Lipid metabolism in cystic fibrosis.
New York City, United States. In Curr Opin Clin Nutr Metab Care, 2009
Accumulation of free cholesterol in distinct perinuclear compartments, reversible by overexpression of rab9, suggests that cystic fibrosis and the lysosomal storage disease Niemann-Pick-C could share similar cell signaling defects, in addition to increased cAMP signaling and sterol-regulatory element binding protein (SREBP) expression that affect cholesterol metabolism.
Rab GDI: a solubilizing and recycling factor for rab9 protein.
Stanford, United States. In Mol Biol Cell, 1993
We show here that the cytosolic form of rab9, a protein required for transport between late endosomes and the trans Golgi network, also occurs as a complex with a GDI-like protein, with an apparent mass of approximately 80 kD.