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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 11 Dec 2014.

Protein phosphatase 1, regulatory subunit 13 like

Rai
IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, CD38, ZAP-70
Papers on Rai
IL-6, IL-10, c-Jun and STAT3 expression in B-CLL.
New
Baszak et al., Lublin, Poland. In Blood Cells Mol Dis, 25 Dec 2014
When analyzing the relationship between c-Jun expression and B-CLL stage according Rai we revealed decreasing c-Jun expression, both at the mRNA and protein levels, along with advancing stage of disease.
Sorafenib treatment of radioiodine-refractory advanced thyroid cancer in daily clinical practice: a cohort study from a single center.
New
Arvat et al., Torino, Italy. In Endocrine, 21 Dec 2014
UNLABELLED: Treatment options for recurrent or metastatic differentiated thyroid cancer (DTC) refractory to radioactive iodine (RAI) are inadequate.
Treatment strategies for radioactive iodine-refractory differentiated thyroid cancer.
Review
New
Worden, Ann Arbor, United States. In Ther Adv Med Oncol, 30 Nov 2014
Until recently, no truly effective treatment options have existed for patients with radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC), a serious disease with poor prognosis.
Dissociable Roles of Right Inferior Frontal Cortex and Anterior Insula in Inhibitory Control: Evidence from Intrinsic and Task-Related Functional Parcellation, Connectivity, and Response Profile Analyses across Multiple Datasets.
New
Menon et al., Stanford, United States. In J Neurosci, 29 Nov 2014
The right inferior frontal cortex (rIFC) and the right anterior insula (rAI) have been implicated consistently in inhibitory control, but their differential roles are poorly understood.
Do Biologic Parameters Affect the Time to First Treatment of Clinical Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia Rai Stage 0? Results of a Prospective Analysis.
New
Morabito et al., Catanzaro, Italy. In Clin Lymphoma Myeloma Leuk, Oct 2014
BACKGROUND: We investigated the clinical relevance of classic and new prognostic markers, immunoglobulin heavy-chain variable (IGHV) gene mutational status, and chromosomal abnormalities in clinical monoclonal B lymphocytosis (cMBL) compared with chronic lymphocytic leukemia (CLL) Rai stage 0.
The evolving field of kinase inhibitors in thyroid cancer.
Review
New
Faggiano et al., Napoli, Italy. In Crit Rev Oncol Hematol, Oct 2014
The role of KIs in differentiated TC may be revolutionised by the finding that selumetinib may restore a clinical response to radioactive iodine (RAI).
The current role of targeted therapies to induce radioiodine uptake in thyroid cancer.
Review
New
Wahl et al., Tübingen, Germany. In Cancer Treat Rev, Jun 2014
Although the mode of action is not clear, the combination of tyrosine kinase inhibitors and RAI treatment could improve clinical responses in non-radioiodine avid metastatic thyroid carcinoma.
Symptom dimensions are associated with reward processing in unmedicated persons at risk for psychosis.
New
Kaiser et al., Zürich, Switzerland. In Front Behav Neurosci, Dec 2013
Positive symptoms were correlated with the anticipation signal in the ventral striatum (VS) and the right anterior insula (rAI).
Evolving approaches to patients with advanced differentiated thyroid cancer.
Review
New
Impact
Sherman et al., Aurora, United States. In Endocr Rev, Jun 2013
Advanced differentiated thyroid cancer (DTC), defined by clinical characteristics including gross extrathyroidal invasion, distant metastases, radioiodine (RAI) resistance, and avidity for 18-fluorodeoxyglucose (positron emission tomography-positive), is found in approximately 10-20% of patients with DTC.
New developments in thyroid cancer.
Review
New
Haddad, Boston, United States. In J Natl Compr Canc Netw, May 2013
Unfortunately, when the disease becomes refractory to radioactive iodine (RAI), few effective treatment options remain.
Overview of recent developments in chronic lymphocytic leukemia.
Review
Rai et al., United States. In South Asian J Cancer, 2012
These advances in CLL have come a long way in the past three decades since the development of Rai and Binet clinical staging systems.
iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes.
GeneRIF
Wang et al., Tianjin, China. In Biochem Biophys Res Commun, 2012
These findings showed that iAPSS/iASPPsv reduced the growth inhibition and apoptosis induced by Dex or VP-16, with DNA damage accumulating which might promote the pathogenesis and/or progression of cancer.
iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes.
GeneRIF
Liu et al., Chongqing, China. In Apoptosis, 2012
iASPP inhibited apoptosis independently of p53 in tumor cells, mainly by inhibiting the transcriptional activity of p63/p73 on the promoters of proapoptotic genes
Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP.
GeneRIF
Wang et al., Dalian, China. In Oncol Rep, 2012
Downregulation of iASPP by siRNA stimulated apoptosis through p53 in two non-small cell lung cancer cell lines
A specific diplotype defined by PPP1R13L rs1970764, CD3EAP rs967591 and ERCC1 rs11615 and lung cancer risk in a Chinese population.
GeneRIF
Li et al., Shenyang, China. In Lung Cancer, 2012
variant alleles of PPP1R13L rs1970764 and CD3EAP rs967591 may contribute to risk factors of lung cancer.
Hapmap-based evaluation of ERCC2, PPP1R13L, and ERCC1 and lung cancer risk in a Chinese population.
GeneRIF
Sun et al., Shenyang, China. In Environ Mol Mutagen, 2012
Highly significant differential distributions of haplotypes defined by both nine haplotype-tagging SNPs covering ERCC2 and PPP1R13L and fourteen haplotype-tagging SNPs covering ERCC2, PPP1R13L, and ERCC1 were found.
MDM2 SNP309 is associated with poor outcome in B-cell chronic lymphocytic leukemia.
Impact
Tinhofer et al., Salzburg, Austria. In J Clin Oncol, 2008
The influence of the heterozygous SNP309 T/G genotype on treatment-free survival depended on the p53 status but not on the CD38, Zap-70, or IgVH mutational status or Rai stage of B-CLL patients.
Abdominal computed tomography predicts progression in patients with Rai stage 0 chronic lymphocytic leukemia.
Impact
Montserrat et al., Barcelona, Spain. In J Clin Oncol, 2007
The aim of this study was to analyze the prognostic significance of abdominal CT in patients with CLL in Rai clinical stage 0. PATIENTS AND METHODS: Abdominal CT was performed at diagnosis in 140 patients consecutively diagnosed with CLL in Rai stage 0 disease.
Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia.
Impact
Dewald et al., Rochester, United States. In J Clin Oncol, 2006
PATIENTS AND METHODS: Between 1994 and 2002, we enrolled 159 patients with previously untreated CLL (83% Rai stage 0/I) on a prospective trial evaluating clonal evolution by FISH.
Richter's syndrome: a report on 39 patients.
Impact
Keating et al., Houston, United States. In J Clin Oncol, 1993
Patients at all Rai stages and in complete response (CR) were at risk, including three CR patients with no residual disease at the level of detection by dual-parameter flow cytometry or restriction analysis for immunoglobulin (Ig) gene rearrangements.
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