Tolerating DNA damage during eukaryotic chromosome replication.
Madrid, Spain. In Exp Cell Res, 2014
In eukaryotes, the evolutionarily conserved RAD6/RAD18 pathway of DNA damage tolerance overcomes unrepaired DNA lesions that interfere with the progression of replication forks, helping to ensure the completion of chromosome replication and the maintenance of genome stability in every cell cycle.
Regulation and roles of Cdc7 kinase under replication stress.
Olomouc, Czech Republic. In Cell Cycle, 2013
In this review, we first highlight the recent findings on a novel pathway that regulates the stability of the human Cdc7-ASK/Dbf4 complex under replication stress, its interplay with ATR-Chk1 signaling, and significance in the RAD18-dependent DNA damage bypass pathway.
The unnamed complex: what do we know about Smc5-Smc6?
London, United Kingdom. In Chromosome Res, 2008
The structural maintenance of chromosome (SMC) proteins constitute the cores of three protein complexes involved in chromosome metabolism; cohesin, condensin and the Smc5-Smc6 complex.
Regulation of DNA double-strand break repair pathway choice.
Albuquerque, United States. In Cell Res, 2008
While most DSB repair proteins appear to function exclusively in NHEJ or HR, a number of proteins influence both pathways, including the MRE11/RAD50/NBS1(XRS2) complex, BRCA1, histone H2AX, PARP-1, RAD18, DNA-dependent protein kinase catalytic subunit (DNA-PKcs), and ATM.