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RAMP1, receptor activity-modifying protein 1
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Calcitonin, adrenomedullin, calcitonin receptor-like receptor, CAN, HAD
Papers on RAMP1
Amylin receptor components and the leptin receptor are co-expressed in single rat area postrema neurons.
Lutz et al., Zürich, Switzerland. In Eur J Neurosci, Feb 2016
AMY are heterodimers that include a calcitonin receptor (CTR) subunit (CTRa or CTRb) and a member of the receptor activity modifying proteins (RAMPs).
Synovial macrophage-derived IL-1β regulates the calcitonin receptor in osteoarthritic mice.
Takaso et al., Sagamihara, Japan. In Clin Exp Immunol, Jan 2016
Real-time polymerase chain reaction (PCR) was used to evaluate the expression of interleukin (IL)-1β, CGRP, calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in F4/80(+) and F4/80(-) cells.
Role of extracellular calcitonin gene-related peptide in spinal cord mechanisms of cancer-induced bone pain.
Malcangio et al., London, United Kingdom. In Pain, Dec 2015
CGRP receptor components (CLR and RAMP1) were up-regulated in dorsal horn neurons and expressed by reactive astrocytes.
[Impact and related mechanism of exogenous receptor activity modifying protein 1 on calcitonin gene-related peptide modified bone marrow mesenchymal stem cells on the migration of vascular smooth muscle cells in vitro].
Shi et al., Zunyi, China. In Zhonghua Xin Xue Guan Bing Za Zhi, Jun 2015
METHODS: The MSC and VSMC were isolated from rats and cultured, CGRP was transfected to MSC with the high expression lentivirus vector, VSMC was transfected with high expression lentivirus vector of receptor activity modifying protein 1 (RAMP1) and the silence expression lentivirus vector of RAMP1.
Kynurenic acid modulates experimentally induced inflammation in the trigeminal ganglion.
Warfvinge et al., Szeged, Hungary. In J Headache Pain, 2014
We investigated changes of mitogen-activated protein kinases (MAPKs as ERK1/2, p38 and SAPK/JNK), NF-κB, CaMKII and DREAM, in addition to calcitonin gene-related peptide (CGRP) and its receptor components calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in the TG, with immunohistochemistry and Western blot at 2 and 10 days post-CFA injection.
DNA methylation of RAMP1 gene in migraine: an exploratory analysis.
Yu et al., Beijing, China. In J Headache Pain, 2014
BACKGROUND: Receptor activity modifying protein 1(RAMP1) is a key receptor subunit of calcitonin gene related peptide (CGRP) playing a critical role in migraine.
CGRP and migraine: could PACAP play a role too?
Russo et al., Iowa City, United States. In Neuropeptides, 2013
Interestingly, both CGRP and PACAP act on receptors that share an accessory subunit called receptor activity modifying protein-1 (RAMP1).
Functions of third extracellular loop and helix 8 of Family B GPCRs complexed with RAMPs and characteristics of their receptor trafficking.
Kato et al., Miyazaki, Japan. In Curr Protein Pept Sci, 2013
At least one of three receptor activity-modifying proteins (RAMP1, RAMP2 and RAMP3) can interact with 10 G protein-coupled receptors (GPCRs; nine Family B GPCRs and a Family C GPCR).
CGRP receptor antagonism and migraine therapy.
Warfvinge et al., Lund, Sweden. In Curr Protein Pept Sci, 2013
The CGRP receptor consists of a complex of calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1) and receptor component protein (RCP).
Ectodomain structures of the CGRP and AM receptors.
Yokoyama et al., Yokohama, Japan. In Curr Protein Pept Sci, 2013
Receptor activity-modifying proteins (RAMPs) 1-3, which are classified as type I transmembrane proteins, serve as the partner proteins of several family B GPCRs for physiologically active peptides, including the calcitonin receptor- like receptor (CLR).
Comparing the molecular pharmacology of CGRP and adrenomedullin.
Conner et al., Warwick, United Kingdom. In Curr Protein Pept Sci, 2013
For CGRP this is receptor activity-modifying protein 1 [RAMP1] and for AM acting at the AM1 receptor this is RAMP2.
Deficiency of the CGRP receptor component RAMP1 attenuates immunosuppression during the early phase of septic peritonitis.
Holzmann et al., München, Germany. In Immunobiology, 2012
Data indicate that the lack of an intact CGRP receptor component RAMP1 resulted in an increased recruitment and activation of neutrophils.
Localization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract.
Bhargava et al., San Francisco, United States. In Peptides, 2012
CLR and RAMP1 co-localize in the enteric nervous system of human stomach, ileum, and colon, and are in close proximity to their ligands CGRP and IMD
Calcitonin gene-related peptide and its receptor components in the human sphenopalatine ganglion -- interaction with the sensory system.
Warfvinge et al., Szeged, Hungary. In Brain Res, 2012
The present finding demonstrated that RAMP1 immunoreactivity was localized in many neurons and phenopalatine ganglion.
Intermedin stabilized endothelial barrier function and attenuated ventilator-induced lung injury in mice.
Witzenrath et al., Berlin, Germany. In Plos One, 2011
Data show that mechanical ventilation reduced the expression of receptor activity-modifying protein RAMP3, but not of intermedin (IMD), calcitonin receptor-like receptor (CRLR), and RAMP1 and RAMP2.
Suppression of ovalbumin-induced allergic diarrhea by diminished intestinal peristalsis in RAMP1-deficient mice.
Tsujikawa et al., Suita, Japan. In Biochem Biophys Res Commun, 2011
significantly diminished intestinal peristalsis was observed by the allergy induction in RAMP1-deficient mice compared with WT mice.
International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor.
International Union of Pharmacology et al., Birmingham, United Kingdom. In Pharmacol Rev, 2008
After the cloning of calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs), it became clear that the CGRP(1) receptor was a complex between CLR and RAMP1.
Vascular actions of calcitonin gene-related peptide and adrenomedullin.
Grant et al., London, United Kingdom. In Physiol Rev, 2004
The association of CL with RAMP1 produces a CGRP receptor, with RAMP2 an AM receptor and with RAMP3 a CGRP/AM receptor.
International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors.
Foord et al., Birmingham, United Kingdom. In Pharmacol Rev, 2002
The calcitonin-like receptor (CL receptor) requires a single transmembrane domain protein, termed receptor activity modifying protein, RAMP1, to function as a CGRP receptor.
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.
Foord et al., Stevenage, United Kingdom. In Nature, 1998
RAMP1 presents the receptor at the cell surface as a mature glycoprotein and a CGRP receptor.
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