Recognition and repair of chemically heterogeneous structures at DNA ends.
United States. In Environ Mol Mutagen, 2015
Nucleolytic processing enzymes such as the MRE11/RAD50/NBS1/CtIP complex, Flap endonuclease (FEN1) and the apurinic endonucleases (APE1 and APE2) also act in the chemical "cleansing" of DNA breaks to prevent genomic instability and disease, and promote progression of DNA- and RNA-DNA damage response (DDR and RDDR) pathways.
The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once.
Berkeley, United States. In Dna Repair (amst), 2014
Here, we review protein-DNA structures for nucleases involved in replication, base excision repair, mismatch repair, double strand break repair (DSBR), and telomere maintenance: apurinic/apyrimidinic endonuclease 1 (APE1), Endonuclease IV (Nfo), tyrosyl DNA phosphodiesterase (TDP2), UV Damage endonuclease (UVDE), very short patch repair endonuclease (Vsr), Endonuclease V (Nfi), Flap endonuclease 1 (FEN1), exonuclease 1 (Exo1), RNase T and Meiotic recombination 11 (Mre11).
Poxvirus DNA replication.
Bethesda, United States. In Cold Spring Harb Perspect Biol, 2013
A viral FEN1 family protein participates in double-strand break repair.
My journey to DNA repair.
London, United Kingdom. In Genomics Proteomics Bioinformatics, 2013
I discovered the mammalian exonucleases DNase III (TREX1) and IV (FEN1).
Flap endonuclease 1.
Rochester, United States. In Annu Rev Biochem, 2012
First discovered as a structure-specific endonuclease that evolved to cut at the base of single-stranded flaps, flap endonuclease (FEN1) is now recognized as a central component of cellular DNA metabolism.
FEN nucleases: bind, bend, fray, cut.
United States. In Cell, 2011
In this issue, Orans et al. (2011) and Tsutakawa et al. (2011) report exciting insights into the molecular principles governing diverse endo- and exonucleolytic cleavage specificities of members of the RAD2/FEN superfamily of nucleases, which have critical roles in DNA replication and maintenance.