The CCDC55 couples cannabinoid receptor CNR1 to a putative DISC1 schizophrenia pathway.
Stockholm, Sweden. In Neuroscience, Jan 2016
PRINCIPAL FINDINGS: (i) CCDC55 is expressed as a nuclear protein in human neuronal cells; (ii) Protein-protein interaction analyses showed CCDC55 physically interacted with Ran binding protein 9 (RanBP9) and disrupted in schizophrenia 1 (DISC1); (iii) CCDC55 and RanBP9 co-localized in the nucleus of human neuronal cells; (iv) CCDC55 also interacted with the cannabinoid receptor 1 (CNR1), and with the brain cannabinoid receptor-interacting protein 1a (CNRIP1a); (v) CNR1 activation in differentiated human neuronal cells resulted in an altered RanBP9 localization.
Gene expression ontogeny of spermatogenesis in the marmoset uncovers primate characteristics during testicular development.
Tokyo, Japan. In Dev Biol, May 2015
We then explored the expression of a set of markers, including PIWIL1/MARWI, VASA, DAZL, CLGN, RanBPM, SYCP1 and HAPRIN, during germ cell differentiation from early spermatocytes through round and elongating spermatids, and a clear program of gene expression changes was determined as development proceeded.
RanBPM, a scaffolding protein for gametogenesis.
Frederick, United States. In Curr Top Dev Biol, 2012
RanBPM is a multimodular scaffold protein that interacts with a great variety of molecules including nuclear, cytoplasmic, and membrane proteins.
A new role of ran GTPase.
Fukuoka, Japan. In Biochem Biophys Res Commun, 1999
A recently found novel Ran-binding protein, RanBPM, however, is localized in the centrosome.