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RAD51 homolog C

This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rad51, XRCC3, RAD51B, poly(A)-binding protein, Iris
Papers on RAD51C
Rad51C: a novel suppressor gene modulates the risk of head and neck cancer.
Wasowicz et al., Łódź, Poland. In Mutat Res Fundam Mol Mech Mutagen, Apr 2014
We conducted a case-control study to investigate the possible association between the head and neck cancer (HNC) and genetic variability of Rad51C tumor suppressor gene.
Next-generation sequencing for the diagnosis of hereditary breast and ovarian cancer using genomic capture targeting multiple candidate genes.
Vaur et al., Caen, France. In Eur J Hum Genet, Mar 2014
We also found 36 variations inducing either a premature codon stop or a splicing defect among other genes: 5/708 in CHEK2, 3/708 in RAD51C, 1/708 in RAD50, 7/708 in PALB2, 3/708 in MRE11A, 5/708 in ATM, 3/708 in NBS1, 1/708 in CDH1, 3/468 in MSH2, 2/468 in PMS2, 1/708 in BARD1, 1/468 in PMS1 and 1/468 in MLH3.
Clinical characteristics of ovarian cancer classified by BRCA1, BRCA2, and RAD51C status.
Goode et al., Cambridge, United Kingdom. In Sci Rep, Dec 2013
We evaluated homologous recombination deficient (HRD) phenotypes in epithelial ovarian cancer (EOC) considering BRCA1, BRCA2, and RAD51C in a large well-annotated patient set.
Aberrant DNA methylation status of DNA repair genes in breast cancer treated with neoadjuvant chemotherapy.
Ohta et al., Kawasaki, Japan. In Genes Cells, Dec 2013
The aberrant DNA methylation status of the following HR related-genes was analyzed using bisulfite-pyrosequencing: BRCA1, BRCA2, BARD1, MDC1, RNF8, RNF168, UBC13, ABRA1, PALB2, RAD50, RAD51, RAD51C, MRE11, NBS1, CtIP and ATM.
Meta-analysis identifies four new loci associated with testicular germ cell tumor.
Nathanson et al., Bethesda, United States. In Nat Genet, Jun 2013
P = 4.04 × 10(-9)), a locus that includes TEX14, RAD51C and PPM1E.
RAD51C deletion screening identifies a recurrent gross deletion in breast cancer and ovarian cancer families.
Hahnen et al., In Breast Cancer Res, 2012
RAD51C is an integral part of the DNA double-strand repair through homologous recombination, and monoallelic mutations were found in ~1.3% of BRCA1/2-negative breast cancer (BC) and/or ovarian cancer (OC) families.
Breast cancer genes: beyond BRCA1 and BRCA2.
Vega et al., Spain. In Front Biosci, 2012
Moreover, a combination of family-based and population-based approaches indicated that genes involved in DNA repair, such as CHEK2, ATM, BRIP1 (FANCJ), PALB2 (FANCN) and RAD51C (FANCO), are associated with moderate BC risk.
Hereditary genes and SNPs associated with breast cancer.
Nasiri et al., Mashhad, Iran. In Asian Pac J Cancer Prev, 2012
The most important loci which include mutations are; BRCA1, BRCA2, PTEN, ATM, TP53, CHEK2, PPM1D, CDH1, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PMS1, PMS2, BRIP1, RAD50, RAD51C, STK11 and BARD1.
High sensitivity for BRCA1/2 mutations in breast/ovarian kindreds: are there still other breast/ovary genes to be discovered?
Evans et al., In Breast Cancer Res Treat, 2012
the contribution of RAD51C and RAD51D gene mutations to an inherited high risk of ovarian cancer is very small
Genetic testing by cancer site: ovary.
Newlin et al., Evanston, United States. In Cancer J, 2012
In addition, newly discovered genes (eg, RAD51C and RAD51D) linked to ovarian cancer are discussed.
Evaluation of RAD51C as cancer susceptibility gene in a large breast-ovarian cancer patient population referred for genetic testing.
Claes et al., Gent, Belgium. In Breast Cancer Res Treat, 2012
RAD51C germline mutations in families with a history for both breast and ovarian cancer appear to have a low prevalence with the exception of some founder mutations.
Hereditary ovarian cancer: beyond the usual suspects.
Swisher et al., Seattle, United States. In Gynecol Oncol, 2012
Recently, three new ovarian cancer susceptibility genes have been identified: RAD51C, RAD51D, and BRIP1.
Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.
Nagaraju et al., Bengaluru, India. In J Biol Chem, 2012
unravel the critical role of RAD51C in the FA pathway of ICL repair and as a tumor suppressor.
Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients.
Campbell et al., Melbourne, Australia. In Hum Mutat, 2012
Missense variant of RAD51C (p.Gly264Ser) is a moderate penetrance allele in high-risk breast and ovarian cancer families.
RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesis.
Tarsounas et al., Oxford, United Kingdom. In Semin Cell Dev Biol, 2011
In addition to RAD51, the central recombinase activity in mammalian cells, a family of proteins known as the RAD51 paralogs and consisting of five proteins (RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3), play an essential role in the DNA repair reactions through HR.
Germline mutations in RAD51D confer susceptibility to ovarian cancer.
Rahman et al., United Kingdom. In Nat Genet, 2011
Recently, RAD51C mutations were identified in families with breast and ovarian cancer.
RAD51C germline mutations in breast and ovarian cancer cases from high-risk families.
Neuhausen et al., Duarte, United States. In Plos One, 2010
RAD51C is a rare breast and ovarian cancer susceptibility gene.
Fanconi anemia and breast cancer susceptibility meet again.
Levy-Lahad, Jerusalem, Israel. In Nat Genet, 2010
A new study reports biallelic mutations in RAD51C in a Fanconi anemia-like disorder, while a second study reports monoallelic mutations in the same gene associated with increased breast cancer risk.
Mutation of the RAD51C gene in a Fanconi anemia-like disorder.
Mathew et al., London, United Kingdom. In Nat Genet, 2010
biallelic germline mutations in a RAD51 paralog are associated with an FA-like syndrome [case report]
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.
Hanenberg et al., München, Germany. In Nat Genet, 2010
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene
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