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RAN binding protein 9

RanBPM, RanBP9
This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RAN, importin 9, CAN, APP, GST
Papers using RanBPM antibodies
Novel role of the muskelin–RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation
Supplier
Adams Josephine C. et al., In The Journal of Cell Biology, 2002
... Goat anti-RanBP9 was obtained from Abcam.
Papers on RanBPM
The CCDC55 couples cannabinoid receptor CNR1 to a putative DISC1 schizophrenia pathway.
New
Leopardi et al., Stockholm, Sweden. In Neuroscience, Jan 2016
PRINCIPAL FINDINGS: (i) CCDC55 is expressed as a nuclear protein in human neuronal cells; (ii) Protein-protein interaction analyses showed CCDC55 physically interacted with Ran binding protein 9 (RanBP9) and disrupted in schizophrenia 1 (DISC1); (iii) CCDC55 and RanBP9 co-localized in the nucleus of human neuronal cells; (iv) CCDC55 also interacted with the cannabinoid receptor 1 (CNR1), and with the brain cannabinoid receptor-interacting protein 1a (CNRIP1a); (v) CNR1 activation in differentiated human neuronal cells resulted in an altered RanBP9 localization.
RanBPM regulates Zta-mediated transcriptional activity in Epstein-Barr virus.
New
Chang et al., Taipei, Taiwan. In J Gen Virol, Aug 2015
Our previous research indicated that RanBPM interacts with Rta and enhances Rta sumoylation.
COPS5 protein overexpression increases amyloid plaque burden, decreases spinophilin-immunoreactive puncta, and exacerbates learning and memory deficits in the mouse brain.
New
Lakshmana et al., Port Saint Lucie, United States. In J Biol Chem, May 2015
We demonstrated previously that COPS5 regulates Aβ generation in neuronal cell lines in a RanBP9-dependent manner.
Gene expression ontogeny of spermatogenesis in the marmoset uncovers primate characteristics during testicular development.
New
Okano et al., Tokyo, Japan. In Dev Biol, May 2015
We then explored the expression of a set of markers, including PIWIL1/MARWI, VASA, DAZL, CLGN, RanBPM, SYCP1 and HAPRIN, during germ cell differentiation from early spermatocytes through round and elongating spermatids, and a clear program of gene expression changes was determined as development proceeded.
Investigating the potential genetic association between RANBP9 polymorphisms and the risk of schizophrenia.
New
Woo et al., Seoul, South Korea. In Mol Med Report, Apr 2015
The gene for human Ran‑binding protein 9 (RANBP9) is a newly discovered candidate gene for schizophrenia.
RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction.
Kang et al., Tampa, United States. In Cell Death Dis, 2014
We recently found that overexpression of the scaffolding protein RanBP9 increases Aβ production in cell lines and in transgenic mice while promoting cofilin activation and mitochondrial dysfunction.
RAN-binding protein 9 is involved in alternative splicing and is critical for male germ cell development and male fertility.
Yan et al., Reno, United States. In Plos Genet, 2014
As a member of the large Ran-binding protein family, Ran-binding protein 9 (RANBP9) has been suggested to play a critical role in diverse cellular functions in somatic cell lineages in vitro, and this is further supported by the neonatal lethality phenotype in Ranbp9 global knockout mice.
Characterization of RanBPM molecular determinants that control its subcellular localization.
Schild-Poulter et al., London, Canada. In Plos One, 2014
RanBPM/RanBP9 is a ubiquitous, nucleocytoplasmic protein that is part of an evolutionary conserved E3 ubiquitin ligase complex whose function and targets in mammals are still unknown.
Identification of Ran-binding protein M as a stanniocalcin 2 interacting protein and implications for androgen receptor activity.
Sohn et al., Kangnŭng, South Korea. In Bmb Rep, 2014
In this study, we identified Ran-binding protein M (RanBPM) as a novel binding partner of STC2 using yeast two-hybrid screening.
RanBP9 overexpression accelerates loss of dendritic spines in a mouse model of Alzheimer's disease.
Lakshmana et al., Port Saint Lucie, United States. In Neurobiol Dis, 2014
We previously demonstrated that RanBP9 overexpression increased Aβ generation and amyloid plaque burden, subsequently leading to robust reductions in the levels of several synaptic proteins as well as deficits in the learning and memory skills in a mouse model of Alzheimer's disease (AD).
RanBP9 modulates AICD localization and transcriptional activity via direct interaction with Tip60.
da Cruz E Silva et al., Aveiro, Portugal. In J Alzheimers Dis, 2013
Here we report that RanBP9 interacts with the cytoplasmic domain of AβPP, through the NPXY internalization motif.
RanBPM, a scaffolding protein for gametogenesis.
Review
Tessarollo et al., Frederick, United States. In Curr Top Dev Biol, 2012
RanBPM is a multimodular scaffold protein that interacts with a great variety of molecules including nuclear, cytoplasmic, and membrane proteins.
Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain.
GeneRIF
Kang et al., Port Saint Lucie, United States. In Faseb J, 2012
increased Abeta levels by RanBP9 observed in the present study provides compelling evidence that RanBP9 may indeed play a key role in the etiology of AD
Pivotal role of RanBP9 in integrin-dependent focal adhesion signaling and assembly.
GeneRIF
Kang et al., Seoul, South Korea. In Faseb J, 2012
Data indicate that RanBP9 simultaneously inhibits cell-adhesive processes and enhances Abeta generation by accelerating APP, LRP, and beta1-integrin endocytosis.
Diverse roles of the scaffolding protein RanBPM.
Review
Baek et al., Seoul, South Korea. In Drug Discov Today, 2012
Ran-binding protein microtubule-organizing center (RanBPM) appears to function as a scaffolding protein in several signal transduction pathways.
The Ran-binding protein RanBPM can depress the NF-κB pathway by interacting with TRAF6.
GeneRIF
Huang et al., Beijing, China. In Mol Cell Biochem, 2012
RanBPM influences TRAF6 ubiquitination and the TRAF6-triggered NF-kappaB signaling pathway through RanBPM's interaction with TRAF6. These data suggest that RanBPM participates in gene transcription by binding to TRAF6.
RanBPM is essential for mouse spermatogenesis and oogenesis.
GeneRIF
Tessarollo et al., Frederick, United States. In Development, 2011
show that RanBPM is essential for normal gonad development as both male and female RanBPM(-/-) mice are sterile
Stability and function of mammalian lethal giant larvae-1 oncoprotein are regulated by the scaffolding protein RanBPM.
GeneRIF
Baek et al., Seoul, South Korea. In J Biol Chem, 2010
Findings reveal that RanBPM plays a novel role in regulating Mgl-1 stability and contributes to its biological function as a tumor suppressor.
RanBPM, a scaffolding protein in the immune and nervous systems.
Review
GeneRIF
Talbot et al., Omaha, United States. In J Neuroimmune Pharmacol, 2007
Studies in this review indicate that RanBPM acts as a scaffolding protein and is important in regulating cellular function in both the immune system and the nervous system.
A new role of ran GTPase.
Review
Nishimoto, Fukuoka, Japan. In Biochem Biophys Res Commun, 1999
A recently found novel Ran-binding protein, RanBPM, however, is localized in the centrosome.
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