Invasive oral cancer stem cells display resistance to ionising radiation.
London, United Kingdom. In Oncotarget, Jan 2016
We propose that this is a result of preferential activation of the DNA damagerepair pathway in oral CSC with increased activation of ATM and BRCA1, elevated levels of DNA repair proteins RAD52, XLF, and a significantly faster rate of DNA double-strand-breaks clearance 24 hours following IR.
There and back again: new single-molecule insights in the motion of DNA repair proteins.
Iowa City, United States. In Curr Opin Struct Biol, 2013
This review will address new insights into diffusive properties of three DNA repair systems: I will discuss the emerging model of how MutS homologues locate and respond to mismatches in the dsDNA; the mechanism by which RAD52 promotes annealing of complementary DNA strands coated with ssDNA binding protein RPA; and how the nucleoprotein filament formed by RecA recombinase on ssDNA searches for homology within duplex DNA.
More forks on the road to replication stress recovery.
Fort Collins, United States. In J Mol Cell Biol, 2011
Additional complexity in the replication stress response centers around RPA, which undergoes significant post-translational modification after stress, and RAD52, a conserved HR protein whose role in DSB repair may have shifted to another protein in higher eukaryotes, such as BRCA2, but retained its role in fork restart.
Proteomic changes during the B cell development.
South Korea. In J Chromatogr B Analyt Technol Biomed Life Sci, 2005
RAD52-related protein and chromatin assembly factor 1 are dominantly expressed at early B cells undergoing DNA rearrangement.
Recombination proteins in yeast.
New York City, United States. In Annu Rev Genet, 2003
Central to the process of homologous recombination are the RAD52 group genes (RAD50, RAD51, RAD52, RAD54, RDH54/TID1, RAD55, RAD57, RAD59, MRE11, and XRS2), most of which were identified by their requirement for the repair of ionizing radiation-induced DNA damage in Saccharomyces cerevisiae.
Homologous recombinational repair proteins in mouse meiosis.
Bar Harbor, United States. In Cytogenet Genome Res, 2003
In this review, we discuss primarily those proteins involved in the initial stages of homologous recombination, including SPO11, MRE11, RAD50, NBS1, DMC1, RAD51, RAD51 paralogs, RAD52, RPA, RAD54, and RAD54B.