DNA damage response genes and the development of cancer metastasis.
New York City, United States. In Radiat Res, Feb 2014
Several genes that participate in the DNA damage response, such as RAD9, PARP1, BRCA1, ATM and TP53 have been associated with metastasis by a number of in vitro biochemical and cellular assays, by examining human tumor specimens by immunohistochemistry or by DNA genome-wide gene expression profiling.
Contributions of Rad9 to tumorigenesis.
New York City, United States. In J Cell Biochem, 2012
A review of the many activities assigned to Rad9, and speculation as to which influence its function in tumor development.
Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance.
San Diego, United States. In Biomolecules, 2011
Since the original discovery of RAD9, the first DNA damage checkpoint gene identified in Saccharomyces cerevisiae, many genes that have a role in this pathway have been identified, including MRC1, MEC3, RAD24, RAD53, DUN1, MEC1 and TEL1.
9-1-1: PCNA's specialized cousin.
Oxford, United Kingdom. In Trends Biochem Sci, 2011
The RAD9 is loaded to damaged sites where it serves as a platform for the selective recruitment of checkpoint and repair proteins.
The role of RAD9 in tumorigenesis.
New York City, United States. In J Mol Cell Biol, 2011
Interestingly, human RAD9 overproduction correlates with prostate cancer whereas deletion of Mrad9, the corresponding mouse gene, in keratinocytes leads to skin cancer.
ATM signaling and 53BP1.
United States. In Radiother Oncol, 2005
One of the proteins that sense these chromatin structure changes is 53BP1, a DNA damage checkpoint protein conserved in all eukaryotes and the putative ortholog of the S. cerevisiae RAD9 protein.
G2 checkpoint abrogators as anticancer drugs.
Numazu, Japan. In Mol Cancer Ther, 2004
Damaged DNA in humans is detected by sensor proteins (such as hHUS1, hRAD1, hRAD9, hRAD17, and hRAD26) that transmit a signal via ATR to CHK1, or by another sensor complex (that may include gammaH2AX, 53BP1, BRCA1, NBS1, hMRE11, and hRAD50), the signal of which is relayed by ATM to CHK2.