Perforin Promotes Amyloid Beta Internalisation in Neurons.
Huddinge, Sweden. In Mol Neurobiol, Feb 2016
We here investigated how extracellular Aβ peptides are internalised and focused on three different pathways: (i) via endocytic mechanisms, (ii) via the receptor for advanced glycation end products (RAGE) and (iii) via the pore-forming protein perforin.
Role of chitinase-like proteins in cancer.
In Biol Chem, Feb 2016
In experimental models YKL-40 supports tumor initiation through binding to RAGE, and is able to induce cancer cell proliferation via ERK1/2-MAPK pathway.
Dendritic cells decide CD8(+) T cell fate.
Glasgow, United Kingdom. In Immunity, 2014
(2014) propose that CD103(+) DCs in mouse lung selectively generate effector CD8(+) T cells by binding the alarmin HMGB1 via CD24 and presenting it to RAGE(+) T cells.
HMGB1 and RAGE in inflammation and cancer.
Gaithersburg, United States. In Annu Rev Immunol, 2009
HMGB1 can associate with other molecules, including TLR ligands and cytokines, and activates cells through the differential engagement of multiple surface receptors including TLR2, TLR4, and RAGE.