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RAD51 homolog C

RAD51C, RAD51L2, AtRAD51C
This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rad51, XRCC3, poly(A)-binding protein, RAD51B, Iris
Papers on RAD51C
Identification of six pathogenic RAD51C mutations via mutational screening of 1228 Danish individuals with increased risk of hereditary breast and/or ovarian cancer.
New
Hansen et al., Copenhagen, Denmark. In Breast Cancer Res Treat, 06 Feb 2016
UNASSIGNED: Germ-line mutations in the RAD51C gene have recently been identified in families with breast and ovarian cancer and have been associated with an increased risk of ovarian cancer.
Screening for germline mutations in breast/ovarian cancer susceptibility genes in high-risk families in Israel.
New
Friedman et al., Jerusalem, Israel. In Breast Cancer Res Treat, 31 Jan 2016
Overall, 30 cases (10.6 %) were found to carry a pathogenic actionable mutation in the tested genes: 10 BRCA1 (3 non-founder mutations), 9 BRCA2 (8 non-founder mutations), and one each in the RAD51C and CHEK2 genes.
Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families.
New
Chenevix-Trench et al., Brisbane, Australia. In J Med Genet, 31 Jan 2016
RESULTS: We found 31 putative deleterious mutations in 7 known breast cancer susceptibility genes (TP53, PALB2, ATM, CHEK2, CDH1, PTEN and STK11) in 45 cases, and 22 potential deleterious mutations in 31 cases in 8 other genes (BARD1, BRIP1, MRE11, NBN, RAD50, RAD51C, RAD51D and CDK4).
Inherited Mutations in Women With Ovarian Carcinoma.
New
Birrer et al., Providence, United States. In Jama Oncol, 30 Jan 2016
Mutations in BRIP1 (n = 26), RAD51C (n = 11), RAD51D (n = 11), PALB2 (n = 12), and BARD1 (n = 4) were significantly more common in patients with OC than in the ESP or ExAC, present in 3.3%.
Genetic characterization of early onset ovarian carcinoma.
New
Swisher et al., Seattle, United States. In Gynecol Oncol, 21 Jan 2016
We evaluated 11 genes associated with ovarian carcinoma (BARD1, BRCA1, BRCA2, BRIP1, MLH1, MSH2, MSH6, PALB2, PMS2, RAD51D, and RAD51C) and additional candidate genes in DNA repair (ATM, BAP1, CHEK2, MRE11A, NBN, PTEN, TP53).
Trans-dichlorooxovandium (IV) complex as a novel photoinducible DNA interstrand cross-linker for cancer therapy.
New
Nagaraju et al., Athens, United States. In Carcinogenesis, 17 Jan 2016
Moreover, VDC specifically targets cells that express pathological RAD51C mutants.
RAD51C mutation screening in high-risk patients from Serbian hereditary breast/ovarian cancer families.
New
Brankovic-Magic et al., Belgrade, Serbia. In Cancer Biomark, 24 Dec 2015
BACKGROUND: In 2010 an important finding was published showing that heterozygous mutations in RAD51C were highly penetrant and were able to confer an increased risk for breast and ovarian cancers.
Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.
New
Impact
Pharoah et al., Manchester, United Kingdom. In J Clin Oncol, Oct 2015
PURPOSE: The aim of this study was to estimate the contribution of deleterious mutations in the RAD51B, RAD51C, and RAD51D genes to invasive epithelial ovarian cancer (EOC) in the population and in a screening trial of individuals at high risk of ovarian cancer.
Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.
New
Impact
Fasching et al., Rochester, United States. In J Clin Oncol, Mar 2015
Deleterious mutations in 15 other predisposition genes were detected in 3.7% of patients, with the majority observed in genes involved in homologous recombination, including PALB2 (1.2%) and BARD1, RAD51D, RAD51C, and BRIP1 (0.3% to 0.5%).
Clinical Application of Multigene Panels: Challenges of Next-Generation Counseling and Cancer Risk Management.
Weitzel et al., Duarte, United States. In Front Oncol, 2014
We also discuss specific challenging cases that arose during this period involving abnormalities in the genes: CDH1, TP53, PMS2, PALB2, CHEK2, NBN, and RAD51C.
Patterns and functional implications of rare germline variants across 12 cancer types.
Ding et al., Saint Louis, United States. In Nat Commun, 2014
Burden testing identifies 13 cancer genes with significant enrichment of rare truncations, some associated with specific cancers (for example, RAD51C, PALB2 and MSH6 in AML, stomach and endometrial cancers, respectively).
[Retrospective NGS Study in High-risk Hereditary Cancer Patients at Masaryk Memorial Cancer Institute].
Foretová et al., In Klin Onkol, 2014
Various pathogenic or potentially pathogenic (missense, predicted splice site, in-frame insertion/deletion) mutations were detected in ATM, BRIP1, CDH1, CHEK2, ERCC2, ERCC3, ERCC4, FANCA, MC1R, MEN1, MRE11A, MUTYH, PALB2, RAD51C, RET, SDHB, STK11.
Meta-analysis identifies four new loci associated with testicular germ cell tumor.
Impact
Nathanson et al., Bethesda, United States. In Nat Genet, 2013
P = 4.04 × 10(-9)), a locus that includes TEX14, RAD51C and PPM1E.
High sensitivity for BRCA1/2 mutations in breast/ovarian kindreds: are there still other breast/ovary genes to be discovered?
GeneRIF
Evans et al., In Breast Cancer Res Treat, 2012
the contribution of RAD51C and RAD51D gene mutations to an inherited high risk of ovarian cancer is very small
Evaluation of RAD51C as cancer susceptibility gene in a large breast-ovarian cancer patient population referred for genetic testing.
GeneRIF
Claes et al., Gent, Belgium. In Breast Cancer Res Treat, 2012
RAD51C germline mutations in families with a history for both breast and ovarian cancer appear to have a low prevalence with the exception of some founder mutations.
Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.
GeneRIF
Nagaraju et al., Bengaluru, India. In J Biol Chem, 2012
unravel the critical role of RAD51C in the FA pathway of ICL repair and as a tumor suppressor.
Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients.
GeneRIF
Campbell et al., Melbourne, Australia. In Hum Mutat, 2012
Missense variant of RAD51C (p.Gly264Ser) is a moderate penetrance allele in high-risk breast and ovarian cancer families.
Germline mutations in RAD51D confer susceptibility to ovarian cancer.
Impact
Rahman et al., United Kingdom. In Nat Genet, 2011
Recently, RAD51C mutations were identified in families with breast and ovarian cancer.
RAD51C germline mutations in breast and ovarian cancer cases from high-risk families.
GeneRIF
Neuhausen et al., Duarte, United States. In Plos One, 2010
RAD51C is a rare breast and ovarian cancer susceptibility gene.
Fanconi anemia and breast cancer susceptibility meet again.
Impact
Levy-Lahad, Jerusalem, Israel. In Nat Genet, 2010
A new study reports biallelic mutations in RAD51C in a Fanconi anemia-like disorder, while a second study reports monoallelic mutations in the same gene associated with increased breast cancer risk.
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