Rank as a therapeutic target in cancer.
Barcelona, Spain. In Febs J, Feb 2016
UNASSIGNED: RANK signaling pathway has emerged as a new target in breast cancer as RANKL and its receptor, RANK, mediate the protumorigenic role of progesterone in the mammary gland.
Bacterial ferrous iron transport: the Feo system.
Calgary, Canada. In Fems Microbiol Rev, Jan 2016
Several bacterial ferrous iron transport systems have been described; however, only the Feo system appears to be widely distributed and is exclusively dedicated to the transport of iron.
Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab.
San Francisco, United States. In Nat Rev Drug Discov, 2012
This Review chronicles the events that led to an increased understanding of bone resorption, the elucidation of the signalling pathway mediated by osteoprotegerin, receptor activator of NF-κB (RANK) and RANK ligand (RANKL) and its role in osteoclast biology, as well as the evolution of recombinant RANKL antagonists, which culminated in the development of the therapeutic RANKL-targeted antibody denosumab.