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Rabphilin 3A

rabphilin-3A
binds Ca2+ and phospholipids [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Rab3A, Rab5, CAN, C2A, ACID
Papers on rabphilin-3A
Long-term exposure to high glucose increases the content of several exocytotic proteins and of vesicular GABA transporter in cultured retinal neural cells.
New
Ambrósio et al., Coimbra, Portugal. In Neurosci Lett, Sep 2015
The protein content and distribution of SNARE proteins (SNAP-25, syntaxin-1, VAMP-2), synapsin-1, synaptotagmin-1, rabphilin 3a, VGluT-1 and VGAT, were evaluated by western blotting and immunocytochemistry.
Rabphilin-3A as a Targeted Autoantigen in Lymphocytic Infundibulo-neurohypophysitis.
New
Oiso et al., Nagoya, Japan. In J Clin Endocrinol Metab, Jul 2015
RESULTS: Rabphilin-3A proved to be the most diagnostically useful autoantigen.
Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex.
Gardoni et al., Milano, Italy. In Nat Commun, 2014
Here, we identify Rabphilin 3A (Rph3A) as a new GluN2A subunit-binding partner.
Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Aβ burden.
Lai et al., Singapore, Singapore. In Neurochem Int, 2014
However, the status of rabphilin 3A (RPH3A), which interacts with the SNARE complex and regulates synaptic vesicle exocytosis and Ca(2+)-triggered neurotransmitter release, is at present unclear.
Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1.
Corbalán-García et al., Murcia, Spain. In Proc Natl Acad Sci U S A, 2014
Here, the use of a free-mounting system has enabled us to capture an intermediate state of Ca(2+) binding to the C2A domain of rabphilin 3A that suggests a different mechanism of ion interaction.
A single in vivo cocaine administration impairs 5-HT(1B) receptor-induced long-term depression in the nucleus accumbens.
Hsu et al., Tainan City, Taiwan. In J Neurochem, 2013
Cocaine treatment resulted in increased phosphorylation of presynaptic proteins, rabphilin 3A and synapsin 1, and significantly attenuated CP 93129-induced decrease in rabphilin 3A and synapsin 1 phosphorylation.
Constitutive activity of the A2A adenosine receptor and compartmentalised cyclic AMP signalling fine-tune noradrenaline release.
Schicker et al., Vienna, Austria. In Purinergic Signal, 2012
phosphorylation of CREB, of Rabphilin3A) were refractory to constitutive activation.
MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway.
Váradi et al., Bristol, United Kingdom. In Mol Biol Cell, 2012
Glucose-stimulated insulin secretion is augmented by incretin hormones, which increase cAMP levels and leads to MyRIP phosphorylation, its interaction with BR-MyoVa, and phosphorylation of the BR-MyoVa receptor rabphilin-3A (Rph-3A).
Molecular mechanism of myosin Va recruitment to dense core secretory granules.
Váradi et al., Bristol, United Kingdom. In Traffic, 2012
These results indicate the existence of at least another binding partner of BR-MyoVa that was identified as rabphilin-3A (Rph-3A).
Detection of autoantibodies against Rabphilin-3A-like protein as a potential biomarker in patient's sera of colorectal cancer.
Chan et al., Taiwan. In Clin Chim Acta, 2011
BACKGROUND: Rabphilin-3A-like (RPH3AL) protein functions in the regulation of hormone exocytosis, and mutations in the RPHA3L gene have been associated with tumorigenesis in colorectal cancer (CRC).
Long-term exposure to high glucose induces changes in the content and distribution of some exocytotic proteins in cultured hippocampal neurons.
Ambrósio et al., Coimbra, Portugal. In Neuroscience, 2011
The protein levels of vesicle-associated membrane protein-2 (VAMP-2), synaptosomal-associated protein-25 (SNAP-25), syntaxin-1, synapsin-1, synaptophysin, synaptotagmin-1, rabphilin 3a, and also of vesicular glutamate and GABA transporters (VGluT-1 and VGAT), were evaluated by immunoblotting, and its localization was analyzed by immunocytochemistry.
Diabetes differentially affects the content of exocytotic proteins in hippocampal and retinal nerve terminals.
Ambrósio et al., Coimbra, Portugal. In Neuroscience, 2010
The content of synaptotagmin-1 and rabphilin 3a in nerve terminals of both tissues was not affected.
DOC2B, C2 domains, and calcium: A tale of intricate interactions.
Review
Ashery et al., Tel Aviv-Yafo, Israel. In Mol Neurobiol, 2010
Sequence alignment of the tandem C2 protein family in mouse revealed high homology (81%) between rabphilin-3A and DOC2B proteins.
Structural determinants for Ca2+ and phosphatidylinositol 4,5-bisphosphate binding by the C2A domain of rabphilin-3A.
GeneRIF
Becker et al., Göttingen, Germany. In J Biol Chem, 2009
Structural determinants for Ca2+ and phosphatidylinositol 4,5-bisphosphate binding by the C2A domain of rabphilin-3A.
In-depth fluorescence lifetime imaging analysis revealing SNAP25A-Rabphilin 3A interactions.
GeneRIF
Yang et al., Taipei, Taiwan. In Microsc Microanal, 2008
Interactions of SNAP25A and RPH3A take place at cell surface during stimulated exocytosis.
The Rab27 effector Rabphilin, unlike Granuphilin and Noc2, rapidly exchanges between secretory granules and cytosol in PC12 cells.
GeneRIF
Burgoyne et al., Liverpool, United Kingdom. In Biochem Biophys Res Commun, 2008
Three Rab3/27 effectors, Granuphilin, Noc2, and Rabphilin, in PC12 cells using fluorescence recovery after photobleaching of EGFP-tagged proteins.
The PIP2 binding mode of the C2 domains of rabphilin-3A.
GeneRIF
Becker et al., Göttingen, Germany. In Protein Sci, 2008
different PIP2 headgroup recognition modes suggest that PIP2 is a target of the C2A domain of rabphilin-3A while this phospholipid is an effector of the C2B domain
Clinical significance of a novel single nucleotide polymorphism in the 5' untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma.
GeneRIF
Manne et al., Birmingham, United States. In Front Biosci, 2007
analysis of a novel single nucleotide polymorphism in the 5' untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma
Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p.
Impact
Hurley et al., Bethesda, United States. In Cell, 1999
The core secondary structures are similar to a rabphilin-3A Zn2+-binding domain and to the C1 and LIM domains.
Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A.
Impact
Brunger et al., New Haven, United States. In Cell, 1999
The crystal structure of activated Rab3A/GTP/Mg2+ bound to the effector domain of rabphilin-3A was solved to 2.6 A resolution.
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