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RUN and FYVE domain containing 1

Rabip4, RUFY1
This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: Rab4, EEA1, Rab5, ACID, Transferrin
Papers on Rabip4
Intracellular periodontal pathogen exploits recycling pathway to exit from infected cells.
New
Amano et al., Suita, Japan. In Cell Microbiol, Dec 2015
VAMP2 forms a complex with EXOC2/Sec5 and EXOC3/Sec6, whereas Rab4A mediates dissociation of the EXOC complex followed by recruitment of RUFY1/Rabip4, Rab4A effector, and Rab14.
AP-3 and Rabip4' coordinately regulate spatial distribution of lysosomes.
van der Sluijs et al., Utrecht, Netherlands. In Plos One, 2011
The RUN and FYVE domain proteins rabip4 and rabip4' are encoded by RUFY1 and differ in a 108 amino acid N-terminal extension in rabip4'.
Functional cross-talk between Rab14 and Rab4 through a dual effector, RUFY1/Rabip4.
GeneRIF
Shin et al., Kyoto, Japan. In Mol Biol Cell, 2010
These findings suggest that Rab14 and Rab4 act sequentially, together with RUFY1.
Membrane insertion of the FYVE domain is modulated by pH.
Kutateladze et al., Aurora, United States. In Proteins, 2009
Lowering the pH enhances the interaction of the Hrs, RUFY1, Vps27p and WDFY1 FYVE domains with PtdIns(3)P-containing membranes in vitro and in vivo, indicating that pH-dependency is a general function of the FYVE finger family.
The Rab4A effector protein Rabip4 is involved in migration of NIH 3T3 fibroblasts.
GeneRIF
Cormont et al., Nice, France. In J Biol Chem, 2006
Rabip4s, possibly via their interaction with Rab4, regulate integrin trafficking and are involved in the migration of NIH 3T3 fibroblasts
The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes.
GeneRIF
Cormont et al., Nice, France. In J Cell Sci, 2006
Rabip4 plays a role in the endocytotic trafficking of Glut4 in 3T3-L1 adipocytes.
Characterization of RUSC1 and RUSC2 genes in silico.
Katoh et al., Narashino, Japan. In Oncol Rep, 2004
RUSC1, RUSC2, RIPX, RUFY1, RUFY2, RUTBC1, RUTBC2, RUTBC3, RUB6IP1, and PLEKHM1 were RUN domain proteins within the human proteome.
Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes.
Pruijn et al., Nijmegen, Netherlands. In Mol Biol Cell, 2004
The 80-kDa protein is a variant of rabip4 with an N-terminal extension of 108 amino acids and is expressed in the same cells.
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