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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 Apr 2016.

Protein phosphatase 1, regulatory subunit 13 like

Rai
IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, CD38, ZAP-70
Papers on Rai
Robust Thyroid Gene Expression and Radioiodine Uptake Induced by Simultaneous Suppression of BRAF V600E and Histone Deacetylase in Thyroid Cancer Cells.
New
Xing et al., Baltimore, United States. In J Clin Endocrinol Metab, Feb 2016
UNASSIGNED: Context Use of BRAF V600E inhibitors to restore thyroid iodide-handing gene expression and radioactive iodine (RAI) avidity is an attractive therapeutic strategy for RAI-refractory thyroid cancer, but recent initial clinical responses were modest.
Lenvatinib: Role in thyroid cancer and other solid tumors.
Review
New
Habra et al., Houston, United States. In Cancer Treat Rev, Jan 2016
Lenvatinib is approved for treatment of locally recurrent or metastatic, progressive, radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC).
Impaired immune regulation after radioiodine therapy for Graves' disease and the protective effect of Methimazole.
New
Rottembourg et al., Sherbrooke, Canada. In Endocrine, Jan 2016
UNASSIGNED: Both therapies for Graves' disease (GD), radioactive iodine (RAI) and antithyroid drugs (ATD), were reported to have specific immune effects.
Comparison of Antagonist Muscle Activity During Walking Between Total Knee Replacement and Control Subjects Using Unnormalized Electromyography.
New
Wimmer et al., Chicago, United States. In J Arthroplasty, Jan 2016
We developed a relative activation index (RAI) to compare leg muscle activity from unnormalized surface electromyography (sEMG) between TKR and control subjects.
Selective inhibitors of aurora kinases inhibit proliferation, reduce cell viability and impair cell cycle progression in papillary thyroid carcinoma cells.
New
Ulisse et al., Roma, Italy. In J Biol Regul Homeost Agents, Oct 2015
In the present study, we sought to establish whether Aurora kinase inhibition could be of any therapeutic value in the treatment of aggressive forms of PTC, enduring to radioactive iodide (RAI) ablation.
The discovery and development of sorafenib for the treatment of thyroid cancer.
Review
New
Cohen et al., Ann Arbor, United States. In Expert Opin Drug Discov, Apr 2015
INTRODUCTION: Although the prognosis for most differentiated thyroid cancers (DTCs) remains excellent, recurrence and insensitivity to radioactive iodine (RAI) lead to therapeutic challenges and poorer outcomes.
Sorafenib: a review of its use in patients with radioactive iodine-refractory, metastatic differentiated thyroid carcinoma.
Review
New
Plosker et al., Auckland, New Zealand. In Target Oncol, Mar 2015
Sorafenib (Nexavar®) is the first tyrosine kinase inhibitor to be approved for the treatment of radioactive iodine (RAI)-refractory differentiated thyroid carcinoma (DTC).
Differentiated thyroid cancer: focus on emerging treatments for radioactive iodine-refractory patients.
Review
New
Colevas et al., Stanford, United States. In Oncologist, Feb 2015
BACKGROUND: The treatment of differentiated thyroid cancer refractory to radioactive iodine (RAI) had been hampered by few effective therapies.
New therapies for dedifferentiated papillary thyroid cancer.
Review
Antonelli et al., Pisa, Italy. In Int J Mol Sci, 2014
Standard treatment usually includes primary surgery, thyroid-stimulating hormone suppressive therapy, and ablation of the thyroid remnant with radioactive iodine (RAI).
Association between sodium iodide symporter and differentiated Thyroid cancer: a meta-analysis of 9 studies.
Dong et al., Jinan, China. In Int J Clin Exp Med, 2014
CONTEXT: As many studies proved that sodium iodide symporter (NIS) plays a key role in radioactive iodide (RAI) therapy of thyroid cancer, however, a growing number of studies suggests that part of differentiated thyroid carcinomas (DTC) with overexpression of NIS are insensitive to RAI well.
Evolving approaches to patients with advanced differentiated thyroid cancer.
Review
Impact
Sherman et al., Aurora, United States. In Endocr Rev, 2013
Advanced differentiated thyroid cancer (DTC), defined by clinical characteristics including gross extrathyroidal invasion, distant metastases, radioiodine (RAI) resistance, and avidity for 18-fluorodeoxyglucose (positron emission tomography-positive), is found in approximately 10-20% of patients with DTC.
iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes.
GeneRIF
Wang et al., Tianjin, China. In Biochem Biophys Res Commun, 2012
These findings showed that iAPSS/iASPPsv reduced the growth inhibition and apoptosis induced by Dex or VP-16, with DNA damage accumulating which might promote the pathogenesis and/or progression of cancer.
iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes.
GeneRIF
Liu et al., Chongqing, China. In Apoptosis, 2012
iASPP inhibited apoptosis independently of p53 in tumor cells, mainly by inhibiting the transcriptional activity of p63/p73 on the promoters of proapoptotic genes
Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP.
GeneRIF
Wang et al., Dalian, China. In Oncol Rep, 2012
Downregulation of iASPP by siRNA stimulated apoptosis through p53 in two non-small cell lung cancer cell lines
A specific diplotype defined by PPP1R13L rs1970764, CD3EAP rs967591 and ERCC1 rs11615 and lung cancer risk in a Chinese population.
GeneRIF
Li et al., Shenyang, China. In Lung Cancer, 2012
variant alleles of PPP1R13L rs1970764 and CD3EAP rs967591 may contribute to risk factors of lung cancer.
Hapmap-based evaluation of ERCC2, PPP1R13L, and ERCC1 and lung cancer risk in a Chinese population.
GeneRIF
Sun et al., Shenyang, China. In Environ Mol Mutagen, 2012
Highly significant differential distributions of haplotypes defined by both nine haplotype-tagging SNPs covering ERCC2 and PPP1R13L and fourteen haplotype-tagging SNPs covering ERCC2, PPP1R13L, and ERCC1 were found.
MDM2 SNP309 is associated with poor outcome in B-cell chronic lymphocytic leukemia.
Impact
Tinhofer et al., Salzburg, Austria. In J Clin Oncol, 2008
The influence of the heterozygous SNP309 T/G genotype on treatment-free survival depended on the p53 status but not on the CD38, Zap-70, or IgVH mutational status or Rai stage of B-CLL patients.
Abdominal computed tomography predicts progression in patients with Rai stage 0 chronic lymphocytic leukemia.
Impact
Montserrat et al., Barcelona, Spain. In J Clin Oncol, 2007
The aim of this study was to analyze the prognostic significance of abdominal CT in patients with CLL in Rai clinical stage 0. PATIENTS AND METHODS: Abdominal CT was performed at diagnosis in 140 patients consecutively diagnosed with CLL in Rai stage 0 disease.
Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia.
Impact
Dewald et al., Rochester, United States. In J Clin Oncol, 2006
PATIENTS AND METHODS: Between 1994 and 2002, we enrolled 159 patients with previously untreated CLL (83% Rai stage 0/I) on a prospective trial evaluating clonal evolution by FISH.
Richter's syndrome: a report on 39 patients.
Impact
Keating et al., Houston, United States. In J Clin Oncol, 1993
Patients at all Rai stages and in complete response (CR) were at risk, including three CR patients with no residual disease at the level of detection by dual-parameter flow cytometry or restriction analysis for immunoglobulin (Ig) gene rearrangements.
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