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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ras-related C3 botulinum toxin substrate 1

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: Akt, Rhodopsin, ACID, CAN, Actin
Papers using Rac1 antibodies
Inactivation of Adenosine A2A Receptor Attenuates Basal and Angiotensin II-induced ROS Production by Nox2 in Endothelial Cells*
Li Jian-Mei et al., In The Journal of Biological Chemistry, 2007
... , rac1, and A2AR were from Santa Cruz Biotechnology.
Rac and Rap GTPase activation assays.
Hartl Dominik, In PLoS ONE, 2006
... (Thr183/Thr185,) SAPK/JNK (56G8), and FAK were from Cell Signaling (Danvers, MA); paxillin, E-cadherin, MKK2, and Rac1 from BD Biosciences (Franklin Lakes, NJ); MKK6 ...
A molecular mechanism directly linking E-cadherin adhesion to initiation of epithelial cell surface polarity
Menke Andre et al., In Cell Communication and Signaling : CCS, 2006
... PANC-1 cells stably transfected with pEGFP/HA-Rac1(V12), pEGFP/Rac1(N17) or pEGFP-C3 (Clontech) were established as described ...
uPAR induces epithelial–mesenchymal transition in hypoxic breast cancer cells
Gonias Steven L. et al., In The Journal of Cell Biology, 2005
... Rac1- and HIF-1α–specific monoclonal antibodies were purchased from BD Biosciences.
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Papers on Rac1
CC chemokine ligand 18(CCL18) promotes migration and invasion of lung cancer cells by binding to Nir1 through Nir1-ELMO1/DOC180 signaling pathway.
Zhang et al., Weifang, China. In Mol Carcinog, Feb 2016
In addition, CCL18 is capable of modulating cell migration and invasion by regulating the activation of RAC1 which resulted in cytoskeleton reorganization in an ELMO1 dependent manner.
Novel copy number variants and major limb reduction malformation: Report of three cases.
Alkuraya et al., Riyadh, Saudi Arabia. In Am J Med Genet A, Feb 2016
These include a patient with hypoplastic phalanges and absent hallux bilaterally with de novo deletion of 11.9 Mb on 7p21.1-22.1 spanning 63 genes including RAC1, another patient with severe Holt-Oram syndrome and a large de novo deletion 2.2 Mb on 12q24.13-24.21
Targeted next generation sequencing reveals unique mutation profile of primary melanocytic tumors of the central nervous system.
Griewank et al., Essen, Germany. In J Neurooncol, Feb 2016
Electrospun polylactic acid and polyvinyl alcohol fibers as efficient and stable nanomaterials for immobilization of lipases.
Marosi et al., Budapest, Hungary. In Bioprocess Biosyst Eng, Feb 2016
The biocatalytic performance of the resulting membrane biocatalysts was evaluated in the kinetic resolution of racemic 1-phenylethanol (rac-1) and 1-phenylethyl acetate (rac-2).
Novel hepatic microRNAs upregulated in human nonalcoholic fatty liver disease.
Olkkonen et al., Helsinki, Finland. In Physiol Rep, Jan 2016
Consistent transcriptome changes were observed in IHH transfected with miR-576-5p, and western analysis revealed a marked reduction of the RAC1 protein belonging to several miR-576-5p target pathways.
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
Taylor et al., New York City, United States. In Nat Biotechnol, Dec 2015
In total, 243 hotspots were novel and appeared to affect a broad spectrum of molecular function, including hotspots at paralogous residues of Ras-related small GTPases RAC1 and RRAS2.
Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway.
Bastian et al., San Francisco, United States. In Nat Genet, Oct 2015
Instead, other genetic alterations known to activate the MAPK and PI3K signaling cascades were identified in 73% of samples, affecting NF1, CBL, ERBB2, MAP2K1, MAP3K1, BRAF, EGFR, PTPN11, MET, RAC1, SOS2, NRAS and PIK3CA, some of which are candidates for targeted therapies.
Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.
Notarangelo et al., Worcester, United States. In N Engl J Med, Jul 2015
RAC1 activation was impaired in the T cells.
