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RAE1 RNA export 1 homolog

Rae1, GLE2, Gle2p
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NKG2D, ACID, CAN, MHC, CD8
Papers on Rae1
Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy.
New
van Deursen et al., In J Clin Invest, Feb 2016
We determined that NUP88 and the nuclear transport factors NUP98 and RAE1 comprise a regulatory network that inhibits premitotic activity of the anaphase-promoting complex/cyclosome (APC/C).
Increased Bacterial Load and Expression of Antimicrobial Peptides in Skin of Barrier-Deficient Mice with Reduced Cancer Susceptibility.
New
Watt et al., Cambridge, United Kingdom. In J Invest Dermatol, Jan 2016
The tumor-protective mechanism involves signaling between Rae-1 expressing keratinocytes and the natural killer group 2D receptor on immune cells, which also plays a role in host defenses against infection.
Sex difference of autosomal alleles in populations of European and African descent.
New
Luo et al., New Haven, United States. In Journal 2093-4947, Jan 2016
We found 13 markers that were genome-wide significant (p≤5×10(-8)) between females and males in the meta-analysis of all cohorts of European descent, including rs7740449 at SYNE1, rs7531151 at PLD5, rs697455 at PPP1R12B, rs6745746 at LOC100128413, rs17000079 at PARM1, rs11948070 at PDE4D, rs7801825 at INSIG1, rs9551642 at MTUS2, rs2932174 at TPTE2, rs1961597 at SALL3, rs4117529 at METTL4, rs6021473 at SALL4 and rs6092466 at RAE1, and one marker, i.e., rs10145208 at PCNX, that was genome-wide significant in the meta-analysis of all cohorts of African descent.
Increased Bacterial Load and Expression of Antimicrobial Peptides in Skin of Barrier-Deficient Mice with Reduced Cancer Susceptibility.
New
Watt et al., Sapporo, Japan. In J Invest Dermatol, Oct 2015
The tumour-protective mechanism involves signalling between Rae-1 expressing keratinocytes and the Natural Killer Group 2D (NKG2D) receptor on immune cells, which also plays a role in host defences against infection.
Accumulation and activation of epidermal γδ T cells in a mouse model of chronic dermatitis is not required for the inflammatory phenotype.
New
Werner et al., Zürich, Switzerland. In Eur J Immunol, Sep 2015
Their number and activation further increase as the phenotype progresses, most likely as a consequence of increased expression of Il-2 and Il-7 and the stress-induced proteins Rae-1, H60c, Mult1, PlexinB2, and Skint1.
Convergent Loss of Awn in Two Cultivated Rice Species Oryza sativa and Oryza glaberrima Is Caused by Mutations in Different Loci.
Ashikari et al., Nagoya, Japan. In G3 (bethesda), 2014
Phenotypic analyses of these libraries revealed the existence of three genes, Regulator of Awn Elongation 1 (RAE1), RAE2, and RAE3, involved in the loss of long awns in cultivated rice.
RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans.
GeneRIF
Garner et al., Minneapolis, United States. In J Neurosci, 2012
This study established a novel postmitotic function for rae-1 in neuronal development.
RAE1ε ligand expressed on pancreatic islets recruits NKG2D receptor-expressing cytotoxic T cells independent of T cell receptor recognition.
Impact
Shaw et al., Saint Louis, United States. In Immunity, 2012
With a transgenic mouse expressing the NKG2D ligand retinoic acid early transcript 1ε (RAE1ε) in β-islet cells of the pancreas, we found that RAE1 expression was sufficient to induce the recruitment of adoptively transferred CTLs to islets.
Natural killer cells recognize friend retrovirus-infected erythroid progenitor cells through NKG2D-RAE-1 interactions In Vivo.
GeneRIF
Miyazawa et al., Ōsaka, Japan. In J Virol, 2011
Expression of RAE-1 proteins on erythroblast surfaces increased early after Friend virus inoculation and infected erythroid cells are recognized by natural killer cells mainly through the NKG2D-RAE-1 interactions in vivo.
RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis.
GeneRIF
Wong et al., Kanazawa, Japan. In Cell Cycle, 2011
RAE1 transgene orchestrates proper chromosome segregation and NUP98-mediated leukemogenesis.
Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1.
GeneRIF
Lanier et al., San Francisco, United States. In J Immunol, 2010
In a transgenic mouse model of chronic natural killer NKG2D ligand expression, constant exposure to NKG2D ligand RNA export 1 homolog (Rae-1 epsilon) does not functionally impair NK cells or CD8-positive T cells in the context of viral infection.
Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1.
GeneRIF
Hoelz et al., New York City, United States. In Proc Natl Acad Sci U S A, 2010
present the crystal structure of human Rae1 in complex with the Gle2-binding sequence (GLEBS) of Nup98 at 1.65 A resolution. Rae1 forms a seven-bladed beta-propeller with several extensive surface loops.
Murine NKG2D ligands: "double, double toil and trouble".
Review
Malarkannan et al., Milwaukee, United States. In Mol Immunol, 2009
They include ULBP (1-3), MIC (A & B) in human and H60 (a, b & c), Rae-1 (alpha-epsilon) and Mult1 in mice.
Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis.
Impact
Girardi et al., London, United Kingdom. In Nat Immunol, 2008
The self-encoded ligands MICA (human) and Rae-1 (mouse) for the cytotoxic lymphocyte activating receptor NKG2D are highly expressed in carcinomas and inflammatory lesions and have been linked to immunosurveillance and graft rejection.
Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance.
Impact
Hayday et al., London, United Kingdom. In Nat Immunol, 2005
Upregulation of the inducible gene products MICA (human) and Rae-1 (mouse) may promote tumor surveillance and autoimmunity by engaging the activating receptor NKG2D on natural killer (NK) cells and T cells.
NKG2D blockade prevents autoimmune diabetes in NOD mice.
Impact
Lanier et al., San Francisco, United States. In Immunity, 2004
Here we show that RAE-1 is present in prediabetic pancreas islets of NOD mice and that autoreactive CD8(+) T cells infiltrating the pancreas express NKG2D.
Structure of the Ly49 family of natural killer (NK) cell receptors and their interaction with MHC class I molecules.
Review
Biassoni et al., Genova, Italy. In Immunol Res, 2003
These signals are mediated by NK cell receptors that bind either classical MHC class I molecules or their structural relatives such as MICA, ULBP, RAE-1, and H-60.
Asymmetric ligand recognition by the activating natural killer cell receptor NKG2D, a symmetric homodimer.
Review
Strong, Seattle, United States. In Mol Immunol, 2002
NKG2D ligands in rodents include the MHC class I-like proteins RAE-1 and H60 and, in humans, ULBPs and the cell stress-inducible proteins MICA and MICB.
MHC class I recognition by Ly49 natural killer cell receptors.
Review
Mariuzza et al., Bethesda, United States. In Mol Immunol, 2002
Natural killer (NK) cell function is regulated by NK receptors that bind either classical MHC class I (MHC-I) molecules or their structural relatives (MICA, RAE-1 and H-60).
Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination.
Review
Impact
Margulies et al., Bethesda, United States. In Annu Rev Immunol, 2001
In contrast to T cell receptors, signal transducing cell surface membrane molecules involved in the regulation of responses by cells of the innate immune system employ structures that are encoded in the genome rather than generated by somatic recombination and that recognize either classical MHC-I molecules or their structural relatives (such as MICA, RAE-1, or H-60).
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