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Excision repair cross-complementing rodent repair deficiency, complementation group 4

rad1, XPF, ERCC4
The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: ERCC1, CAN, XPC, XPG, XPA
Papers using rad1 antibodies
Repair of deaminated bases in DNA
Supplier
Dianov Grigory L. et al., In Nucleic Acids Research, 2001
... ) and antibodies against XPF were purchased from Abcam.
Papers on rad1
Influence of XPC, XPD, XPF, and XPG gene polymorphisms on the risk and the outcome of acute myeloid leukemia in a Romanian population.
New
Lazar et al., Târgu-Mureş, Romania. In Tumour Biol, 16 Feb 2016
UNASSIGNED: XPC, XPD, XPF, and XPG genes are implicated in the nucleotide excision repair (NER) system.
Increased sensitivity to platinum drugs of cancer cells with acquired resistance to trabectedin.
New
D'Incalci et al., Milano, Italy. In Br J Cancer, 22 Jan 2016
Resistant cells were found to be hypersensitive to UV light and did not express specific proteins involved in the nucleotide excision repair (NER) pathway: XPF and ERCC1 in 402-91/T and XPG in A2780/T.
DNA polymerases δ and λ cooperate in repairing double-strand breaks by microhomology-mediated end-joining in Saccharomyces cerevisiae.
New
Heyer et al., Davis, United States. In Proc Natl Acad Sci U S A, 15 Jan 2016
The association of Pol δ depended on RAD1, which encodes the flap endonuclease needed to cleave MMEJ intermediates before DNA synthesis.
Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism.
New
Liu et al., Shanghai, China. In Int J Biochem Cell Biol, 07 Jan 2016
HY-PDT lowered the removing rate of platinum from DNA and down-regulated the expression of ERCC1 and XPF, two critical enzymes involved in nucleotide excision repair (NER) pathway.
Affected chromosome homeostasis and genomic instability of clonal yeast cultures.
New
Wnuk et al., Rzeszów, Poland. In Curr Genet, 18 Dec 2015
Chromosome-dependent and mutation-dependent changes in DNA (DNA with breaks or with abnormal replication intermediates) were studied using both single-gene deletion haploid mutants (bub1, bub2, mad1, tel1, rad1 and tor1) and diploid cells lacking one active gene of interest, namely BUB1/bub1, BUB2/bub2, MAD1/mad1, TEL1/tel1, RAD1/rad1 and TOR1/tor1 involved in the control of cell cycle progression, DNA repair and the regulation of longevity.
Genetic Polymorphisms in XRCC1, CD3EAP, PPP1R13L, XPB, XPC, and XPF and the Risk of Chronic Benzene Poisoning in a Chinese Occupational Population.
Lu et al., Shenyang, China. In Plos One, 2014
METHODS: Nine single nucleotide polymorphisms (SNPs) of XRCC1 (X-ray repair cross-complementing 1), CD3EAP (CD3e molecule, epsilon associated protein), PPP1R13L (protein phosphatase 1, regulatory subunit 13 like), XPB (Xeroderma pigmentosum group B), XPC (Xeroderma pigmentosum group C) and XPF (Xeroderma pigmentosum group F) were genotyped by the Snapshot and TaqMan-MGB® probe techniques, in a study involving 102 CBP patients and 204 controls.
[Retrospective NGS Study in High-risk Hereditary Cancer Patients at Masaryk Memorial Cancer Institute].
Foretová et al., In Klin Onkol, 2014
Various pathogenic or potentially pathogenic (missense, predicted splice site, in-frame insertion/deletion) mutations were detected in ATM, BRIP1, CDH1, CHEK2, ERCC2, ERCC3, ERCC4, FANCA, MC1R, MEN1, MRE11A, MUTYH, PALB2, RAD51C, RET, SDHB, STK11.
Regulation of ATRIP protein abundance by RAD9 in the DNA damage repair pathway.
