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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ras-related C3 botulinum toxin substrate 2

Rac2, small G protein, G x, en-7
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rhodopsin, V1a, Akt, CAN, Actin
Papers using Rac2 antibodies
Self-reactive T cells can escape clonal deletion in T-cell receptor V beta 8.1 transgenic mice.
Supplier
Unutmaz Derya, In PLoS ONE, 1989
... Anti-phospho MKK3, anti-MKK3, Anti-p38MAPK, and phospho-p38MAPK Abs were purchased from Cell Signaling (Beverly, MA), anti-Rac2 Ab was purchased from Abcam (Cambridge, MA), anti-Rac1 Ab ...
Papers on Rac2
Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation.
New
Snyder et al., Baltimore, United States. In Mol Psychiatry, Feb 2016
Nitrosylated GAPDH complexes with the ubiquitin-E3-ligase Siah1 and Rheb, a small G protein that activates mTOR.
Calnuc function in endosomal sorting of lysosomal receptors.
New
Lavoie et al., Sherbrooke, Canada. In Traffic, Feb 2016
Indeed, we demonstrated that Calnuc depletion impairs the activation and membrane association of Rab7, a small G protein required for the endosomal recruitment of retromers.
The hematopoietic oncoprotein FOXP1 promotes tumor cell survival in diffuse large B-cell lymphoma by repressing S1PR2 signaling.
New
Müller et al., Zürich, Switzerland. In Blood, Feb 2016
The pro-apoptotic effects of S1PR2 are phenocopied by ectopic expression of the small G-protein Gα13, but are independent of AKT signaling.
Rasd1, a small G protein with a big role in the hypothalamic response to neuronal activation.
New
Murphy et al., Ribeirão Preto, Brazil. In Mol Brain, Dec 2015
BACKGROUND: Rasd1 is a member of the Ras family of monomeric G proteins that was first identified as a dexamethasone inducible gene in the pituitary corticotroph cell line AtT20.
The multifaceted role of PIP2 in leukocyte biology.
Review
New
Galandrini et al., Roma, Italy. In Cell Mol Life Sci, Dec 2015
The interplay between PIP2, lipid-modifying enzymes and small G protein-regulated signals is also discussed.
Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells.
New
Kortholt et al., Groningen, Netherlands. In Bmc Cell Biol, Dec 2015
BACKGROUND: The small G-protein Rap1 is an important regulator of cellular adhesion in Dictyostelium, however so far the downstream signalling pathways for cell adhesion are not completely characterized.
Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network.
New
Impact
Cavé et al., Paris, France. In Nat Genet, Nov 2015
Multiple concomitant genetic hits targeting the RAS pathway were identified in 13 of 78 cases (17%), disproving the concept of mutually exclusive RAS pathway mutations and defining new pathways activated in JMML involving phosphoinositide 3-kinase (PI3K) and the mTORC2 complex through RAC2 mutation.
Gated entry into the ciliary compartment.
Review
New
Verhey et al., Ann Arbor, United States. In Cell Mol Life Sci, Nov 2015
Specifically, nucleoporins of the CPC limit the diffusional entry of cytosolic proteins in a size-dependent manner and enable the active transport of large molecules and complexes via targeting signals, importins, and the small G protein Ran.
Universal allosteric mechanism for Gα activation by GPCRs.
New
Impact
Babu et al., Cambridge, United Kingdom. In Nature, Sep 2015
Comparison of Gα with the small G protein Ras reveals how the evolution of short segments that undergo disorder-to-order transitions can decouple regions important for allosteric activation from receptor binding specificity.
Structures of Ras superfamily effector complexes: What have we learnt in two decades?
Review
New
Owen et al., Cambridge, United Kingdom. In Crit Rev Biochem Mol Biol, Mar 2015
The first structure of a small G protein-effector complex, that of Rap1A with c-Raf1, was published 20 years ago.
The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels.
Review
So et al., Seoul, South Korea. In Channels (austin), 2014
We discuss potential roles for Rasd1 small G protein and leptin in channel activation in addition to their known role in cellular signaling.
Crossroads of PI3K and Rac pathways.
Review
Hirsch et al., Torino, Italy. In Small Gtpases, 2014
PI3Ks are lipid kinases that produce phosphorylated lipids which, in turn, transduce extracellular cues within the cell, while Rac is a small G protein that impacts on actin organization.
Cytokinesis failure triggers hippo tumor suppressor pathway activation.
Impact
Pellman et al., Boston, United States. In Cell, 2014
Induction of the Hippo pathway is triggered in part by extra centrosomes, which alter small G protein signaling and activate LATS2 kinase.
A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens.
Impact
Sabatini et al., Cambridge, United States. In Nat Cell Biol, 2013
To gain more insight into the cellular mechanisms mediating BFA toxicity, we conducted a genome-wide haploid genetic screen that led to the identification of the small G protein ADP-ribosylation factor 4 (ARF4).
Rap2A links intestinal cell polarity to brush border formation.
Impact
Bos et al., Utrecht, Netherlands. In Nat Cell Biol, 2012
Here, we identify the small G protein Rap2A as a molecular link that couples the formation of microvilli directly to the preceding cell polarization.
Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors.
GeneRIF
Skorski et al., Philadelphia, United States. In Blood, 2012
Rac2 GTPase alters mitochondrial membrane potential and electron flow through the mitochondrial respiratory chain complex III, generating high levels of reactive oxygen species in chronic-phase CML stem cells and primitive leukemia progenitor cells.
Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2.
GeneRIF
Gomez-Cambronero et al., Dayton, United States. In Proc Natl Acad Sci U S A, 2012
Data show that the Phospholipase D2 (PLD2)-GTPase Rac2 protein-protein interaction is sufficient for the guanine nucleotide exchange factor (GEF) function.
Rac regulates PtdInsP₃ signaling and the chemotactic compass through a redox-mediated feedback loop.
GeneRIF
Glogauer et al., Toronto, Canada. In Blood, 2012
Using Rac mutants that are defective in their ability to activate NOX2, we show that Rac regulates a redox-mediated feedback loop that mediates directional migration of neutrophils.
Rac deletion in osteoclasts causes severe osteopetrosis.
GeneRIF
Teitelbaum et al., Saint Louis, United States. In J Cell Sci, 2011
Deletion of Rac1 and Rac2 in osteoclasts causes severe osteopetrosis.
Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway.
Impact
GeneRIF
Stuart et al., Boston, United States. In Immunity, 2011
CNF1 modified Rac2, which then interacted with the innate immune adaptors IMD and Rip1-Rip2 in flies and mammalian cells, respectively, to drive an immune response
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