Alternative 3' UTRs act as scaffolds to regulate membrane protein localization.
Mayr et al., New York City, United States. In Nature, Jul 2015
This facilitates interaction of SET with the newly translated cytoplasmic domains of CD47 and results in subsequent translocation of CD47 to the plasma membrane via activated RAC1 (ref.
The genetic basis of new treatment modalities in melanoma.
Kunz, Leipzig, Germany. In Curr Drug Targets, 2014
At the same time, high throughput sequencing studies of melanoma unraveled a series of new treatment candidates for future treatment approaches such as ERBB4, GRIN2A, GRM3, and RAC1.
Metabolism and insulin signaling in common metabolic disorders and inherited insulin resistance.
Højlund, Odense, Denmark. In Dan Med J, 2014
Insulin in physiological concentrations stimulates glucose uptake in human skeletal muscle in vivo by activation of the insulin signaling cascade to glucose transport through the enzymes IRS1, PI3K, Akt2, AS160/TBC1D4 and RAC1, and to glycogen synthesis through Akt2, inhibition of GSK3 and activation of glycogen synthase (GS) via dephosphorylation of serine residues in both the NH2-terminal (site 2+2a) and the COOH-terminal end (site 3a+3b).
Oncogenes in melanoma: an update.
Kunz, Leipzig, Germany. In Eur J Cell Biol, 2014
A number of new oncogene candidates such as MAPK1/2, ERBB4, GRIN2A, GRM3, RAC1, and PREX2 were identified.
Interaction of LRRK2 with kinase and GTPase signaling cascades.
Wolozin et al., Boston, United States. In Front Mol Neurosci, 2013
Binding to GTPases, GTPase-activating proteins and GTPase exchange factors are another strong theme in LRRK2 biology, with LRRK2 binding to rac1, cdc42, rab5, rab7L1, endoA, RGS2, ArfGAP1, and ArhGEF7.
RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.
Downward et al., London, United Kingdom. In Cell, 2013
Unexpectedly, RAS is unable to interact with p110β, but instead RAC1 and CDC42 from the RHO subfamily of small GTPases bind and activate p110β via its RBD.
Integrin β1: A Mechanosignaling Sensor Essential for Connective Tissue Deposition by Fibroblasts.
Leask, London, Canada. In Adv Wound Care (new Rochelle), 2013
The mechanism underlying these activities of integrin β1 appears to involve its ability to (1) mediate activation of latent transforming growth factor beta-1 via ECM contraction and (2) modulate collagen production via a focal adhesion kinase/rac1/nicotinamide adenine dinucleotide phosphate oxidase (NOX)/reactive oxygen species (ROS) pathway.
Traumatic noise activates Rho-family GTPases through transient cellular energy depletion.
Sha et al., Charleston, United States. In J Neurosci, 2012
Following traumatic noise, levels of active Rac1 increase in auditory hair cells.
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Halaban et al., New Haven, United States. In Nat Genet, 2012
Recurrent somatic RAC1 mutations in melanoma.
Angiotensin-II and MARCKS: a hydrogen peroxide- and RAC1-dependent signaling pathway in vascular endothelium.
Michel et al., Boston, United States. In J Biol Chem, 2012
a critical role for H(2)O(2) in angiotensin-II signaling to the endothelial cytoskeleton in a novel pathway that is critically dependent on MARCKS, Rac1, and c-Abl.
Interleukin-8 induces the endothelial cell migration through the Rac 1/RhoA-p38MAPK pathway.
Liu et al., Chengdu, China. In Eur Rev Med Pharmacol Sci, 2012
IL-8-Rac1/RhoA-p38MAPK signaling pathway plays a vital role in the IL-8-induced endothelial cell migration.
Activation of Stat3 in endothelial cells following hypoxia-reoxygenation is mediated by Rac1 and protein Kinase C.
Becker et al., Baltimore, United States. In Biochim Biophys Acta, 2012
Stat3 forms a multiprotein complex with Rac1 and PKC in an hypoxia-reoxygenation-dependent manner.
