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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

RAD51 homolog

Rad51
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] (from NCBI)
Top mentioned proteins: CAN, Iris, H2A, V1a, POLYMERASE
Papers using Rad51 antibodies
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Supplier
Oshima Robert, In PLoS ONE, 2005
... Louis, MO, USA), c-Kit and Rad51 (Santa Cruz Biotechnology), Ki67 (Lab Vision, Fremont, ...
Papers on Rad51
Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers.
New
Aaltonen et al., Helsinki, Finland. In Proc Natl Acad Sci U S A, Feb 2016
RAD51 paralog B (RAD51B), the preferential translocation partner of HMGA2, was up-regulated in MED12 mutant lesions, suggesting a role for this gene in the genesis of leiomyomas.
Multigene testing of moderate-risk genes: be mindful of the missense.
New
Tavtigian et al., Salt Lake City, United States. In J Med Genet, Feb 2016
METHODS: We evaluated rare missense substitutions identified from a mutation screen of ATM, CHEK2, MRE11A, RAD50, NBN, RAD51, RINT1, XRCC2 and BARD1 in 1297 cases of early-onset breast cancer and 1121 controls via scores from Align-Grantham Variation Grantham Deviation (GVGD), combined annotation dependent depletion (CADD), multivariate analysis of protein polymorphism (MAPP) and PolyPhen-2.
Moderate stress responses and specific changes in polyamine metabolism characterize Scots pine somatic embryogenesis.
New
Vuosku et al., Oulu, Finland. In Tree Physiol, Feb 2016
Cellular PA contents and the expression of the PA metabolism genes arginine decarboxylase (ADC), spermidine synthase (SPDS), thermospermine synthase (ACL5) and diamine oxidase (DAO) were analyzed, as well as the expression of catalase (CAT), DNA repair genes (RAD51, KU80) and autophagy-related genes (ATG5, ATG8) throughout the induction of somatic embryo formation in Scots pine SE cultures.
Adipose mesenchymal stromal cells response to ionizing radiation.
New
Muanza et al., Montréal, Canada. In Cytotherapy, Feb 2016
Irradiated aMSCs expressed higher □H2AX and significantly showed faster and more time-efficient IR-induced DNA damage response evident by up-regulated DNA-PKcs and RAD51.
Expression Levels of DNA Damage Repair Proteins Are Associated With Overall Survival in Platinum-Treated Advanced Urothelial Carcinoma.
New
Bellmunt et al., Boston, United States. In Clin Genitourin Cancer, Jan 2016
Immunohistochemical analysis of the following DNA repair proteins was performed: ERCC1, RAD51, BRCA1/2, PAR, and PARP-1.
A mechanism for the suppression of homologous recombination in G1 cells.
New
Impact
Durocher et al., Toronto, Canada. In Nature, Jan 2016
Restoration of the BRCA1-PALB2 interaction combined with the activation of DNA-end resection is sufficient to induce homologous recombination in G1, as measured by RAD51 recruitment, unscheduled DNA synthesis and a CRISPR-Cas9-based gene-targeting assay.
Recombination between the mouse Y chromosome short arm and an additional Y short arm-derived chromosomal segment attached distal to the X chromosome PAR.
Review
New
Burgoyne et al., Marseille, France. In Chromosoma, Dec 2015
UNASSIGNED: In a male mouse, meiosis markers of processed DNA double strand breaks (DSBs) such as DMC1 and RAD51 are regularly seen in the non-PAR region of the X chromosome; these disappear late in prophase prior to entry into the first meiotic metaphase.
Germline gene polymorphisms predisposing domestic mammals to carcinogenesis.
Review
New
Switonski et al., Freising, Germany. In Vet Comp Oncol, Dec 2015
This review summarizes the present understanding of germline gene polymorphisms, including BRCA1, BRCA2, MC1R, KIT, NRAS and RAD51, associated with predisposition to melanoma, mammary cancer, osteosarcoma and histiocytic sarcoma in dogs, cats, pigs and horses.
DNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of Radiosensitivity.
