An Inhibitor of PIDDosome Formation.
New York City, United States. In Mol Cell, Jul 2015
The PIDDosome-PIDD-RAIDD-caspase-2 complex-is a proapoptotic caspase-activation platform of elusive significance.
The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli.
Nashville, United States. In J Biol Chem, 2014
Previously, we reported that BCL10 in immune cells is targeted by the "death" adaptor CRADD/RAIDD (CRADD), which negatively regulates nuclear factor κB (NFκB)-dependent cytokine and chemokine expression in T cells (Lin, Q., Liu, Y., Moore, D. J., Elizer, S. K., Veach, R. A., Hawiger, J., and Ruley, H. E. (2012) J. Immunol.
Caspases: the executioners of apoptosis.
Leicester, United Kingdom. In Biochem J, 1997
The importance of caspase prodomains in the regulation of apoptosis is further highlighted by the recognition of adapter molecules, such as RAIDD [receptor-interacting protein (RIP)-associated ICH-1/CED-3-homologous protein with a death domain]/CRADD (caspase and RIP adapter with death domain), which binds to the prodomain of caspase-2 and recruits it to the signalling complex.
RAIDD is a new 'death' adaptor molecule.
Ann Arbor, United States. In Nature, 1997
Here we describe such an adaptor molecule, RAIDD, which has an unusual bipartite architecture comprising a carboxy-terminal death domain that binds to the homologous domain in RIP, a serine/threonine kinase component of the death pathway.