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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 14 Apr 2015.

Protein phosphatase 1, regulatory subunit 13 like

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, CD38, ZAP-70
Papers on Rai
Prospective validation of predictive value of abdominal computed tomography scan on time to first treatment in rai 0 chronic lymphocytic leukaemia patients: results of the multicenter o-cll1-gisl study.
Morabito et al., Cosenza, Italy. In Eur J Haematol, 09 Apr 2015
METHODS: aCT was performed at diagnosis in 181 Rai 0 patients enrolled in the O-CLL1-GISLtrial (clinicaltrial.
Sorafenib: a review of its use in patients with radioactive iodine-refractory, metastatic differentiated thyroid carcinoma.
Plosker et al., Auckland, New Zealand. In Target Oncol, 31 Mar 2015
Sorafenib (Nexavar®) is the first tyrosine kinase inhibitor to be approved for the treatment of radioactive iodine (RAI)-refractory differentiated thyroid carcinoma (DTC).
Hyperkalemia Develops in Some Thyroidectomized Patients Undergoing Thyroid Hormone Withdrawal in Preparation for Radioactive Iodine Ablation for Thyroid Carcinoma.
Kawakami et al., Nagasaki, Japan. In Endocr Pract, 09 Mar 2015
To study these questions we determined serum potassium (K+) levels in thyroidectomized patients undergoing levothyroxine withdrawal before radioactive iodine (RAI) therapy for thyroid carcinoma.Methods: We retrospectively studied the records of 108 patients who had undergone total thyroidectomy for thyroid carcinoma followed by levothyroxine withdrawal and then ablation with RAI at Nagasaki University Hospital from 2009-2013.
Differentiated thyroid cancer: focus on emerging treatments for radioactive iodine-refractory patients.
Colevas et al., Stanford, United States. In Oncologist, Feb 2015
BACKGROUND: The treatment of differentiated thyroid cancer refractory to radioactive iodine (RAI) had been hampered by few effective therapies.
Increased expression of retinoic acid-induced gene 1 in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression.
Weis et al., Graz, Austria. In Neuropsychiatr Dis Treat, Dec 2014
Retinoic acid-inducible or induced gene 1 (RAI-1) is induced during neuronal differentiation, and was associated with the severity of the phenotype and response to medication in schizophrenic patients.
New Therapies for Dedifferentiated Papillary Thyroid Cancer.
Antonelli et al., Pisa, Italy. In Int J Mol Sci, Dec 2014
Standard treatment usually includes primary surgery, thyroid-stimulating hormone suppressive therapy, and ablation of the thyroid remnant with radioactive iodine (RAI).
ZAP-70 Protein Expression in B-cell Chronic Lymphoid Leukemia: a Single Center Experience from Pakistan.
Bhimani et al., Karāchi, Pakistan. In Asian Pac J Cancer Prev, Dec 2014
The Rai and Binet staging systems have been well recognized as standards for assessing the treatment requirements and overall survival in CLL patients.
Treatment strategies for radioactive iodine-refractory differentiated thyroid cancer.
Worden, Ann Arbor, United States. In Ther Adv Med Oncol, Nov 2014
Until recently, no truly effective treatment options have existed for patients with radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC), a serious disease with poor prognosis.
The current role of targeted therapies to induce radioiodine uptake in thyroid cancer.
Wahl et al., Tübingen, Germany. In Cancer Treat Rev, Jun 2014
Although the mode of action is not clear, the combination of tyrosine kinase inhibitors and RAI treatment could improve clinical responses in non-radioiodine avid metastatic thyroid carcinoma.
Clinical roundtable monograph: unmet needs in the treatment of chronic lymphocytic leukemia: integrating a targeted approach.
Smith et al., In Clin Adv Hematol Oncol, 2014
Although several features can be useful in the diagnosis of CLL, the most important is the immunophenotype.Two staging systems--the Binet system and the Rai classification--are used to assess risk.
Evolving approaches to patients with advanced differentiated thyroid cancer.
Sherman et al., Aurora, United States. In Endocr Rev, 2013
Advanced differentiated thyroid cancer (DTC), defined by clinical characteristics including gross extrathyroidal invasion, distant metastases, radioiodine (RAI) resistance, and avidity for 18-fluorodeoxyglucose (positron emission tomography-positive), is found in approximately 10-20% of patients with DTC.
iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes.
Wang et al., Tianjin, China. In Biochem Biophys Res Commun, 2012
These findings showed that iAPSS/iASPPsv reduced the growth inhibition and apoptosis induced by Dex or VP-16, with DNA damage accumulating which might promote the pathogenesis and/or progression of cancer.
iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes.
Liu et al., Chongqing, China. In Apoptosis, 2012
iASPP inhibited apoptosis independently of p53 in tumor cells, mainly by inhibiting the transcriptional activity of p63/p73 on the promoters of proapoptotic genes
Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP.
Wang et al., Dalian, China. In Oncol Rep, 2012
Downregulation of iASPP by siRNA stimulated apoptosis through p53 in two non-small cell lung cancer cell lines
A specific diplotype defined by PPP1R13L rs1970764, CD3EAP rs967591 and ERCC1 rs11615 and lung cancer risk in a Chinese population.
Li et al., Shenyang, China. In Lung Cancer, 2012
variant alleles of PPP1R13L rs1970764 and CD3EAP rs967591 may contribute to risk factors of lung cancer.
Hapmap-based evaluation of ERCC2, PPP1R13L, and ERCC1 and lung cancer risk in a Chinese population.
Sun et al., Shenyang, China. In Environ Mol Mutagen, 2012
Highly significant differential distributions of haplotypes defined by both nine haplotype-tagging SNPs covering ERCC2 and PPP1R13L and fourteen haplotype-tagging SNPs covering ERCC2, PPP1R13L, and ERCC1 were found.
MDM2 SNP309 is associated with poor outcome in B-cell chronic lymphocytic leukemia.
Tinhofer et al., Salzburg, Austria. In J Clin Oncol, 2008
The influence of the heterozygous SNP309 T/G genotype on treatment-free survival depended on the p53 status but not on the CD38, Zap-70, or IgVH mutational status or Rai stage of B-CLL patients.
Abdominal computed tomography predicts progression in patients with Rai stage 0 chronic lymphocytic leukemia.
Montserrat et al., Barcelona, Spain. In J Clin Oncol, 2007
The aim of this study was to analyze the prognostic significance of abdominal CT in patients with CLL in Rai clinical stage 0. PATIENTS AND METHODS: Abdominal CT was performed at diagnosis in 140 patients consecutively diagnosed with CLL in Rai stage 0 disease.
Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia.
Dewald et al., Rochester, United States. In J Clin Oncol, 2006
PATIENTS AND METHODS: Between 1994 and 2002, we enrolled 159 patients with previously untreated CLL (83% Rai stage 0/I) on a prospective trial evaluating clonal evolution by FISH.
Richter's syndrome: a report on 39 patients.
Keating et al., Houston, United States. In J Clin Oncol, 1993
Patients at all Rai stages and in complete response (CR) were at risk, including three CR patients with no residual disease at the level of detection by dual-parameter flow cytometry or restriction analysis for immunoglobulin (Ig) gene rearrangements.
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