Review
New
von Neubeck et al., Heidelberg, Germany. In Semin Radiat Oncol, Oct 2015
Investigators are increasingly studying the subnuclear accumulation (ie, foci) of proteins in the DNA damage response (DDR), such as gamma-H2AX, 53BP1, or RAD51, as a surrogate of treatment sensitivity.
Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.
New
Impact
Pharoah et al., Manchester, United Kingdom. In J Clin Oncol, Oct 2015
PATIENTS AND METHODS: The coding sequence and splice site boundaries of the three RAD51 genes were sequenced and analyzed in germline DNA from a case-control study of 3,429 patients with invasive EOC and 2,772 controls as well as in 2,000 unaffected women who were BRCA1/BRCA2 negative from the United Kingdom Familial Ovarian Cancer Screening Study (UK_FOCSS) after quality-control analysis.
Mechanisms of Origin, Phenotypic Effects and Diagnostic Implications of Complex Chromosome Rearrangements.
Review
New
Haaf et al., Würzburg, Germany. In Mol Syndromol, Sep 2015
Therefore, the putative functions of the proteins encoded by ATM, BLM, WRN, ATR, MRE11, NBS1, and RAD51 in preventing CCRs are discussed.
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.
New
Impact
D'Andrea et al., Boston, United States. In Nature, Mar 2015
Knockdown of Polθ in HR-proficient cells upregulates HR activity and RAD51 nucleofilament assembly, while knockdown of Polθ in HR-deficient EOCs enhances cell death.
Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination.
New
Impact
Sfeir et al., New York City, United States. In Nature, Mar 2015
In addition, we found that loss of Polq in mice results in increased rates of homology-directed repair, evident by recombination of dysfunctional telomeres and accumulation of RAD51 at double-stranded breaks.
An Overview of the Molecular Mechanisms of Recombinational DNA Repair.
Review
Kowalczykowski, Davis, United States. In Cold Spring Harb Perspect Biol, 2014
The ssDNA is a scaffold for assembly of the RecA/RAD51 filament, which promotes the homology search.
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.
Impact
O'Neill et al., Oxford, United Kingdom. In Nat Cell Biol, 2014
BRCA2 has a fundamental role in error-free DNA repair but also sustains genome integrity by promoting RAD51 nucleofilament formation at stalled replication forks.
Rad51 is an accessory factor for Dmc1-mediated joint molecule formation during meiosis.
Impact
GeneRIF
Bishop et al., Chicago, United States. In Science, 2012
study provides biochemical evidence that Rad51 acts as an accessory factor with Mei5-Sae3 for Dmc1-mediated joint molecule formation during meios; Rad51 is a multifunctional protein that catalyzes recombination directly in mitosis and indirectly, via Dmc1, during meiosis
RAD51 mutants cause replication defects and chromosomal instability.
GeneRIF
Hasty et al., San Antonio, United States. In Mol Cell Biol, 2012
study found low levels of mutant RAD51 protein were sufficient for disruption of RAD51 activity and generation of chromosomal rearrangements.
Saccharomyces cerevisiae Dmc1 and Rad51 proteins preferentially function with Tid1 and Rad54 proteins, respectively, to promote DNA strand invasion during genetic recombination.
GeneRIF
Kowalczykowski et al., Davis, United States. In J Biol Chem, 2012
Rad51-Rad54 function together to promote intersister DNA strand exchange, whereas Dmc1-Tid1 tilt the bias toward interhomolog DNA strand exchange.
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.
Impact
GeneRIF
Jasin et al., New York City, United States. In Cancer Cell, 2012
show a repair-independent requirement for FA genes, including FANCD2, and BRCA1 in protecting stalled replication forks from degradation
A single nucleotide polymorphism in the 5' untranslated region of RAD51 and ovarian cancer risk in Polish women.
GeneRIF
Kokołaszwili et al., Łódź, Poland. In Eur J Gynaecol Oncol, 2011
the polymorphism 135G > C of RAD51 may be positively associated with ovarian carcinoma in the Polish population.
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