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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

RAD52 Rad52p

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rad51, CAN, RAD54, Rad50, rad1
Papers on RAD52
Double-strand break repair and colorectal cancer: gene variants within 3' UTRs and microRNAs binding as modulators of cancer risk and clinical outcome.
Pardini et al., Torino, Italy. In Oncotarget, Jan 2016
In colon cancer patients, the rs2155209 CC genotype was associated with shorter survival while the TT genotype of RAD52 rs11226 with longer survival when both compared with their respective more frequent genotypes (HR 1.63, 95% CI 1.06-2.51,
Invasive oral cancer stem cells display resistance to ionising radiation.
Mackenzie et al., London, United Kingdom. In Oncotarget, Jan 2016
We propose that this is a result of preferential activation of the DNA damagerepair pathway in oral CSC with increased activation of ATM and BRCA1, elevated levels of DNA repair proteins RAD52, XLF, and a significantly faster rate of DNA double-strand-breaks clearance 24 hours following IR.
Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection.
Skorski et al., Gainesville, United States. In Plos One, Dec 2015
It has been reported that inhibition of RAD52 either by specific shRNA or a small peptide aptamer induced synthetic lethality in tumor cell lines carrying BRCA1 and BRCA2 inactivating mutations.
Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers.
Pomerantz et al., Philadelphia, United States. In Chem Biol, Dec 2015
Suppression of RAD52 causes synthetic lethality in BRCA-deficient cells.
Members of the RAD52 Epistasis Group Contribute to Mitochondrial Homologous Recombination and Double-Strand Break Repair in Saccharomyces cerevisiae.
Sia et al., Rochester, United States. In Plos Genet, Nov 2015
This study investigated the contribution of the nuclear double-strand break repair (DSBR) proteins Rad51p, Rad52p and Rad59p in mtDNA repair.
Identification of an SCLC susceptibility rs7963551 genetic polymorphism in a previously GWAS-identified 12p13.33 RAD52 lung cancer risk locus in the Chinese population.
Yang et al., Beijing, China. In Int J Clin Exp Med, 2014
As a well-known DNA repair gene, RAD52 plays an essential role in homologous recombination repair of double strand break, maintenance of genomic stability and prevention of cell malignant transformation.
There and back again: new single-molecule insights in the motion of DNA repair proteins.
Spies, Iowa City, United States. In Curr Opin Struct Biol, 2013
This review will address new insights into diffusive properties of three DNA repair systems: I will discuss the emerging model of how MutS homologues locate and respond to mismatches in the dsDNA; the mechanism by which RAD52 promotes annealing of complementary DNA strands coated with ssDNA binding protein RPA; and how the nucleoprotein filament formed by RecA recombinase on ssDNA searches for homology within duplex DNA.
Role of Rad52 in fractionated irradiation induced signaling in A549 lung adenocarcinoma cells.
Krishna et al., Mumbai, India. In Mutat Res, 2012
Silencing of the Rad52 gene in fractionated group of A549 cells made the cells radiosensitive.
Mgm101 is a Rad52-related protein required for mitochondrial DNA recombination.
Chen et al., Syracuse, United States. In J Biol Chem, 2012
Mgm101 is a Rad52-related protein required for mitochondrial DNA recombination
Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding.
Spies et al., Urbana, United States. In Embo J, 2011
RAD52(Y104pCMF) specifically targets and wraps ssDNA. Phosphorylation at Y104 enhances ssDNA annealing activity of RAD52 by attenuating dsDNA binding.
Minisatellite alterations in ZRT1 mutants occur via RAD52-dependent and RAD52-independent mechanisms in quiescent stationary phase yeast cells.
Kirkpatrick et al., Minneapolis, United States. In Dna Repair (amst), 2011
revealed that minisatellite alterations in a Deltazrt1 mutant occur by a combination of RAD52-dependent and RAD52-independent mechanisms
A genetic and structural study of genome rearrangements mediated by high copy repeat Ty1 elements.
Kolodner et al., San Diego, United States. In Plos Genet, 2011
Ty1 sequence-specific gross chromosomal rearrangements are RAD52-dependent.
More forks on the road to replication stress recovery.
Nickoloff et al., Fort Collins, United States. In J Mol Cell Biol, 2011
Additional complexity in the replication stress response centers around RPA, which undergoes significant post-translational modification after stress, and RAD52, a conserved HR protein whose role in DSB repair may have shifted to another protein in higher eukaryotes, such as BRCA2, but retained its role in fork restart.
Telomeres avoid end detection by severing the checkpoint signal transduction pathway.
Ferreira et al., Portugal. In Nature, 2010
2), recruit DNA repair proteins (Rad22(RAD52) and Rhp51(RAD51), where the superscript indicates the human orthologue) and checkpoint sensors (RPA, Rad9, Rad26(ATRIP) and Cut5/Rad4(TOPBP1)) to telomeres.
A two-step model for senescence triggered by a single critically short telomere.
Teixeira et al., Lyon, France. In Nat Cell Biol, 2009
Data suggest that in the absence of telomerase, a very short telomere is first maintained in a pre-signalling state by a RAD52-MMS1-dependent pathway and then switches to a signalling state leading to senescence through a Mec1p-dependent checkpoint.
SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions.
Aragón et al., London, United Kingdom. In Nat Cell Biol, 2005
Furthermore, deletion of RAD52 partially suppresses the temperature sensitivity of smc5-6 and smc6-9 mutants.
Proteomic changes during the B cell development.
Kim, South Korea. In J Chromatogr B Analyt Technol Biomed Life Sci, 2005
RAD52-related protein and chromatin assembly factor 1 are dominantly expressed at early B cells undergoing DNA rearrangement.
INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.
Shen et al., United States. In Cell, 2005
Finally, components of the INO80 complex show synthetic genetic interactions with the RAD52 DNA repair pathway, the main pathway for DSB repair in yeast.
Recombination proteins in yeast.
Symington et al., New York City, United States. In Annu Rev Genet, 2003
Central to the process of homologous recombination are the RAD52 group genes (RAD50, RAD51, RAD52, RAD54, RDH54/TID1, RAD55, RAD57, RAD59, MRE11, and XRS2), most of which were identified by their requirement for the repair of ionizing radiation-induced DNA damage in Saccharomyces cerevisiae.
Homologous recombinational repair proteins in mouse meiosis.
Schimenti et al., Bar Harbor, United States. In Cytogenet Genome Res, 2003
In this review, we discuss primarily those proteins involved in the initial stages of homologous recombination, including SPO11, MRE11, RAD50, NBS1, DMC1, RAD51, RAD51 paralogs, RAD52, RPA, RAD54, and RAD54B.
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