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RAD51 homolog B

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: Rad51, RAD51C, poly(A)-binding protein, XRCC3, CAN
Papers on RAD51B
Detection and screening of chromosomal rearrangements in uterine leiomyomas by long-distance inverse PCR.
Kauppi et al., Helsinki, Finland. In Genes Chromosomes Cancer, Mar 2016
We used this method to screen uterine leiomyomas for rearrangements at genomic locations known to be rearrangement-prone in this tumor type: upstream HMGA2 and within RAD51B.
Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers.
Aaltonen et al., Helsinki, Finland. In Proc Natl Acad Sci U S A, Feb 2016
RAD51 paralog B (RAD51B), the preferential translocation partner of HMGA2, was up-regulated in MED12 mutant lesions, suggesting a role for this gene in the genesis of leiomyomas.
A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer.
Schildkraut et al., Toronto, Canada. In Cancer Epidemiol Biomarkers Prev, Jan 2016
RESULTS: We identified three susceptibility DNA repair genes, RAD51B (P < 5.09 × 10(-6)), MSH5 (P < 5.09 × 10(-6)), and BRCA2 (P = 5.70 × 10(-6)).
Recurrent Fusions in MYB and MYBL1 Define a Common, Transcription Factor-Driven Oncogenic Pathway in Salivary Gland Adenoid Cystic Carcinoma.
Ness et al., Mexico. In Cancer Discov, Jan 2016
In addition to detecting the most common ACC translocation, t(6;9) fusing the MYB proto-oncogene to NFIB, we also detected previously unknown t(8;9) and t(8;14) translocations fusing the MYBL1 gene to the NFIB and RAD51B genes, respectively.
Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.
Pharoah et al., Manchester, United Kingdom. In J Clin Oncol, Oct 2015
PURPOSE: The aim of this study was to estimate the contribution of deleterious mutations in the RAD51B, RAD51C, and RAD51D genes to invasive epithelial ovarian cancer (EOC) in the population and in a screening trial of individuals at high risk of ovarian cancer.
Whole-genome characterization of chemoresistant ovarian cancer.
Bowtell et al., Brisbane, Australia. In Nature, Jun 2015
We show that gene breakage commonly inactivates the tumour suppressors RB1, NF1, RAD51B and PTEN in HGSC, and contributes to acquired chemotherapy resistance.
Genomic landscape of human papillomavirus-associated cancers.
Hammerman et al., Århus, Denmark. In Clin Cancer Res, Jun 2015
Recurrent integrations in RAD51B, NR4A2, and TP63, leading to aberrant forms of these proteins, are observed in both HPV-positive head and neck squamous cell carcinoma (HNSCC) and cervical carcinoma.
Integrated Genome-wide association and hypothalamus eQTL studies indicate a link between the circadian rhythm-related gene PER1 and coping behavior.
Wimmers et al., Germany. In Sci Rep, 2014
Eight genes (ASGR1, CPAMD8, CTC1, FBXO39, IL19, LOC100511790, RAD51B, UBOX5) had cis- and five (RANGRF, PER1, PDZRN3, SH2D4B, LONP2) had trans-expressionQTL.
Characterization of uterine leiomyomas by whole-genome sequencing.
Aaltonen et al., Helsinki, Finland. In N Engl J Med, 2013
The rearrangements created tissue-specific changes consistent with a role in the initiation of leiomyoma, such as translocations of the HMGA2 and RAD51B loci and aberrations at the COL4A5-COL4A6 locus, and occurred in the presence of normal TP53 alleles.
Genetic susceptibility to triple-negative breast cancer.
Couch et al., Rochester, United States. In Cancer Res, 2013
Common variation in a subset of the 72 known breast cancer susceptibility loci identified through genome-wide association studies and other large-scale genotyping efforts have also been associated with risk of TNBC (TOX3, ESR1, RAD51L1, TERT, 19p13.1,
Seven new loci associated with age-related macular degeneration.
AMD Gene Consortium et al., Regensburg, Germany. In Nat Genet, 2013
Our results include seven loci with associations reaching P < 5 × 10(-8) for the first time, near the genes COL8A1-FILIP1L, IER3-DDR1, SLC16A8, TGFBR1, RAD51B, ADAMTS9 and B3GALTL.
Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
Swerdlow et al., London, United Kingdom. In Nat Genet, 2012
A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10(-13); odds ratio (OR) = 1.57).
Genetic predisposition factors and nasopharyngeal carcinoma risk: a review of epidemiological association studies, 2000-2011: Rosetta Stone for NPC: genetics, viral infection, and other environmental factors.
Wang et al., Rockville, United States. In Semin Cancer Biol, 2012
Consistent evidence for associations were reported for a handful of genes, including immune-related HLA Class I genes, DNA repair gene RAD51L1, cell cycle control genes MDM2 and TP53, and cell adhesion/migration gene MMP2.
DNA-repair gene variants are associated with glioblastoma survival.
Melin et al., Umeå, Sweden. In Acta Oncol, 2012
Single Nucleotide Polymorphisms in RAD51L1 gene is associated with glioblastoma.
Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium.
Spurdle et al., Rockville, United States. In Hum Mol Genet, 2012
rs11249433 at 1p.11.2, and two highly correlated single-nucleotide polymorphisms rs999737 and rs10483813 (r(2)= 0.98) at 14q24.1 (RAD51L1), for up to 46 036 invasive breast cancer cases and 46 930 controls from 39 studies, were genotyped.
RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesis.
Tarsounas et al., Oxford, United Kingdom. In Semin Cell Dev Biol, 2011
In addition to RAD51, the central recombinase activity in mammalian cells, a family of proteins known as the RAD51 paralogs and consisting of five proteins (RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3), play an essential role in the DNA repair reactions through HR.
Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer families.
Chenevix-Trench et al., Brisbane, Australia. In Breast Cancer Res Treat, 2011
our results suggest that RAD51L1 is unlikely to represent a high-penetrance breast cancer susceptibility gene.
Comprehensive pathway-based association study of DNA repair gene variants and the risk of nasopharyngeal carcinoma.
Jia et al., Guangzhou, China. In Cancer Res, 2011
findings support the notion that DNA repair genes, in particular RAD51L1, play a role in nasopharyngeal carcinoma etiology and development
Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.
Bondy et al., Houston, United States. In Carcinogenesis, 2010
polymorphisms in and haplotypes of the RAD51L1 gene, which is involved in the double-strand break repair pathway, modulate gamma-radiation-induced mutagen sensitivity.
Role of recA/RAD51 family proteins in mammals.
Nishibori et al., Okayama, Japan. In Acta Med Okayama, 2005
In mammals, 7 recA-like genes have been identified: RAD51, RAD51L1/B, RAD51L2/C, RAD51L3/D, XRCC2, XRCC3, and DMC1.
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