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Excision repair cross-complementing rodent repair deficiency, complementation group 4

rad1, XPF, ERCC4
The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: ERCC1, CAN, XPC, XPG, XPA
Papers using rad1 antibodies
Repair of deaminated bases in DNA
Supplier
Dianov Grigory L. et al., In Nucleic Acids Research, 2001
... ) and antibodies against XPF were purchased from Abcam.
Papers on rad1
Genetic variation in platinating agent and taxane pathway genes as predictors of outcome and toxicity in advanced non-small-cell lung cancer.
New
Gupta et al., Minneapolis, United States. In Pharmacogenomics, Sep 2014
With respect to hematological and nonhematological toxicities, SNPs in drug transporters (ABCB1 and ABCG2) were associated with thrombocytopenia, nausea and neutropenia, whereas SNPs in the DNA repair pathway genes ERCC4 and XPC were significantly associated with neutropenia and sensory neuropathy, respectively.
Associations of ERCC4 rs1800067 Polymorphism with Cancer Risk: an Updated Meta-analysis.
New
Yuan et al., Shenyang, China. In Asian Pac J Cancer Prev, Dec 2013
BACKGROUND: RESULTS from previous studies concerning the association of ERCC4 rs1800067 polymorphism with risk of cancer were inconsistent.
Association of DNA repair gene polymorphisms with response to chemotherapy and prognosis of gastric cancer.
New
Luo et al., Guangzhou, China. In Genet Mol Res, Dec 2013
We investigated the correlation between the response to chemotherapy in patients and excision repair cross-complimenta-ry group 1 gene (ERCC1) and xeroderma pigmentosum complemen-tation group F gene (XPF) polymorphisms and the effect of these polymorphisms on the clinical outcome of gastric cancer.
Lack of Association between XPF Polymorphisms and Gastric Cancer Risk: A Meta-Analysis.
New
Wang et al., Shanghai, China. In Oncol Res Treat, Dec 2013
SUMMARY BACKGROUND: Xeroderma pigmentosum complementation group F (XPF or ERCC4) plays a key role in DNA repair that protects against genetic instability and carcinogenesis.
DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria.
New
Impact
Garinis et al., Irákleion, Greece. In Cell Metab, Oct 2013
Using mice carrying an ERCC1-XPF DNA repair defect systematically or in adipocytes, we show that DNA damage signaling triggers a chronic autoinflammatory response leading to fat depletion.
Oxidative-stress-induced epigenetic changes in chronic diabetic complications.
Review
New
Chakrabarti et al., London, Canada. In Can J Physiol Pharmacol, Mar 2013
Oxidative stress also causes DNA damage and activates DNA nucleotide excision repair enzymes including the excision repair cross complimenting 1(ERCC1), ERCC4, and poly(ADP-ribose) polymerase (PARP).
Genetic manipulation in Sulfolobus islandicus and functional analysis of DNA repair genes.
Review
New
She et al., Wuhan, China. In Biochem Soc Trans, Mar 2013
We found that this archaeon may not encode a eukarya-type of NER (nucleotide excision repair) pathway because depleting each of the eukaryal NER homologues XPD, XPB and XPF did not impair the DNA repair capacity in their mutants.
Differential expression of DNA repair genes in Hispanic women with breast cancer.
New
Suarez et al., Ponce, Puerto Rico. In Mol Cancer Biol, Mar 2013
Those candidate genes were CHEK2, EME1 (MMS4L), ERCC3 (XPB), FANCM, H2AFX (H2AX), HMGB1, HUS1, MBD4, NEIL3, PCNA, RAD1, RAD23B, RAD51, RAD54B, RDM1 (RAD52B), SHFM1 (DSS1), TP1, UBE2N (UBC13) and XRCC5 (Ku80).
DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy.
Review
Melton et al., Edinburgh, United Kingdom. In Nucleic Acids Res, 2012
The ERCC1-XPF complex is a structure-specific endonuclease essential for the repair of DNA damage by the nucleotide excision repair pathway.
Comparison of ERCC1/XPF genetic variation, mRNA and protein levels in women with advanced stage ovarian cancer treated with intraperitoneal platinum.
GeneRIF
Niedernhofer et al., Washington, D.C., United States. In Gynecol Oncol, 2012
There is no evidence that G1244A and T2505 single nucleotide polymorphisms in XPF affect expression of ERCC1.
The Rad1-Rad10 nuclease promotes chromosome translocations between dispersed repeats.
GeneRIF
Symington et al., New York City, United States. In Nat Struct Mol Biol, 2012
Presented is a model for the role of Rad1-Rad10 cleavage in formation of recombinants between dispersed repeats.
Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair.
GeneRIF
Schärer et al., Stony Brook, United States. In J Biol Chem, 2012
Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair
Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability.
GeneRIF
Ivanov et al., Berkeley, United States. In Proc Natl Acad Sci U S A, 2012
Data show models for the ternary PCNA/FEN1/DNA and Rad9-Rad1-Hus1 (9-1-1 complex)/FEN1/DNA assemblies.
Host-defense peptides in skin secretions of African clawed frogs (Xenopodinae, Pipidae).
Review
King et al., Al `Ayn, United Arab Emirates. In Gen Comp Endocrinol, 2012
All Xenopus antimicrobial peptides may be classified in the magainin, peptide glycine-leucine-amide (PGLa), caerulein-precursor fragment (CPF), and xenopsin-precursor fragment (XPF) families.
Association between XPF polymorphisms and cancer risk: a meta-analysis.
Review
GeneRIF
Wei et al., Shanghai, China. In Plos One, 2011
This meta-analysis suggests a lack of statistical evidence for the association between the four XPF SNPs and overall risk of cancers.
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.
Impact
Patel et al., Cambridge, United Kingdom. In Nat Genet, 2011
Genetic complementation reveals a crucial requirement for Btbd12 (also known as Slx4) to interact with the structure-specific endonuclease Xpf-Ercc1 to promote crosslink repair.
Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial.
Impact
Sonneveld et al., Rotterdam, Netherlands. In Lancet Oncol, 2010
Significant SNPs were noted in inflammatory genes MBL2 (OR 0·49, 95% CI 0·26-0·94; p=3·0×10(-2)) and PPARD (0·35, 0·15-0·83; p=9·1×10(-3)), and DNA repair genes ERCC4 (2·74, 1·56-4·84; p=1·0×10(-3)) and ERCC3 (1·26, 0·75-2·12; p=3·3×10(-3)).
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Impact
Harper et al., Boston, United States. In Cell, 2009
Human SLX4 forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94.
Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.
Impact
Gaillard et al., Marseille, France. In Cell, 2009
Furthermore, we show that SLX4 binds the XPF(ERCC4) and MUS81 subunits of the XPF-ERCC1 and MUS81-EME1 endonucleases and is required for DNA interstrand crosslink repair.
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