GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Protein phosphatase 1, regulatory subunit 13 like
Rai
IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008] (from
NCBI)
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Papers on
Rai
VEGF and bFGF gene polymorphisms in Polish patients with B-CLL.
New
Wrocław, Poland. In Med Oncol, 31 Mar 2013
The VEGF alleles and genotypes segregated similarly in patients with different stage of the disease according to Rai classification.
Renin-Angiotensin-Aldosterone System and Hypothalamic-Pituitary-Adrenal Axis in Hospitalized Newborn Foals.
New
Columbus, United States. In J Vet Intern Med, 11 Mar 2013
HPAA dysfunction and relative adrenal insufficiency (RAI) are common in septic foals.
The Shc family protein adaptor, Rai, acts as a negative regulator of Th17 and Th1 cell development.
New
Siena, Italy. In J Leukoc Biol, 23 Feb 2013
Rai, a Shc adapter family member, acts as a negative regulator of antigen receptor signaling in T and B cells.
Clinical, Safety, and Economic Evidence in Radioactive Iodine-Refractory Differentiated Thyroid Cancer: A Systematic Literature Review.
New
Penn Hills, United States. In Thyroid, 07 Feb 2013
While most cases of DTC are curable with the use of surgery and radioactive iodine (RAI) ablation of the remaining thyroid remnant, prognosis is dire and treatment options limited when DTC becomes RAI-refractory (RAI-R).
Extraesophageal Reflux: What Is the Best Parameter for pH-Monitoring Data Analysis from the Perspective of Patient Response to Proton Pump Inhibitors?
New
Ostrava, Czech Republic. In Gastroenterol Res Pract, Dec 2012
To analyze the pH-monitoring records of patients with suspected extraesophageal reflux (EER) using three different parameters (number of refluxes (NOR), acid exposure time (AET), and reflux area index (RAI)), with a view to determining which type of analysis is best at selecting the patients who will respond to a proton pump inhibitor (PPI).
Treating the thyroid in the presence of Graves' ophthalmopathy.
Review
New
Odense, Denmark. In Best Pract Res Clin Endocrinol Metab, Jun 2012
Whether antithyroid drugs (ATDs), radioiodine (RAI), or thyroidectomy should be favored in such patients remains debated.
Radioactive iodine (131I) therapy for differentiated thyroid cancer in Japan: current issues with historical review and future perspective.
Review
New
Moriyama, Japan. In Ann Nucl Med, Feb 2012
Radioactive iodine (RAI, (131)I) has been used as a therapeutic agent for differentiated thyroid cancer (DTC) with over 50 years of history.
Genetic variations in multiple myeloma II: association with effect of treatment.
Review
New
Roskilde, Denmark. In Eur J Haematol, Feb 2012
Candidate genes for prediction of effect of HDT include DNA repair genes, CYP genes and genes involved in inflammation and apoptosis such as IL1B and RAI.
Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia.
Review
Tampa, United States. In Cancer Control, 2012
The Rai and Binet clinical staging systems are used to define disease extent and predict survival.
New molecular targeted therapy and redifferentiation therapy for radioiodine-refractory advanced papillary thyroid carcinoma: literature review.
Hong Kong, Hong Kong. In J Thyroid Res, 2011
Given that patients with RAI-refractory disease tend to do significantly worse than those with radioiodine-avid or non-progressive disease, an increasing number of phase I and II studies have been conducted to evaluate the efficacy of new molecular targeted drugs such as the tyrosine kinase inhibitors and redifferentiation drugs.
iASPP and chemoresistance in ovarian cancers: effects on paclitaxel-mediated mitotic catastrophe.
GeneRIF
Hong Kong, Hong Kong. In Clin Cancer Res, 2011
Data show an association of iASPP overexpression with gene amplification in ovarian cancer and suggest a role of iASPP in poor patient outcome and chemoresistance, through blocking mitotic catastrophe.
iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia.
GeneRIF
London, United Kingdom. In Embo J, 2011
These data showed iASPP to be a key regulator of epithelial homeostasis in skin.
Adrenocortical (dys)function in septic shock - a sick euadrenal state.
Review
Brisbane, Australia. In Best Pract Res Clin Endocrinol Metab, 2011
These changes have been described by the terms "Relative Adrenal Insufficiency" (RAI), or "Critical Illness Related Corticosteroid Insufficiency" (CIRCI), and form part of the rationale for trials of glucocorticoid treatment in septic shock.
Inhibitory member of the apoptosis-stimulating protein of p53 (ASPP) family promotes growth and tumorigenesis in human p53-deficient prostate cancer cells.
GeneRIF
Guangzhou, China. In Prostate Cancer Prostatic Dis, 2011
iASPP is essential for prostate cancer cellular proliferation and survival and may be a potential target for the gene therapy for prostate cancer
Down-regulation of iASPP in human hepatocellular carcinoma cells inhibits cell proliferation and tumor growth.
GeneRIF
Guangzhou, China. In Neoplasma, 2010
results showed that iASPP mRNA and protein levels were significantly down-regulated in both cells infected with the siRNA against iASPP
iASPP is over-expressed in human non-small cell lung cancer and regulates the proliferation of lung cancer cells through a p53 associated pathway.
GeneRIF
Beijing, China. In Bmc Cancer, 2009
iASPP regulates the proliferation and motility of lung cancer cells. This effect is intimately associated with the p53 pathway.
MDM2 SNP309 is associated with poor outcome in B-cell chronic lymphocytic leukemia.
Impact
Salzburg, Austria. In J Clin Oncol, 2008
The influence of the heterozygous SNP309 T/G genotype on treatment-free survival depended on the p53 status but not on the CD38, Zap-70, or IgVH mutational status or Rai stage of B-CLL patients.
Abdominal computed tomography predicts progression in patients with Rai stage 0 chronic lymphocytic leukemia.
Impact
Barcelona, Spain. In J Clin Oncol, 2007
The aim of this study was to analyze the prognostic significance of abdominal CT in patients with CLL in Rai clinical stage 0. METHODS: Abdominal CT was performed at diagnosis in 140 patients consecutively diagnosed with CLL in Rai stage 0 disease.
Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia.
Impact
Rochester, United States. In J Clin Oncol, 2006
METHODS: Between 1994 and 2002, we enrolled 159 patients with previously untreated CLL (83% Rai stage 0/I) on a prospective trial evaluating clonal evolution by FISH.
Richter's syndrome: a report on 39 patients.
Impact
Houston, United States. In J Clin Oncol, 1993
Patients at all Rai stages and in complete response (CR) were at risk, including three CR patients with no residual disease at the level of detection by dual-parameter flow cytometry or restriction analysis for immunoglobulin (Ig) gene rearrangements.
