DNA Damage Response Genes and the Development of Cancer Metastasis.
New York City, United States. In Radiat Res, 07 Feb 2014
Several genes that participate in the DNA damage response, such as RAD9, PARP1, BRCA1, ATM and TP53 have been associated with metastasis by a number of in vitro biochemical and cellular assays, by examining human tumor specimens by immunohistochemistry or by DNA genome-wide gene expression profiling.
The role of RAD9 in tumorigenesis.
New York City, United States. In J Mol Cell Biol, 2011
Interestingly, human RAD9 overproduction correlates with prostate cancer whereas deletion of Mrad9, the corresponding mouse gene, in keratinocytes leads to skin cancer.
ATM signaling and 53BP1.
United States. In Radiother Oncol, 2005
One of the proteins that sense these chromatin structure changes is 53BP1, a DNA damage checkpoint protein conserved in all eukaryotes and the putative ortholog of the S. cerevisiae RAD9 protein.
G2 checkpoint abrogators as anticancer drugs.
Numazu, Japan. In Mol Cancer Ther, 2004
Damaged DNA in humans is detected by sensor proteins (such as hHUS1, hRAD1, hRAD9, hRAD17, and hRAD26) that transmit a signal via ATR to CHK1, or by another sensor complex (that may include gammaH2AX, 53BP1, BRCA1, NBS1, hMRE11, and hRAD50), the signal of which is relayed by ATM to CHK2.
Analysis of the effect of radiation repair mutations on the DEL1 mutator region of Saccharomyces cerevisiae.
Chicago, United States. In Curr Genet, 1983
To this end, we independently coupled eight repair mutations, rad3-2, rad4-4, rad6-1, rad6-3, rad9-1, rev3-1, rad50-1, and rad51-1, toDEL1 and asked whether DEL1 was still functional.