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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

RAD51 associated protein 1

RAD51AP1, Pir51, RAD51-interacting protein
Top mentioned proteins: Rad51, CAN, V1a, fibrillin-1, Dmc1
Papers on RAD51AP1
ATR inhibition rewires cellular signaling networks induced by replication stress.
New
Beli et al., Frankfurt am Main, Germany. In Proteomics, Dec 2015
Furthermore, our data reveal the ATR-dependent phosphorylation following replication stress and discover novel putative ATR target sites on MCM6, TOPBP1, RAD51AP1 and PSMD4.
NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
New
Wiese et al., Berkeley, United States. In Nucleic Acids Res, Dec 2015
Here, we demonstrate that NUCKS1 shares extensive sequence homology with RAD51AP1 (RAD51 associated protein 1), suggesting that these two proteins are paralogs.
Tensor GSVD of patient- and platform-matched tumor and normal DNA copy-number profiles uncovers chromosome arm-wide patterns of tumor-exclusive platform-consistent alterations encoding for cell transformation and predicting ovarian cancer survival.
Alter et al., Salt Lake City, United States. In Plos One, 2014
In 6p+12p, deletion of the p21-encoding CDKN1A and p38-encoding MAPK14 and amplification of RAD51AP1 and KRAS encode for human cell transformation, and are correlated with a cell's immortality, and a patient's shorter survival time.
RAD51AP1-deficiency in vertebrate cells impairs DNA replication.
Wiese et al., Berkeley, United States. In Dna Repair (amst), 2014
RAD51-associated protein 1 (RAD51AP1) is critical for homologous recombination (HR) by interacting with and stimulating the activities of the RAD51 and DMC1 recombinases.
MEN1 is a melanoma tumor suppressor that preserves genomic integrity by stimulating transcription of genes that promote homologous recombination-directed DNA repair.
Green et al., Worcester, United States. In Mol Cell Biol, 2013
Most importantly, we show that MEN1 functions by directly stimulating the transcription of several genes, including BRCA1, RAD51, and RAD51AP1, that encode proteins involved in HR.
Mechanistic insights into RAD51-associated protein 1 (RAD51AP1) action in homologous DNA repair.
GeneRIF
Sung et al., New Haven, United States. In J Biol Chem, 2012
We have finely mapped the two DNA binding domains in RAD51AP1 and using mutant variants, reveal that both domains are indispensable for RAD51AP1 function in cells.
Identifying microRNA/mRNA dysregulations in ovarian cancer.
Bhanot et al., New Brunswick, United States. In Bmc Res Notes, 2011
For example, the expression level of RAD51AP1 was found to be strongly anti-correlated with the expression of hsa-miR-140-3p, which was significantly down-regulated in the tumour samples.
RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase DMC1 through a conserved motif.
GeneRIF
Sung et al., New Haven, United States. In J Biol Chem, 2011
RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase DMC1 through a conserved motif.
Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1).
GeneRIF
Sung et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2011
RAD51AP1 foci colocalize with a subset of DMC1 foci in spermatocytes.
Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.
GeneRIF
Sung et al., New Haven, United States. In Nat Struct Mol Biol, 2010
Although PALB2 alone stimulates D-loop formation, it has a cooperative effect with RAD51AP1, an enhancer of RAD51.
Enhanced expression of RAD51 associating protein-1 is involved in the growth of intrahepatic cholangiocarcinoma cells.
GeneRIF
Furukawa et al., Tokyo, Japan. In Clin Cancer Res, 2008
Enhanced expression of RAD51 associating protein-1 is involved in the growth of intrahepatic cholangiocarcinoma
Germline mutations in RAD51, RAD51AP1, RAD51B, RAD51C,RAD51D, RAD52 and RAD54L do not contribute to familial chronic lymphocytic leukemia.
Houlston et al., United Kingdom. In Leuk Lymphoma, 2008
These findings indicate that germline mutations in RAD51, RAD51AP1, RAD51L1, RAD51L3, RAD52 and RAD54L are unlikely to be causal of an inherited predisposition to CLL.
Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement.
GeneRIF
Schild et al., Berkeley, United States. In Mol Cell, 2007
RAD51AP1 helps maintain genomic integrity via RAD51 recombinase enhancement.
RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination.
GeneRIF
Kanaar et al., Rotterdam, Netherlands. In Mol Cell, 2007
RAD51AP1 has a selective affinity for branched-DNA structures that are obligatory intermediates during joint molecule formation.
"Promoter array" studies identify cohorts of genes directly regulated by methylation, copy number change, or transcription factor binding in human cancer cells.
Review
Mercola et al., San Diego, United States. In Ann N Y Acad Sci, 2005
The vast majority of genes that appear to be both differentially methylated and differentially regulated between prostate epithelial and cancer cell lines are novel methylation targets, including PAK6, RAD50, TLX3, PIR51, MAP2K5, INSR, FBN1, GG2-1, representing a rich new source of candidate genes to study the role of DNA methylation in prostate tumors.
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