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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Protein phosphatase 1, regulatory subunit 13 like

Rai
IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, CD38, ZAP-70
Papers on Rai
The Role of Right Prefrontal and Medial Cortex in Response Inhibition: Interfering with Action Restraint and Action Cancellation Using Transcranial Magnetic Brain Stimulation.
New
Schuhmann et al., Maastricht, Netherlands. In J Cogn Neurosci, 24 Mar 2014
Significant task-related activation during successful action restraint was localized for each participant individually in right anterior insula (rAI), right superior frontal gyrus, and pre-SMA.
Chemotherapy induced augmentation of T cells expressing inhibitory receptors is reversed by treatment with lenalidomide in chronic lymphocytic leukemia.
New
Geisberger et al., Salzburg, Austria. In Haematologica, 21 Mar 2014
We observed that T cells expressing inhibitory receptors were increased within the CD4+ and CD8+ T cell subsets and that this increase was associated with advanced RAI stage within the CD8+ subset.
Ivabradine therapy to unmask heart rate-independent effects of β-blockers on pulse wave reflections.
New
Spyridopoulos et al., Bad Nauheim, Germany. In Clin Res Cardiol, 18 Mar 2014
We determined radial augmentation index (rAI) by radial applanation tonometry in patients under β-blockade both at rest and during early recovery after exercise.
The current role of targeted therapies to induce radioiodine uptake in thyroid cancer.
Review
New
Wahl et al., Tübingen, Germany. In Cancer Treat Rev, 21 Feb 2014
Although the mode of action is not clear, the combination of tyrosine kinase inhibitors and RAI treatment could improve clinical responses in non-radioiodine avid metastatic thyroid carcinoma.
Sorafenib in metastatic radioactive iodine-refractory differentiated thyroid cancer: A pilot study.
New
He et al., Beijing, China. In Mol Clin Oncol, Jan 2014
UNLABELLED: The incidence and mortality of thyroid cancer are on the increase worldwide and the treatment options for progressive, radioactive iodine (RAI)-refractory metastatic differentiated thyroid cancer (DTC) patients are currently limited.
Hand-foot syndrome associated with use of sorafenib in a patient with papillary thyroid cancer: a case report.
New
Gómez-Abreo et al., Floridablanca, Colombia. In Bmc Endocr Disord, Dec 2013
CONCLUSION: Sorafenib as a new therapeutic option for patients with radioactive iodine (RAI)-resistant metastatic differentiated thyroid cancer, it is important that clinicians are fully aware of the potential adverse effects.
Evolving approaches to patients with advanced differentiated thyroid cancer.
Review
New
Impact
Sherman et al., Aurora, United States. In Endocr Rev, Jun 2013
Advanced differentiated thyroid cancer (DTC), defined by clinical characteristics including gross extrathyroidal invasion, distant metastases, radioiodine (RAI) resistance, and avidity for 18-fluorodeoxyglucose (positron emission tomography-positive), is found in approximately 10-20% of patients with DTC.
New developments in thyroid cancer.
Review
New
Haddad, Boston, United States. In J Natl Compr Canc Netw, May 2013
Unfortunately, when the disease becomes refractory to radioactive iodine (RAI), few effective treatment options remain.
Clinical, safety, and economic evidence in radioactive iodine-refractory differentiated thyroid cancer: a systematic literature review.
Review
New
Wirth et al., State College, United States. In Thyroid, Apr 2013
While most cases of DTC are curable with the use of surgery and radioactive iodine (RAI) ablation of the remaining thyroid remnant, prognosis is dire and treatment options limited when DTC becomes RAI-refractory (RAI-R).
Multivariable model consisting of clinical and biological markers for time to first treatment in CLL patients: Preliminary results from single centre experience.
Panovska-Stavridis et al., Скопје, Macedonia. In Prilozi, 2012
We then combined the following independent characteristics: age, β-2 microglobulin, absolute lymphocyte count, sex, Rai stage, and number of involved lymph node groups, which are included in some of the already published CLL prognostics index, in association with the CD38 expression and mutational status of the immunoglobulin heavy chain gene variable region (IGVH).
Overview of recent developments in chronic lymphocytic leukemia.
Review
Rai et al., United States. In South Asian J Cancer, 2012
These advances in CLL have come a long way in the past three decades since the development of Rai and Binet clinical staging systems.
iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes.
GeneRIF
Wang et al., Tianjin, China. In Biochem Biophys Res Commun, 2012
These findings showed that iAPSS/iASPPsv reduced the growth inhibition and apoptosis induced by Dex or VP-16, with DNA damage accumulating which might promote the pathogenesis and/or progression of cancer.
iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes.
GeneRIF
Liu et al., Chongqing, China. In Apoptosis, 2012
iASPP inhibited apoptosis independently of p53 in tumor cells, mainly by inhibiting the transcriptional activity of p63/p73 on the promoters of proapoptotic genes
Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP.
GeneRIF
Wang et al., Dalian, China. In Oncol Rep, 2012
Downregulation of iASPP by siRNA stimulated apoptosis through p53 in two non-small cell lung cancer cell lines
A specific diplotype defined by PPP1R13L rs1970764, CD3EAP rs967591 and ERCC1 rs11615 and lung cancer risk in a Chinese population.
GeneRIF
Li et al., Shenyang, China. In Lung Cancer, 2012
variant alleles of PPP1R13L rs1970764 and CD3EAP rs967591 may contribute to risk factors of lung cancer.
Hapmap-based evaluation of ERCC2, PPP1R13L, and ERCC1 and lung cancer risk in a Chinese population.
GeneRIF
Sun et al., Shenyang, China. In Environ Mol Mutagen, 2012
Highly significant differential distributions of haplotypes defined by both nine haplotype-tagging SNPs covering ERCC2 and PPP1R13L and fourteen haplotype-tagging SNPs covering ERCC2, PPP1R13L, and ERCC1 were found.
MDM2 SNP309 is associated with poor outcome in B-cell chronic lymphocytic leukemia.
Impact
Tinhofer et al., Salzburg, Austria. In J Clin Oncol, 2008
The influence of the heterozygous SNP309 T/G genotype on treatment-free survival depended on the p53 status but not on the CD38, Zap-70, or IgVH mutational status or Rai stage of B-CLL patients.
Abdominal computed tomography predicts progression in patients with Rai stage 0 chronic lymphocytic leukemia.
Impact
Montserrat et al., Barcelona, Spain. In J Clin Oncol, 2007
The aim of this study was to analyze the prognostic significance of abdominal CT in patients with CLL in Rai clinical stage 0. PATIENTS AND METHODS: Abdominal CT was performed at diagnosis in 140 patients consecutively diagnosed with CLL in Rai stage 0 disease.
Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia.
Impact
Dewald et al., Rochester, United States. In J Clin Oncol, 2006
PATIENTS AND METHODS: Between 1994 and 2002, we enrolled 159 patients with previously untreated CLL (83% Rai stage 0/I) on a prospective trial evaluating clonal evolution by FISH.
Richter's syndrome: a report on 39 patients.
Impact
Keating et al., Houston, United States. In J Clin Oncol, 1993
Patients at all Rai stages and in complete response (CR) were at risk, including three CR patients with no residual disease at the level of detection by dual-parameter flow cytometry or restriction analysis for immunoglobulin (Ig) gene rearrangements.
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