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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Oct 2014.

Protein phosphatase 1, regulatory subunit 13 like

Rai
IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, CD38, ZAP-70
Papers on Rai
Serum copper is a simple but valuable prognostic marker in B-cell chronic lymphocytic leukemia.
New
Etewa et al., Az Zaqāzīq, Egypt. In Int J Hematol, 08 Nov 2014
No significant difference was found with regard to Rai staging for CLL.
Decreased dickkopf-1 levels in chronic lymphocytic leukemia and increased osteopontin levels in non-Hodgkin's lymphoma at initial diagnosis: Could they be playing roles in pathogenesis?
New
Tapan et al., In Hematology, 01 Nov 2014
CLL patients with early and late Rai stages of disease had similar DKK-1 and OPN levels.
New Meets Old: A Case Study and Review of Novel Therapeutics for the Treatment of CLL in Older Patients.
New
Andreadis et al., San Francisco, United States. In J Natl Compr Canc Netw, 31 Oct 2014
This case report presents a 75-year-old man with Rai stage II CLL complicated by massive splenomegaly, high-risk cytogenetics, and intolerance to first-line therapy recommended by the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Non-Hodgkin's Lymphomas.
Clinical and Molecular Features of Hürthle Cell Carcinoma of the Thyroid.
New
Smallridge et al., Jacksonville, United States. In J Clin Endocrinol Metab, 26 Oct 2014
RAI scan performs poorly in detecting distant disease.
The evolving field of kinase inhibitors in thyroid cancer.
Review
New
Faggiano et al., Napoli, Italy. In Crit Rev Oncol Hematol, 16 Oct 2014
The role of KIs in differentiated TC may be revolutionised by the finding that selumetinib may restore a clinical response to radioactive iodine (RAI).
Accelerated disease progression after discontinuation of sorafenib in a patient with metastatic papillary thyroid cancer.
New
Cha et al., Seoul, South Korea. In Endocrinol Metab (seoul), 30 Sep 2014
A 43-year-old male was diagnosed with PTC in February 2004 and underwent total thyroidectomy followed by two courses of high-dose radioactive iodine (RAI) therapy.
The current role of targeted therapies to induce radioiodine uptake in thyroid cancer.
Review
New
Wahl et al., Tübingen, Germany. In Cancer Treat Rev, Jun 2014
Although the mode of action is not clear, the combination of tyrosine kinase inhibitors and RAI treatment could improve clinical responses in non-radioiodine avid metastatic thyroid carcinoma.
Regional arterial infusion with lipoxin a4 attenuates experimental severe acute pancreatitis.
New
Zhou et al., Wenzhou, China. In Plos One, Dec 2013
OBJECTIVE: Investigate the therapeutic effect of regional arterial infusion (RAI) with Aspirin-Triggered Lipoxin A4 (ATL) in experimental severe acute pancreatitis (SAP) in rats.
Evolving approaches to patients with advanced differentiated thyroid cancer.
Review
New
Impact
Sherman et al., Aurora, United States. In Endocr Rev, Jun 2013
Advanced differentiated thyroid cancer (DTC), defined by clinical characteristics including gross extrathyroidal invasion, distant metastases, radioiodine (RAI) resistance, and avidity for 18-fluorodeoxyglucose (positron emission tomography-positive), is found in approximately 10-20% of patients with DTC.
New developments in thyroid cancer.
Review
New
Haddad, Boston, United States. In J Natl Compr Canc Netw, May 2013
Unfortunately, when the disease becomes refractory to radioactive iodine (RAI), few effective treatment options remain.
Overview of recent developments in chronic lymphocytic leukemia.
Review
Rai et al., United States. In South Asian J Cancer, 2012
These advances in CLL have come a long way in the past three decades since the development of Rai and Binet clinical staging systems.
iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes.
GeneRIF
Wang et al., Tianjin, China. In Biochem Biophys Res Commun, 2012
These findings showed that iAPSS/iASPPsv reduced the growth inhibition and apoptosis induced by Dex or VP-16, with DNA damage accumulating which might promote the pathogenesis and/or progression of cancer.
iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes.
GeneRIF
Liu et al., Chongqing, China. In Apoptosis, 2012
iASPP inhibited apoptosis independently of p53 in tumor cells, mainly by inhibiting the transcriptional activity of p63/p73 on the promoters of proapoptotic genes
Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP.
GeneRIF
Wang et al., Dalian, China. In Oncol Rep, 2012
Downregulation of iASPP by siRNA stimulated apoptosis through p53 in two non-small cell lung cancer cell lines
A specific diplotype defined by PPP1R13L rs1970764, CD3EAP rs967591 and ERCC1 rs11615 and lung cancer risk in a Chinese population.
GeneRIF
Li et al., Shenyang, China. In Lung Cancer, 2012
variant alleles of PPP1R13L rs1970764 and CD3EAP rs967591 may contribute to risk factors of lung cancer.
Hapmap-based evaluation of ERCC2, PPP1R13L, and ERCC1 and lung cancer risk in a Chinese population.
GeneRIF
Sun et al., Shenyang, China. In Environ Mol Mutagen, 2012
Highly significant differential distributions of haplotypes defined by both nine haplotype-tagging SNPs covering ERCC2 and PPP1R13L and fourteen haplotype-tagging SNPs covering ERCC2, PPP1R13L, and ERCC1 were found.
MDM2 SNP309 is associated with poor outcome in B-cell chronic lymphocytic leukemia.
Impact
Tinhofer et al., Salzburg, Austria. In J Clin Oncol, 2008
The influence of the heterozygous SNP309 T/G genotype on treatment-free survival depended on the p53 status but not on the CD38, Zap-70, or IgVH mutational status or Rai stage of B-CLL patients.
Abdominal computed tomography predicts progression in patients with Rai stage 0 chronic lymphocytic leukemia.
Impact
Montserrat et al., Barcelona, Spain. In J Clin Oncol, 2007
The aim of this study was to analyze the prognostic significance of abdominal CT in patients with CLL in Rai clinical stage 0. PATIENTS AND METHODS: Abdominal CT was performed at diagnosis in 140 patients consecutively diagnosed with CLL in Rai stage 0 disease.
Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia.
Impact
Dewald et al., Rochester, United States. In J Clin Oncol, 2006
PATIENTS AND METHODS: Between 1994 and 2002, we enrolled 159 patients with previously untreated CLL (83% Rai stage 0/I) on a prospective trial evaluating clonal evolution by FISH.
Richter's syndrome: a report on 39 patients.
Impact
Keating et al., Houston, United States. In J Clin Oncol, 1993
Patients at all Rai stages and in complete response (CR) were at risk, including three CR patients with no residual disease at the level of detection by dual-parameter flow cytometry or restriction analysis for immunoglobulin (Ig) gene rearrangements.
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