Aldehyde dehydrogenase 1A1 in stem cells and cancer.
Gifu, Japan. In Oncotarget, Feb 2016
ALDH1 has three main isotypes, ALDH1A1, ALDH1A2, and ALDH1A3, and is a marker of normal tissue stem cells (SC) and cancer stem cells (CSC), where it is involved in self-renewal, differentiation and self-protection.
Induction of Functional 3D Ciliary Epithelium-Like Structure From Mouse Induced Pluripotent Stem Cells.
Nagasaki, Japan. In Invest Ophthalmol Vis Sci, Feb 2016
Connexin43 and aquaporin1 were expressed in both thin layers, and induced CE-like cells expressed ciliary marker genes, such as cyclinD2, zic1, tgfb2, aldh1a3, wfdc1, otx1, BMP4, and BMP7.
Evidence of β-cell Dedifferentiation in Human Type 2 Diabetes.
Ancona, Italy. In J Clin Endocrinol Metab, Jan 2016
DESIGN: We scored dedifferentiation using markers of endocrine lineage, β cell-specific transcription factors, and a newly identified endocrine progenitor cell marker, aldehyde dehydrogenase 1A3 (ALDH1A3).
Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment.
Ames, United States. In Heredity (edinb), Dec 2015
In particular, selection signatures spanning several genes that directly or indirectly influenced traits for adaptation to hot arid environments, such as thermo-tolerance (melanogenesis) (FGF2, GNAI3, PLCB1), body size and development (BMP2, BMP4, GJA3, GJB2), energy and digestive metabolism (MYH, TRHDE, ALDH1A3), and nervous and autoimmune response (GRIA1, IL2, IL7, IL21, IL1R1) were identified.
Genome-wide methylation profiling reveals new biomarkers for prognosis prediction of glioblastoma.
Kaifeng, China. In J Cancer Res Ther, Oct 2015
Of these, we selected 10 most hypermethylated genes, including IL11, RRAD, MS4A6A, SNAPC2, ALDH1A3, ADCY1, MMS19L, NDUFB8, POMC, and THSD4, to perform cluster analysis.
The genetic architecture of microphthalmia, anophthalmia and coloboma.
Edinburgh, United Kingdom. In Eur J Med Genet, 2014
This review will focus on MAC phenotypes that are associated with mutation of the genes SOX2, OTX2, PAX6, STRA6, ALDH1A3, RARB, VSX2, RAX, FOXE3, BMP4, BMP7, GDF3, GDF6, ABCB6, ATOH7, C12orf57, TENM3 (ODZ3), and VAX1.