Ding et al., Nanchang, China. In Cell Mol Biol (noisy-le-grand), 2014
A number of proteins act in concert with ATR to phosphorylate Chk1, including RAD17, the RAD9-RAD1-HUS1 complex, ATR/ATRIP and TopBp1.
Association of NER pathway gene polymorphisms with susceptibility to laryngeal cancer in a Chinese population.
Liu et al., Harbin, China. In Int J Clin Exp Pathol, 2014
Genotyping of ERCC1 rs11615 and rs2298881, ERCC2 rs13181 and rs50871, ERCC3 rs4150441, ERCC4 rs6498486, ERCC5 rs2094258, XPA rs2808668 and XPC rs2228001 were analyzed by polymerase chain reaction (PCR) coupled with restriction fragment length polymorphism (RFLP).
Association of single nucleotide polymorphisms of DNA repair genes in NER pathway and susceptibility to pancreatic cancer.
Li et al., Zhumadian, China. In Int J Clin Exp Pathol, 2014
In our study, we conducted a case-control study to investigate the association of ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, XPA, XPC and DDB2 gene polymorphisms in the risk of pancreatic cancer.
DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria.
Impact
Garinis et al., Irákleion, Greece. In Cell Metab, 2013
Using mice carrying an ERCC1-XPF DNA repair defect systematically or in adipocytes, we show that DNA damage signaling triggers a chronic autoinflammatory response leading to fat depletion.
Comparison of ERCC1/XPF genetic variation, mRNA and protein levels in women with advanced stage ovarian cancer treated with intraperitoneal platinum.
GeneRIF
Niedernhofer et al., Washington, D.C., United States. In Gynecol Oncol, 2012
There is no evidence that G1244A and T2505 single nucleotide polymorphisms in XPF affect expression of ERCC1.
The Rad1-Rad10 nuclease promotes chromosome translocations between dispersed repeats.
GeneRIF
Symington et al., New York City, United States. In Nat Struct Mol Biol, 2012
Presented is a model for the role of Rad1-Rad10 cleavage in formation of recombinants between dispersed repeats.
Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair.
GeneRIF
Schärer et al., Stony Brook, United States. In J Biol Chem, 2012
Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair
Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability.
GeneRIF
Ivanov et al., Berkeley, United States. In Proc Natl Acad Sci U S A, 2012
Data show models for the ternary PCNA/FEN1/DNA and Rad9-Rad1-Hus1 (9-1-1 complex)/FEN1/DNA assemblies.
Association between XPF polymorphisms and cancer risk: a meta-analysis.
GeneRIF
Wei et al., Shanghai, China. In Plos One, 2011
This meta-analysis suggests a lack of statistical evidence for the association between the four XPF SNPs and overall risk of cancers.
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.
Impact
Patel et al., Cambridge, United Kingdom. In Nat Genet, 2011
Genetic complementation reveals a crucial requirement for Btbd12 (also known as Slx4) to interact with the structure-specific endonuclease Xpf-Ercc1 to promote crosslink repair.
Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial.
Impact
Sonneveld et al., Rotterdam, Netherlands. In Lancet Oncol, 2010
Significant SNPs were noted in inflammatory genes MBL2 (OR 0·49, 95% CI 0·26-0·94; p=3·0×10(-2)) and PPARD (0·35, 0·15-0·83; p=9·1×10(-3)), and DNA repair genes ERCC4 (2·74, 1·56-4·84; p=1·0×10(-3)) and ERCC3 (1·26, 0·75-2·12; p=3·3×10(-3)).
Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.
Impact
Gaillard et al., Marseille, France. In Cell, 2009
Furthermore, we show that SLX4 binds the XPF(ERCC4) and MUS81 subunits of the XPF-ERCC1 and MUS81-EME1 endonucleases and is required for DNA interstrand crosslink repair.
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Impact
Harper et al., Boston, United States. In Cell, 2009
Human SLX4 forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94.
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