More papers using Rac1 antibodies
p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation
Tsukita Sachiko et al., In The Journal of Cell Biology, 2005
... (Santa Cruz Biotechnology, Inc.), anti-p38, anti–phospho p38 (Cell Signaling Technology), rabbit anti–claudin-3 pAb (Invitrogen), mouse anti-Rac1 mAb (Millipore), mouse anti-desmoplakin mAb (Progen), mouse anti-Trio pAb (Abnova), and mouse and rabbit ...
RhoGDIbeta lacking the N-terminal regulatory domain suppresses metastasis by promoting anoikis in v-src-transformed cells
Yang Jaw-Ji et al., In Journal of Biomedical Science, 2005
... agarose gel, transferred to a nylon filter, and then hybridized with a probe corresponding to the full-length Rac1 cDNA labeled using the NEBlot random labeling kit (New England BioLabs) in the presence of ...
Two distinct cytoplasmic regions of the β2 integrin chain regulate RhoA function during phagocytosis
Caron Emmanuelle et al., In The Journal of Cell Biology, 2004
... The antibodies used in this study were mouse anti-Rac1 (clone 23A8; Upstate Biotechnology), anti-GFP (JL-8; CLONTECH Laboratories, Inc.), anti-myc (9E10; ...
Spectral imaging and its applications in live cell microscopy
Harigaya Kenichi et al., In Acta Histochemica et Cytochemica, 2002
... The following antibodies were used: anti-Rac1) (BD Biosciences Pharmingen, San Diego, CA, ...
Autocrine laminin-5 ligates α6β4 integrin and activates RAC and NFκB to mediate anchorage-independent survival of mammary tumors
Weaver Valerie M. et al., In The Journal of Cell Biology, 2002
... (Santa Cruz Biotechnology, Inc.) and clone 20 (BD Biosciences); cytokeratin 18, clone RCK106 (BD Biosciences); RAC1, clone 102 (BD Biosciences); c-myc, clone 9E10 (Oncogene ...
Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts
Matsumura Fumio et al., In The Journal of Cell Biology, 2002
... National Institutes of Health, Bethesda, MD); an mAb against smooth/nonmuscle myosin heavy chain (Immunotech); a monoclonal anti-Rac1 antibody (BD Biosciences); and a monoclonal anti-vinculin antibody ...
uPAR promotes formation of the p130Cas–Crk complex to activate Rac through DOCK180
Marshall Christopher J. et al., In The Journal of Cell Biology, 2002
... The following antibodies were used: anti-Rac1 (clone 23A8; Fitzgerald), anti-uPAR (R&D Systems), anti-GAPDH ...
Spatiotemporal regulation of moesin phosphorylation and rear release by Rho and serine/threonine phosphatase during neutrophil migration
Huttenlocher Anna et al., In The Journal of Cell Biology, 2001
... mouse antivinculin clone VIN-11-5 and mouse anti–β-actin clone AC-15 (Sigma-Aldrich), rabbit anti-RhoA (67B9) and rabbit anti-Rac1/2/3 (L129; Cell Signaling Technology), goat anti–rabbit Alexa ...
Rho GTPase signalling pathways in the morphological changes associated with apoptosis
Zhang Zhigang et al., In Tumour Biology, 2001
... Mouse monoclonal antibodies used in this study were directed against Rac1 (Merck Millipore, Danvers, MA), tubulin ...
Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence
Sessa William C. et al., In The Journal of Cell Biology, 1999
... The Rac1 antibody was obtained from BD Biosciences.
Growth arrest and cell death in the breast tumor cell in response to ionizing radiation and chemotherapeutic agents which induce DNA damage
Cowan Kenneth H et al., In Breast Cancer Research : BCR, 1999
... Rac1-specific inhibitor NSC23766 [36] was obtained from Tocris Biosciences (Ellisville, MO, USA) ...
Regulation of Rac1 activation by the low density lipoprotein receptor–related protein
Gonias Steven L. et al., In The Journal of Cell Biology, 1995
... Rac1-specific mAb was purchased from BD Biosciences.
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