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RAD51 homolog C

RAD51C, RAD51L2, AtRAD51C
This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rad51, XRCC3, poly(A)-binding protein, RAD51B, Iris
Papers on RAD51C
Genetic Testing for RAD51C Mutations: In the Clinic and in the Community.
New
Narod et al., Toronto, Canada. In Clin Genet, 03 Jan 2015
Germline mutations in RAD51C have been identified in about 1% of hereditary breast and ovarian cancer families.
Inherited Mutations in 17 Breast Cancer Susceptibility Genes Among a Large Triple-Negative Breast Cancer Cohort Unselected for Family History of Breast Cancer.
New
Impact
Fasching et al., Rochester, United States. In J Clin Oncol, 01 Jan 2015
Deleterious mutations in 15 other predisposition genes were detected in 3.7% of patients, with the majority observed in genes involved in homologous recombination, including PALB2 (1.2%) and BARD1, RAD51D, RAD51C, and BRIP1 (0.3% to 0.5%).
[Current Clinical Issues and Recent Trends in Hereditary Breast and Ovarian Cancer in Japan-Genetic Testing for HBOC and Risk-Reducing Surgery].
New
Takeshima et al., In Gan To Kagaku Ryoho, 30 Nov 2014
Recently, candidate genes other than BRCA1/2, such as RAD51C, PALB2, and BRIP1, have been identified for hereditary breast cancers.
Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase (PARP).
New
Nagaraju et al., Bengaluru, India. In Carcinogenesis, 07 Nov 2014
The RAD51 paralog RAD51C has been identified as a breast and ovarian cancer susceptibility gene.
PALB2: the hub of a network of tumor suppressors involved in DNA damage responses.
Review
New
Andreassen et al., Cincinnati, United States. In Biochim Biophys Acta, Aug 2014
More recently, PALB2 has been found to bind the RAD51 paralog, RAD51C, as well as the translesion polymerase pol η, both of which are tumor suppressors with functions in HR.
Single Nucleotide Polymorphisms in Noncoding Regions of Rad51C Do Not Change the Risk of Unselected Breast Cancer but They Modulate the Level of Oxidative Stress and the DNA Damage Characteristics: A Case-Control Study.
New
Wasowicz et al., Łódź, Poland. In Plos One, Dec 2013
Deleterious and missense mutations of RAD51C have recently been suggested to modulate the individual susceptibility to hereditary breast and ovarian cancer and unselected ovarian cancer, but not unselected breast cancer (BrC).
gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair.
New
Boidot et al., Le François, Martinique. In J Vis Exp, Dec 2013
This protocol was developed to safely study 11 genes (ATM, BARD1, BRCA1, BRCA2, BRIP1, CHEK2, PALB2, RAD50, RAD51C, RAD80, and TP53) from promoter to 3'-UTR in 24 patients simultaneously.
Meta-analysis identifies four new loci associated with testicular germ cell tumor.
New
Impact
Nathanson et al., Bethesda, United States. In Nat Genet, Jun 2013
P = 4.04 × 10(-9)), a locus that includes TEX14, RAD51C and PPM1E.
Hereditary genes and SNPs associated with breast cancer.
Review
Nasiri et al., Mashhad, Iran. In Asian Pac J Cancer Prev, 2012
The most important loci which include mutations are; BRCA1, BRCA2, PTEN, ATM, TP53, CHEK2, PPM1D, CDH1, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PMS1, PMS2, BRIP1, RAD50, RAD51C, STK11 and BARD1.
Breast cancer genes: beyond BRCA1 and BRCA2.
Review
Vega et al., Spain. In Front Biosci, 2012
Moreover, a combination of family-based and population-based approaches indicated that genes involved in DNA repair, such as CHEK2, ATM, BRIP1 (FANCJ), PALB2 (FANCN) and RAD51C (FANCO), are associated with moderate BC risk.
High sensitivity for BRCA1/2 mutations in breast/ovarian kindreds: are there still other breast/ovary genes to be discovered?
GeneRIF
Evans et al., In Breast Cancer Res Treat, 2012
the contribution of RAD51C and RAD51D gene mutations to an inherited high risk of ovarian cancer is very small
Genetic testing by cancer site: ovary.
Review
Newlin et al., Evanston, United States. In Cancer J, 2012
In addition, newly discovered genes (eg, RAD51C and RAD51D) linked to ovarian cancer are discussed.
Evaluation of RAD51C as cancer susceptibility gene in a large breast-ovarian cancer patient population referred for genetic testing.
GeneRIF
Claes et al., Gent, Belgium. In Breast Cancer Res Treat, 2012
RAD51C germline mutations in families with a history for both breast and ovarian cancer appear to have a low prevalence with the exception of some founder mutations.
Hereditary ovarian cancer: beyond the usual suspects.
Review
Swisher et al., Seattle, United States. In Gynecol Oncol, 2012
Recently, three new ovarian cancer susceptibility genes have been identified: RAD51C, RAD51D, and BRIP1.
Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.
GeneRIF
Nagaraju et al., Bengaluru, India. In J Biol Chem, 2012
unravel the critical role of RAD51C in the FA pathway of ICL repair and as a tumor suppressor.
Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients.
GeneRIF
Campbell et al., Melbourne, Australia. In Hum Mutat, 2012
Missense variant of RAD51C (p.Gly264Ser) is a moderate penetrance allele in high-risk breast and ovarian cancer families.
Germline mutations in RAD51D confer susceptibility to ovarian cancer.
Impact
Rahman et al., United Kingdom. In Nat Genet, 2011
Recently, RAD51C mutations were identified in families with breast and ovarian cancer.
RAD51C germline mutations in breast and ovarian cancer cases from high-risk families.
GeneRIF
Neuhausen et al., Duarte, United States. In Plos One, 2010
RAD51C is a rare breast and ovarian cancer susceptibility gene.
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.
Impact
GeneRIF
Hanenberg et al., München, Germany. In Nat Genet, 2010
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene
Fanconi anemia and breast cancer susceptibility meet again.
Impact
Levy-Lahad, Jerusalem, Israel. In Nat Genet, 2010
A new study reports biallelic mutations in RAD51C in a Fanconi anemia-like disorder, while a second study reports monoallelic mutations in the same gene associated with increased breast cancer risk.
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