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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Tumor necrosis factor receptor superfamily, member 11a, NFKB activator

RANK, Receptor Activator of Nuclear Factor-kappa B, FeO
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Studies of the mouse counterpart suggest that this receptor directly mediates the osteoprotegerin ligand (OPGL)-induced osteoclastogenesis in osteoclast precursor cells. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, V1a, CAN, HAD, NFATC
Papers using RANK antibodies
Immature dendritic cell transdifferentiation into osteoclasts: a novel pathway sustained by the rheumatoid arthritis microenvironment
Supplier
Marceau Andrée-Anne et al., In Arthritis Research & Therapy, 2003
... The goat polyclonal anti-human RANK-L immunoglobulin (Ig) G antibody (Ab) (sc-7627) was purchased from Santa Cruz Biotechnology, Inc ...
Papers on RANK
OSCAR-collagen signaling in monocytes plays a pro-inflammatory role and may contribute to the pathogenesis of rheumatoid arthritis.
New
Panina et al., Denmark. In Eur J Immunol, Feb 2016
OSCAR-collagen interaction stimulates RANK-dependent osteoclastogenesis.
Importance of osteoprotegrin and receptor activator of nuclear factor κB in breast cancer response to hepatocyte growth factor and the bone microenvironment in vitro.
New
Jiang et al., Cardiff, United Kingdom. In Int J Oncol, Feb 2016
UNASSIGNED: Osteoprotegrin (OPG), receptor activator of nuclear factor κB (RANK) and RANK ligand (RANKL) are signal transducers which have pleiotropic actions.
Auricular ossification: A newly recognized feature of osteoprotegerin-deficiency juvenile Paget disease.
New
Whyte et al., Saint Louis, United States. In Am J Med Genet A, Feb 2016
JPD2 results from heterozygous constitutive activation of TNFRSF11A encoding RANK.
RANK-RANKL interactions are involved in cell adhesion-mediated drug resistance in multiple myeloma cell lines.
New
Nishida et al., Ōsaka, Japan. In Tumour Biol, Feb 2016
Recently, it has been reported that MM cells express the receptor activator of nuclear factor-κB (NF-κB) (RANK).
Rank as a therapeutic target in cancer.
Review
New
Sanz-Moreno et al., Barcelona, Spain. In Febs J, Feb 2016
UNASSIGNED: RANK signaling pathway has emerged as a new target in breast cancer as RANKL and its receptor, RANK, mediate the protumorigenic role of progesterone in the mammary gland.
Characterization and application of two RANK-specific antibodies with different biological activities.
New
Mueller et al., Strasbourg, France. In Immunol Lett, Feb 2016
The TNF-family member Receptor Activator of NF-κB (RANK) is known for its role in bone homeostasis and is increasingly recognized as a central player in immune regulation and epithelial cell activation.
Bacterial ferrous iron transport: the Feo system.
Review
New
Vogel et al., Calgary, Canada. In Fems Microbiol Rev, Jan 2016
Several bacterial ferrous iron transport systems have been described; however, only the Feo system appears to be widely distributed and is exclusively dedicated to the transport of iron.
Melatonin, bone regulation and the ubiquitin-proteasome connection: A review.
Review
New
Reiter et al., Winnipeg, Canada. In Life Sci, Jan 2016
The major signal transduction pathways regulating bone formation are the RANK/NF-κB pathway and the Wnt/β-catenin pathway.
Medication Related Osteonecrosis of the Jaw: 2015 Position Statement of the Korean Society for Bone and Mineral Research and the Korean Association of Oral and Maxillofacial Surgeons.
Review
New
Kim et al., Seoul, South Korea. In J Bone Metab, Nov 2015
In the revised edition, the diagnosis BRONJ was changed to medication-related ONJ (MRONJ), which reflects a consideration of the fact that ONJ also occurs for denosumab, a bone resorption inhibitor of the receptor activator of nuclear factor-kappa B ligand (RANKL) antibody family, and bevacizumab, an anti-angiogenesis inhibitor.
