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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 07 Nov 2015.

Excision repair cross-complementing rodent repair deficiency, complementation group 4

rad1, XPF, ERCC4
The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: ERCC1, CAN, XPC, XPG, XPA
Papers using rad1 antibodies
Repair of deaminated bases in DNA
Dianov Grigory L. et al., In Nucleic Acids Research, 2001
... ) and antibodies against XPF were purchased from Abcam.
Papers on rad1
MicroRNA-128 regulates cell cycle, chromosomal stability and DNA repair of mitomycin C-treated lung cancer cells through repressing nonerythroid αII spectrin.
Li et al., Nanjing, China. In Oncotarget, 02 Dec 2015
Finally, miR-128 significantly influenced the interaction of αII Sp/FANCA/XPF complex to limit their DNA repair.
DNA replication restart and cellular dynamics of Hef helicase/nuclease protein in Haloferax volcanii.
Myllykallio et al., Palaiseau, France. In Biochimie, 30 Nov 2015
Here we will described how genetic and imaging studies have revealed the central role of the archaeal helicase/nuclease Hef belonging to the XPF/MUS81/FANCM family of endonucleases in repair of arrested replication forks.
Hyphal branching during arbuscule development requires RAM1.
Harrison et al., Ithaca, United States. In Plant Physiol, 28 Nov 2015
Furthermore, RAM1 regulates expression of a GRAS transcription factor RAD1. RAD1 is also required for AM symbiosis and rad1 mutants show reduced colonization.
In vitro chromatin templates to study nucleotide excision repair.
Liu, West Lafayette, United States. In Dna Repair (amst), 22 Nov 2015
At least three systems have been used to analyze the effect of nucleosome folding on nucleotide excision repair (NER) in vitro: (a) human cell extracts that have to rely on labeling of repair synthesis to monitor DNA repair, due to very low repair efficacy; (b) Xenopus oocyte nuclear extracts, that have very robust DNA repair efficacy, have been utilized to follow direct removal of DNA damage; (c) six purified human DNA repair factors (RPA, XPA, XPC, TFIIH, XPG, and XPF-ERCC1) that have been used to reconstitute excision repair in vitro.
Physical interaction between SLX4 (FANCP) and XPF (FANCQ) proteins and biological consequences of interaction-defective missense mutations.
Moriya et al., Stony Brook, United States. In Dna Repair (amst), 30 Oct 2015
UNASSIGNED: SLX4 (FANCP) and XPF (FANCQ) proteins interact with each other and play a vital role in the Fanconi anemia (FA) DNA repair pathway.
The ERCC1 and ERCC4 (XPF) genes and gene products.
Wood et al., United States. In Gene, 15 Oct 2015
The ERCC1 and ERCC4 genes encode the two subunits of the ERCC1-XPF nuclease.
Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes.
Moskalev et al., Moscow, Russia. In Sci Rep, Dec 2014
Overexpressed genes included those involved in recognition of DNA damage (homologs of HUS1, CHK2), nucleotide and base excision repair (homologs of XPF, XPC and AP-endonuclease-1), and repair of double-stranded DNA breaks (homologs of BRCA2, XRCC3, KU80 and WRNexo).
DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria.
Garinis et al., Irákleion, Greece. In Cell Metab, 2013
Using mice carrying an ERCC1-XPF DNA repair defect systematically or in adipocytes, we show that DNA damage signaling triggers a chronic autoinflammatory response leading to fat depletion.
Oxidative-stress-induced epigenetic changes in chronic diabetic complications.
Chakrabarti et al., London, Canada. In Can J Physiol Pharmacol, 2013
Oxidative stress also causes DNA damage and activates DNA nucleotide excision repair enzymes including the excision repair cross complimenting 1(ERCC1), ERCC4, and poly(ADP-ribose) polymerase (PARP).
Genetic manipulation in Sulfolobus islandicus and functional analysis of DNA repair genes.
She et al., Wuhan, China. In Biochem Soc Trans, 2013
We found that this archaeon may not encode a eukarya-type of NER (nucleotide excision repair) pathway because depleting each of the eukaryal NER homologues XPD, XPB and XPF did not impair the DNA repair capacity in their mutants.
DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy.
Melton et al., Edinburgh, United Kingdom. In Nucleic Acids Res, 2012
The ERCC1-XPF complex is a structure-specific endonuclease essential for the repair of DNA damage by the nucleotide excision repair pathway.
Comparison of ERCC1/XPF genetic variation, mRNA and protein levels in women with advanced stage ovarian cancer treated with intraperitoneal platinum.
Niedernhofer et al., Washington, D.C., United States. In Gynecol Oncol, 2012
There is no evidence that G1244A and T2505 single nucleotide polymorphisms in XPF affect expression of ERCC1.
The Rad1-Rad10 nuclease promotes chromosome translocations between dispersed repeats.
Symington et al., New York City, United States. In Nat Struct Mol Biol, 2012
Presented is a model for the role of Rad1-Rad10 cleavage in formation of recombinants between dispersed repeats.
Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair.
Schärer et al., Stony Brook, United States. In J Biol Chem, 2012
Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair
Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability.
Ivanov et al., Berkeley, United States. In Proc Natl Acad Sci U S A, 2012
Data show models for the ternary PCNA/FEN1/DNA and Rad9-Rad1-Hus1 (9-1-1 complex)/FEN1/DNA assemblies.
Association between XPF polymorphisms and cancer risk: a meta-analysis.
Wei et al., Shanghai, China. In Plos One, 2011
This meta-analysis suggests a lack of statistical evidence for the association between the four XPF SNPs and overall risk of cancers.
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.
Patel et al., Cambridge, United Kingdom. In Nat Genet, 2011
Genetic complementation reveals a crucial requirement for Btbd12 (also known as Slx4) to interact with the structure-specific endonuclease Xpf-Ercc1 to promote crosslink repair.
Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial.
Sonneveld et al., Rotterdam, Netherlands. In Lancet Oncol, 2010
Significant SNPs were noted in inflammatory genes MBL2 (OR 0·49, 95% CI 0·26-0·94; p=3·0×10(-2)) and PPARD (0·35, 0·15-0·83; p=9·1×10(-3)), and DNA repair genes ERCC4 (2·74, 1·56-4·84; p=1·0×10(-3)) and ERCC3 (1·26, 0·75-2·12; p=3·3×10(-3)).
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Harper et al., Boston, United States. In Cell, 2009
Human SLX4 forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94.
Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.
Gaillard et al., Marseille, France. In Cell, 2009
Furthermore, we show that SLX4 binds the XPF(ERCC4) and MUS81 subunits of the XPF-ERCC1 and MUS81-EME1 endonucleases and is required for DNA interstrand crosslink repair.
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