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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 May 2015.

Excision repair cross-complementing rodent repair deficiency, complementation group 4

rad1, XPF, ERCC4
The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: ERCC1, CAN, XPC, XPG, XPA
Papers using rad1 antibodies
Repair of deaminated bases in DNA
Supplier
Dianov Grigory L. et al., In Nucleic Acids Research, 2001
... ) and antibodies against XPF were purchased from Abcam.
Papers on rad1
SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates.
New
Liu et al., Baltimore, United States. In Nucleic Acids Res, 18 Jun 2015
UNASSIGNED: SLX4 assembles a toolkit of endonucleases SLX1, MUS81 and XPF, which is recruited to telomeres via direct interaction of SLX4 with TRF2.
HUS1 regulates in vivo responses to genotoxic chemotherapies.
New
Weiss et al., Ithaca, United States. In Oncogene, 27 May 2015
Optimal ATR signaling requires the RAD9A-RAD1-HUS1 (9-1-1) complex, a toroidal clamp that is loaded at damage sites and scaffolds signaling and repair factors.
Genome Protection by the 9-1-1 Complex Subunit HUS1 Requires Clamp Formation, DNA Contacts, and ATR Signaling-Independent Effector Functions.
New
Weiss et al., United States. In J Biol Chem, 24 May 2015
UNASSIGNED: The RAD9A-HUS1-RAD1 (9-1-1) complex is a heterotrimeric clamp that promotes checkpoint signaling and repair at DNA damage sites.
Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance.
New
Melton et al., Edinburgh, United Kingdom. In Dna Repair (amst), 22 May 2015
UNASSIGNED: ERCC1-XPF is a structure-specific endonuclease that is required for the repair of DNA lesions, generated by the widely used platinum-containing cancer chemotherapeutics such as cisplatin, through the Nucleotide Excision Repair and Interstrand Crosslink Repair pathways.
Influence of Morinda citrifolia (Noni) on Expression of DNA Repair Genes in Cervical Cancer Cells.
New
Singh et al., New Delhi, India. In Asian Pac J Cancer Prev, Dec 2014
RESULTS: The expression of nucleotide excision repair genes ERCC1, ERCC2, and ERCC4 and base excision repair gene XRCC1 was increased 4 fold, 8.9 fold, 4 fold, and 5.5 fold, respectively, on treatment with Noni as compared to untreated controls (p<0.05).
DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria.
Impact
Garinis et al., Irákleion, Greece. In Cell Metab, 2013
Using mice carrying an ERCC1-XPF DNA repair defect systematically or in adipocytes, we show that DNA damage signaling triggers a chronic autoinflammatory response leading to fat depletion.
Oxidative-stress-induced epigenetic changes in chronic diabetic complications.
Review
Chakrabarti et al., London, Canada. In Can J Physiol Pharmacol, 2013
Oxidative stress also causes DNA damage and activates DNA nucleotide excision repair enzymes including the excision repair cross complimenting 1(ERCC1), ERCC4, and poly(ADP-ribose) polymerase (PARP).
Genetic manipulation in Sulfolobus islandicus and functional analysis of DNA repair genes.
Review
She et al., Wuhan, China. In Biochem Soc Trans, 2013
We found that this archaeon may not encode a eukarya-type of NER (nucleotide excision repair) pathway because depleting each of the eukaryal NER homologues XPD, XPB and XPF did not impair the DNA repair capacity in their mutants.
DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy.
Review
Melton et al., Edinburgh, United Kingdom. In Nucleic Acids Res, 2012
The ERCC1-XPF complex is a structure-specific endonuclease essential for the repair of DNA damage by the nucleotide excision repair pathway.
Comparison of ERCC1/XPF genetic variation, mRNA and protein levels in women with advanced stage ovarian cancer treated with intraperitoneal platinum.
GeneRIF
Niedernhofer et al., Washington, D.C., United States. In Gynecol Oncol, 2012
There is no evidence that G1244A and T2505 single nucleotide polymorphisms in XPF affect expression of ERCC1.
The Rad1-Rad10 nuclease promotes chromosome translocations between dispersed repeats.
GeneRIF
Symington et al., New York City, United States. In Nat Struct Mol Biol, 2012
Presented is a model for the role of Rad1-Rad10 cleavage in formation of recombinants between dispersed repeats.
Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair.
GeneRIF
Schärer et al., Stony Brook, United States. In J Biol Chem, 2012
Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair
Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability.
GeneRIF
Ivanov et al., Berkeley, United States. In Proc Natl Acad Sci U S A, 2012
Data show models for the ternary PCNA/FEN1/DNA and Rad9-Rad1-Hus1 (9-1-1 complex)/FEN1/DNA assemblies.
Host-defense peptides in skin secretions of African clawed frogs (Xenopodinae, Pipidae).
Review
King et al., Al `Ayn, United Arab Emirates. In Gen Comp Endocrinol, 2012
All Xenopus antimicrobial peptides may be classified in the magainin, peptide glycine-leucine-amide (PGLa), caerulein-precursor fragment (CPF), and xenopsin-precursor fragment (XPF) families.
Association between XPF polymorphisms and cancer risk: a meta-analysis.
Review
GeneRIF
Wei et al., Shanghai, China. In Plos One, 2011
This meta-analysis suggests a lack of statistical evidence for the association between the four XPF SNPs and overall risk of cancers.
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.
Impact
Patel et al., Cambridge, United Kingdom. In Nat Genet, 2011
Genetic complementation reveals a crucial requirement for Btbd12 (also known as Slx4) to interact with the structure-specific endonuclease Xpf-Ercc1 to promote crosslink repair.
Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial.
Impact
Sonneveld et al., Rotterdam, Netherlands. In Lancet Oncol, 2010
Significant SNPs were noted in inflammatory genes MBL2 (OR 0·49, 95% CI 0·26-0·94; p=3·0×10(-2)) and PPARD (0·35, 0·15-0·83; p=9·1×10(-3)), and DNA repair genes ERCC4 (2·74, 1·56-4·84; p=1·0×10(-3)) and ERCC3 (1·26, 0·75-2·12; p=3·3×10(-3)).
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Impact
Harper et al., Boston, United States. In Cell, 2009
Human SLX4 forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94.
Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.
Impact
Gaillard et al., Marseille, France. In Cell, 2009
Furthermore, we show that SLX4 binds the XPF(ERCC4) and MUS81 subunits of the XPF-ERCC1 and MUS81-EME1 endonucleases and is required for DNA interstrand crosslink repair.
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