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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Aldehyde dehydrogenase family 1, subfamily A3

Raldh3, ALDH1A3, ALDH6, aldehyde dehydrogenase 6
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this gene uses retinal as a substrate, either in a free or cellular retinol-binding protein form. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Aldehyde Dehydrogenase, CAN, HAD, CYP26A1
Papers on Raldh3
ALDH Enzyme Expression Is Independent of the Spermatogenic Cycle, and Their Inhibition Causes Misregulation of Murine Spermatogenic Processes.
Griswold et al., Pullman, United States. In Biol Reprod, 31 Dec 2016
Here, we show via various quantitative methods that the three well-known ALDH enzymes (ALDH1A1, ALDH1A2, and ALDH1A3), and an ALDH enzyme previously unreported in the murine testis (ALDH8A1), are not expressed in a stage-specific manner in the adult testis, but do fluctuate throughout juvenile development in perfect agreement with the first appearance of each advancing germ cell type.
Aldehyde dehydrogenase 1A1 in stem cells and cancer.
Hara et al., Gifu, Japan. In Oncotarget, Feb 2016
ALDH1 has three main isotypes, ALDH1A1, ALDH1A2, and ALDH1A3, and is a marker of normal tissue stem cells (SC) and cancer stem cells (CSC), where it is involved in self-renewal, differentiation and self-protection.
Induction of Functional 3D Ciliary Epithelium-Like Structure From Mouse Induced Pluripotent Stem Cells.
Takahashi et al., Nagasaki, Japan. In Invest Ophthalmol Vis Sci, Feb 2016
Connexin43 and aquaporin1 were expressed in both thin layers, and induced CE-like cells expressed ciliary marker genes, such as cyclinD2, zic1, tgfb2, aldh1a3, wfdc1, otx1, BMP4, and BMP7.
Evidence of β-cell Dedifferentiation in Human Type 2 Diabetes.
Accili et al., Ancona, Italy. In J Clin Endocrinol Metab, Jan 2016
DESIGN: We scored dedifferentiation using markers of endocrine lineage, β cell-specific transcription factors, and a newly identified endocrine progenitor cell marker, aldehyde dehydrogenase 1A3 (ALDH1A3).
Human articular chondrocytes with higher aldehyde dehydrogenase activity have stronger expression of COL2A1 and SOX9.
Christian et al., Vilnius, Lithuania. In Osteoarthritis Cartilage, Jan 2016
Genes of isoenzymes ALDH1A2, ALDH1A3 and ALDH2 were strongly expressed, while ALDH1A1 was weakly expressed in chondrocytes.
ALDH(+)/CD44(+) cells in breast cancer are associated with worse prognosis and poor clinical outcome.
Ye et al., Chengdu, China. In Exp Mol Pathol, Jan 2016
MATERIALS AND METHODS: We investigated the prevalence of ALDH1A3(+)/CD44(+) cells in a cohort of 144 formalin-fixed, paraffin-embedded (FFPE) breast cancer tissues.
Aldehyde dehydrogenases and cancer stem cells.
Wang et al., Hangzhou, China. In Cancer Lett, Jan 2016
Thus, this review focuses on the function and regulation of ALDHs in CSCs, particularly ALDH1A1 and ALDH1A3.
Analysis of crosstalk between retinoic acid and sonic hedgehog pathways following ethanol exposure in embryonic zebrafish.
Cole et al., Durham, United States. In Birth Defects Res A Clin Mol Teratol, Dec 2015
METHODS: Zebrafish embryos were exposed to ethanol in the absence or presence of aldh1a3 or Shh morpholino oligonucleotides (MOs), which disrupt retinoic acid (RA) or sonic hedgehog (Shh) function, respectively.
Retinoic acid and retinaldehyde dehydrogenase are not involved in the specific induction of the follicle-stimulating hormone β subunit by trichostatin A, a selective inhibitor of histone deacetylase.
Kyo et al., Izumo, Japan. In Gen Comp Endocrinol, Dec 2015
Anacardic acid, a histone acetyltransferase inhibitor that prevents histone acetylation, significantly inhibited TSA-induced FSHβ mRNA expression as well as TSA-induced RALDH2 and RALDH3 mRNA expression.
Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment.
Rothschild et al., Ames, United States. In Heredity (edinb), Dec 2015
In particular, selection signatures spanning several genes that directly or indirectly influenced traits for adaptation to hot arid environments, such as thermo-tolerance (melanogenesis) (FGF2, GNAI3, PLCB1), body size and development (BMP2, BMP4, GJA3, GJB2), energy and digestive metabolism (MYH, TRHDE, ALDH1A3), and nervous and autoimmune response (GRIA1, IL2, IL7, IL21, IL1R1) were identified.
Genome-wide methylation profiling reveals new biomarkers for prognosis prediction of glioblastoma.
He et al., Kaifeng, China. In J Cancer Res Ther, Oct 2015
Of these, we selected 10 most hypermethylated genes, including IL11, RRAD, MS4A6A, SNAPC2, ALDH1A3, ADCY1, MMS19L, NDUFB8, POMC, and THSD4, to perform cluster analysis.
Acetaldehyde and retinaldehyde-metabolizing enzymes in colon and pancreatic cancers.
Vasiliou et al., Aurora, United States. In Adv Exp Med Biol, 2014
RA is synthesized from retinaldehyde by the retinaldehyde dehydrogenases, specifically ALDH1A1, ALDH1A2, ALDH1A3, and ALDH8A1.
ALDH1A3: A Marker of Mesenchymal Phenotype in Gliomas Associated with Cell Invasion.
Zhang et al., Beijing, China. In Plos One, 2014
Here, we investigate the clinical significance and potential function of ALDH1A3 in gliomas.
The genetic architecture of microphthalmia, anophthalmia and coloboma.
FitzPatrick et al., Edinburgh, United Kingdom. In Eur J Med Genet, 2014
This review will focus on MAC phenotypes that are associated with mutation of the genes SOX2, OTX2, PAX6, STRA6, ALDH1A3, RARB, VSX2, RAX, FOXE3, BMP4, BMP7, GDF3, GDF6, ABCB6, ATOH7, C12orf57, TENM3 (ODZ3), and VAX1.
Aldehyde dehydrogenase 1A1: friend or foe to female metabolism?
Ziouzenkova et al., Columbus, United States. In Nutrients, 2013
We focus on the characterization of the aldehyde dehydrogenase-1 family of enzymes (ALDH1A1, ALDH1A2, ALDH1A3) that catalyze conversion of retinaldehyde to retinoic acid.
Aldehyde dehydrogenase activity is a biomarker of primitive normal human mammary luminal cells.
Eaves et al., Vancouver, Canada. In Stem Cells, 2012
ALDH1A3 transcripts are detected at high levels in luminal progenitor-enriched fractions obtained from short-term adherent cultures of freshly isolated normal human mammary cells.
Concerted action of aldehyde dehydrogenases influences depot-specific fat formation.
Ziouzenkova et al., Columbus, United States. In Mol Endocrinol, 2011
regulation of fat depots through the concerted action of Aldh1 enzymes establishes retinoic acid-dependent tandem regulation of transcription factors ZFP423 and PPARgamma in a depot-specific manner
Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis.
Lee et al., Halifax, Canada. In Stem Cells, 2011
ALDH1A3 expression in patient breast tumors correlates significantly with tumor grade, metastasis, and cancer stage
Aldehyde dehydrogenase 1A3 is transcriptionally activated by all-trans-retinoic acid in human epidermal keratinocytes.
Tschachler et al., Vienna, Austria. In Biochem Biophys Res Commun, 2010
these results indicate that the regulation of the retinoic acid metabolism in the epidermis involves transcriptional activation of ALDH1A3, possibly representing a positive feedback loop, which enhances the effect of exogenous retinoic acid.
Non-cell-autonomous retinoid signaling is crucial for renal development.
Mendelsohn et al., New York City, United States. In Development, 2010
Raldh2 and Raldh3 are selectively expressed in cortical stroma and in the ureteric bud during kidney development.
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