and protein interactions.
TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection.
New
Giraud-Panis et al., Nice, France. In Mol Cell, Feb 2016
In Top-less cells, the protection against NHEJ is alleviated if the expression of the TRF2-interacting protein RAP1 is reduced.
Conserved and unique features of the homeologous maize Aux/IAA proteins ROOTLESS WITH UNDETECTABLE MERISTEM 1 and RUM1-like 1.
New
Hochholdinger et al., Fuzhou, China. In J Exp Bot, Jan 2016
While RUM1 and RUL1 display conserved biochemical properties, yeast-two-hybrid in combination with BiFC experiments identified a RUM1-associated protein 1 (RAP1) that specifically interacts with RUM1 but not with RUL1.
Structures of Ras superfamily effector complexes: What have we learnt in two decades?
Review
New
Owen et al., Cambridge, United Kingdom. In Crit Rev Biochem Mol Biol, Mar 2015
The first structure of a small G protein-effector complex, that of Rap1A with c-Raf1, was published 20 years ago.
Shelterin proteins and cancer.
Review
Trivedi et al., Vellore, India. In Asian Pac J Cancer Prev, 2014
It comprises six proteins, namely TRF1, TRF2, TIN2, POT1, TPP1 and RAP1.
14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins.
Impact
Ridley et al., London, United Kingdom. In Cell, 2013
Rnd1, Rnd2, and geranylgeranylated Rap1A interact similarly with 14-3-3.
Sustained Rap1 activation in autoantigen-specific T lymphocytes attenuates experimental autoimmune encephalomyelitis.
GeneRIF
Reedquist et al., Amsterdam, Netherlands. In J Neuroimmunol, 2012
Rap1 activation restricts autoimmune T cell-mediated pathology through enhancing tolerance.
Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1.
GeneRIF
Pendergast et al., Durham, United States. In Sci Signal, 2012
Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1.
Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1).
GeneRIF
Boggon et al., New Haven, United States. In J Biol Chem, 2012
Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1)
Id proteins synchronize stemness and anchorage to the niche of neural stem cells.
Impact
Lasorella et al., New York City, United States. In Nat Cell Biol, 2012
The interrogation of the gene modules directly targeted by Id deletion in NSCs revealed that Id proteins repress bHLH-mediated activation of Rap1GAP, thus serving to maintain the GTPase activity of RAP1, a key mediator of cell adhesion.
Rap1a deficiency modifies cytokine responses and MAPK-signaling in vitro and impairs the in vivo inflammatory response.
GeneRIF
Scheele et al., Freiburg, Germany. In Cell Immunol, 2012
demonstrate that in rap1-deficient T cells, signaling by the ERK and p38 kinases is increased following activation by different stimuli leading to increased intracellular accumulation and secretion of cytokines
Id-1 plays a key role in cell adhesion in neural stem cells through the preservation of RAP1 signaling.
GeneRIF
Chen et al., In Cell Adh Migr, 2012
Id-1 maintains the GTPase activity of Rap1.
Promoter elements regulate cytoplasmic mRNA decay.
Impact
GeneRIF
Choder et al., Haifa, Israel. In Cell, 2012
Rap1p association with target promoter in the nucleus affects the composition of the exported mRNP, which in turn regulates mRNA decay in the cytoplasm.
Wnt/Ca2+ signaling pathway: a brief overview.
Review
De, Calcutta, India. In Acta Biochim Biophys Sin (shanghai), 2011
The non-canonical Wnt signaling pathways are diverse, defined as planer cell polarity pathway, Wnt-RAP1 signaling pathway, Wnt-Ror2 signaling pathway, Wnt-PKA pathway, Wnt-GSK3MT pathway, Wnt-aPKC pathway, Wnt-RYK pathway, Wnt-mTOR pathway, and Wnt/calcium signaling pathway.
Epigenetics and transcriptional control in African trypanosomes.
Review
Rudenko, London, United Kingdom. In Essays Biochem, 2010
brucei RAP1) has been shown to establish a repressive gradient extending from the ES telomere end up to the ES promoter.
Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1.
Review
Holz et al., Syracuse, United States. In Vitam Horm, 2009
Provided here is an overview of the Epac2 signal transduction system in β cells, with special emphasis on Rap1, a Ras-related GTPase that is an established target of Epac2.
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Impact
Harper et al., Boston, United States. In Cell, 2009
Human SLX4 forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94.
RAP1 is essential for silencing telomeric variant surface glycoprotein genes in Trypanosoma brucei.
Impact
Li et al., Cleveland, United States. In Cell, 2009
Trypanosoma brucei expresses variant surface glycoprotein (VSG) genes in a strictly monoallelic fashion in its mammalian hosts, but it is unclear how this important virulence mechanism is enforced.
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