GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
RAD51 homolog C
RAD51C, RAD51L2, AtRAD51C
This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from
NCBI)
Sponsored links
Papers on
RAD51C
ATM- and ATR-mediated phosphorylation of XRCC3 regulates DNA double-strand break-induced checkpoint activation and repair.
New
Bengaluru, India. In Mol Cell Biol, 25 Mar 2013
The RAD51 paralogs XRCC3 and RAD51C have been implicated in homologous recombination (HR) and DNA damage responses.
Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.
New
New York City, United States. In Mol Cell Biol, Jan 2013
The Rad51 paralogs associate with one another in two distinct complexes: Rad51B-Rad51C-Rad51D-XRCC2 (BCDX2) and Rad51C-XRCC3 (CX3).
Genetic testing by cancer site: ovary.
Review
New
Evanston, United States. In Cancer J, Jul 2012
In addition, newly discovered genes (eg, RAD51C and RAD51D) linked to ovarian cancer are discussed.
Hereditary ovarian cancer: beyond the usual suspects.
Review
New
Seattle, United States. In Gynecol Oncol, Feb 2012
Recently, three new ovarian cancer susceptibility genes have been identified: RAD51C, RAD51D, and BRIP1.
Screening of Finnish RAD51C founder mutations in prostate and colorectal cancer patients.
Helsinki, Finland. In Bmc Cancer, 2011
BACKGROUND: Rare, heterozygous germline mutations in the RAD51C gene have been found in breast and ovarian cancer families.
RAD51 and breast cancer susceptibility: no evidence for rare variant association in the Breast Cancer Family Registry study.
Lyon, France. In Plos One, 2011
RAD51 plays a central biological function in DNA repair and despite the fact that rare, likely dysfunctional variants in three of its five paralogs, RAD51C, RAD51D, and XRCC2, have been associated with breast and/or ovarian cancer risk, no population-based case-control mutation screening data are available for the RAD51 gene.
Analysis of 30 putative BRCA1 splicing mutations in hereditary breast and ovarian cancer families identifies exonic splice site mutations that escape in silico prediction.
Köln, Germany. In Plos One, 2011
Screening for pathogenic mutations in breast and ovarian cancer genes such as BRCA1/2, CHEK2 and RAD51C is common practice for individuals from high-risk families.
RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesis.
Review
Oxford, United Kingdom. In Semin Cell Dev Biol, 2011
In addition to RAD51, the central recombinase activity in mammalian cells, a family of proteins known as the RAD51 paralogs and consisting of five proteins (RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3), play an essential role in the DNA repair reactions through HR.
Germline mutations in RAD51D confer susceptibility to ovarian cancer.
Impact
United Kingdom. In Nat Genet, 2011
Recently, RAD51C mutations were identified in families with breast and ovarian cancer.
RAD51C is a susceptibility gene for ovarian cancer.
GeneRIF
Helsinki, Finland. In Hum Mol Genet, 2011
These results suggest RAD51C as the first moderate-to-high risk susceptibility gene for ovarian cancer.
FANCP/SLX4: a Swiss army knife of DNA interstrand crosslink repair.
Review
United States. In Cell Cycle, 2011
A recent spate of discoveries has led to the identification of one new FA gene, FANCP/SLX4, and two strong candidate FA genes, FAN1 and RAD51C.
BRIP1, PALB2, and RAD51C mutation analysis reveals their relative importance as genetic susceptibility factors for breast cancer.
GeneRIF
Newcastle, Australia. In Breast Cancer Res Treat, 2011
PALB2 mutations are present in a small but substantial proportion of inherited breast cancer cases, and indicates that RAD51C at a population level does not account for a substantial number of familial breast cancer cases
Hereditary breast and ovarian cancer: new genes, new treatments, new concepts.
Review
München, Germany. In Dtsch Arztebl Int, 2011
RESULTS: High risk is conferred by the highly penetrant BRCA1 and BRCA2 genes as well as by other genes such as RAD51C.
RAD51C: a novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer.
Review
GeneRIF
Bengaluru, India. In Carcinogenesis, 2010
Reports show RAD51C is a cancer susceptibility gene associated with increased risk of Fanconi anemia-like disorder, breast and ovarian cancer.[Review]
RAD51C germline mutations in breast and ovarian cancer cases from high-risk families.
GeneRIF
Duarte, United States. In Plos One, 2010
RAD51C is a rare breast and ovarian cancer susceptibility gene.
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.
Impact
GeneRIF
München, Germany. In Nat Genet, 2010
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene
Fanconi anemia and breast cancer susceptibility meet again.
Impact
Jerusalem, Israel. In Nat Genet, 2010
A new study reports biallelic mutations in RAD51C in a Fanconi anemia-like disorder, while a second study reports monoallelic mutations in the same gene associated with increased breast cancer risk.
Mutation of the RAD51C gene in a Fanconi anemia-like disorder.
Impact
GeneRIF
London, United Kingdom. In Nat Genet, 2010
biallelic germline mutations in a RAD51 paralog are associated with an FA-like syndrome [case report]
RAD51C germline mutations in breast and ovarian cancer patients.
GeneRIF
In Breast Cancer Res, 2009
Data show there was no deleterious RAD51C mutation among the 454 familial breast/ovarian cancer patients.
RAD18 transmits DNA damage signalling to elicit homologous recombination repair.
Impact
New Haven, United States. In Nat Cell Biol, 2009
We further demonstrate that RAD18 functions as an adaptor to facilitate homologous recombination through direct interaction with the recombinase RAD51C.