Adjuvant denosumab in breast cancer (ABCSG-18): a multicentre, randomised, double-blind, placebo-controlled trial.
New
Impact
Austrian Breast and Colorectal Cancer Study Group et al., Vienna, Austria. In Lancet, Sep 2015
In this trial, we aimed to investigate the effects of the anti-RANK ligand antibody denosumab in postmenopausal, aromatase inhibitor-treated patients with early-stage hormone receptor-positive breast cancer.
Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway.
New
Impact
Vasavada et al., New York City, United States. In Cell Metab, Aug 2015
Mechanistically, osteoprotegerin induced human and rodent β-cell replication by modulating CREB and GSK3 pathways, through binding Receptor Activator of NF-κB (RANK) Ligand (RANKL), a brake in β-cell proliferation.
The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.
New
Impact
Erler et al., Copenhagen, Denmark. In Nature, Jul 2015
We identify LOX as a novel regulator of NFATc1-driven osteoclastogenesis, independent of RANK ligand, which disrupts normal bone homeostasis leading to the formation of focal pre-metastatic lesions.
Bone resorption: an actor of dental and periodontal development?
Review
Lézot et al., Paris, France. In Front Physiol, 2014
In the last decade, consequences of bone resorption over-activation on dental and periodontal tissue formation have been analyzed with transgenic animals (RANK (Tg) and Opg (-∕-) mice).
Deep penetration of molten iron into the mantle caused by a morphological instability.
Impact
Karato et al., New Haven, United States. In Nature, 2013
More fundamentally, experimental studies and geophysical observations show that the core is under-saturated with oxygen, implying that the mantle next to the core should be depleted in FeO.
c-Src links a RANK/αvβ3 integrin complex to the osteoclast cytoskeleton.
GeneRIF
Teitelbaum et al., Saint Louis, United States. In Mol Cell Biol, 2012
activated RANK prompts two distinct signaling pathways; one promotes osteoclast formation, and the other, in collaboration with c-Src-mediated linkage to alphavbeta3, organizes the cell's cytoskeleton
RANK (TNFRSF11A) is epigenetically inactivated and induces apoptosis in gliomas.
GeneRIF
Waha et al., Bonn, Germany. In Neoplasia, 2012
We conclude that RANK/TNFRSF11A is a novel and frequent target for de novo methylation in gliomas, which affects apoptotic activity and focus formation thereby contributing to the molecular pathogenesis of gliomas.
Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab.
Review
Impact
Dansey et al., San Francisco, United States. In Nat Rev Drug Discov, 2012
This Review chronicles the events that led to an increased understanding of bone resorption, the elucidation of the signalling pathway mediated by osteoprotegerin, receptor activator of NF-κB (RANK) and RANK ligand (RANKL) and its role in osteoclast biology, as well as the evolution of recombinant RANKL antagonists, which culminated in the development of the therapeutic RANKL-targeted antibody denosumab.
Human polymorphonuclear neutrophils express RANK and are activated by its ligand, RANKL.
GeneRIF
Hänsch et al., Heidelberg, Germany. In Eur J Immunol, 2012
regulated RANK expression contributes to the fine tuning of PMN migration, for example, on and through inflamed endothelium that is known to express RANKL.
Association between OPG, RANK and RANKL gene polymorphisms and susceptibility to acute coronary syndrome in Korean population.
GeneRIF
Kim et al., Seoul, South Korea. In J Genet, 2011
Genetic variations using representative single nucleotide polymorphisms (SNPs) of OPG (rs2073618), RANK (rs1805034) and RANKL (rs2073618), were analysed.
Identification of novel human receptor activator of nuclear factor-kB isoforms generated through alternative splicing: implications in breast cancer cell survival and migration.
GeneRIF
Kalofonos et al., In Breast Cancer Res, 2011
Novel RANK variants, providing evidence of a complex regulatory pathway for RANK receptor signaling, with possible implications in various systems, tissues and cells.
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