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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

RAB7B, member RAS oncogene family

Rab7b
Top mentioned proteins: Rab5, TLR4, Rab7, CAN, Interleukin-6
Papers on Rab7b
Insights into endosomal maturation of human holo-transferrin in the enteric parasite Entamoeba histolytica: essential roles of Rab7A and Rab5 in biogenesis of giant early endocytic vacuoles.
New
Datta et al., Bhopāl, India. In Cell Microbiol, Dec 2015
Here, we carried out a systematic study to understand the role of some of the amoebic homologues of mammalian endocytic Rab GTPases (Rab5 and Rab21, Rab7A and Rab7B) in intracellular transport of human holo-transferrin by the parasite.
Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells.
New
van Die et al., Amsterdam, Netherlands. In Genes Immun, Sep 2015
In addition, T. suis SPs induce Rab7b, a negative regulator of TLR4 signalling that interferes with its trafficking, which coincided with a reduced surface expression of TLR4.
A novel interaction between Rab7b and actomyosin reveals a dual role in intracellular transport and cell migration.
Progida et al., Oslo, Norway. In J Cell Sci, 2014
Here, we show that Rab7b, a Rab that controls the transport between late endosomes and the trans Golgi network, interacts directly with myosin II.
The role of calpain-myosin 9-Rab7b pathway in mediating the expression of Toll-like receptor 4 in platelets: a novel mechanism involved in α-granules trafficking.
Tsai et al., Taipei, Taiwan. In Plos One, 2013
Transmission electron microscope data indicated that human platelets used α-granules to control TLR4 expression; the co-IP experiment suggested that myosin-9 did not coordinate with Rab7b to negatively regulate TLR4 trafficking in thrombin treated platelets.
Identification of a role for the trans-Golgi network in human papillomavirus 16 pseudovirus infection.
Schiller et al., Bethesda, United States. In J Virol, 2013
Additionally, Rab9a and Rab7b were determined to be mediators of this transit, as expression of dominant negative versions of these proteins, but not Rab7a, significantly inhibited HPV16 pseudovirus infection.
Toll-like receptor 4 is not targeted to the lysosome in cystic fibrosis airway epithelial cells.
Schock et al., Belfast, United Kingdom. In Am J Physiol Lung Cell Mol Physiol, 2013
All cells expressed markers of the early (EEA1) and late (Rab7b) endosomes at basal levels.
Dynamics of Rab7b-dependent transport of sorting receptors.
Bakke et al., Oslo, Norway. In Traffic, 2012
The small GTPase Rab7b localizes to late endosomes-lysosomes and to the Golgi, regulating the transport between these two intracellular compartments.
Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies.
Iseki et al., Tokyo, Japan. In J Neuropathol Exp Neurol, 2011
We investigated potential neuropathologic and biochemical alterations of autophagy-lysosome pathway-related proteins in the brains of patients with dementia with Lewy bodies (DLB), Alzheimer disease (AD), and control subjects using antibodies against Ras-related protein Rab-7B (Rab7B), lysosomal-associated membrane protein 2 (LAMP2), and microtubule-associated protein 1A/1B light chain 3 (LC3).
Pulmonary surfactant protein A enhances endolysosomal trafficking in alveolar macrophages through regulation of Rab7.
Stamme et al., Germany. In J Immunol, 2011
In this article, we show that SP-A specifically and transiently enhances the protein expression of endogenous Rab7 and Rab7b, but not Rab5 and Rab11, in primary AM from rats and mice.
Small Rab GTPase Rab7b promotes megakaryocytic differentiation by enhancing IL-6 production and STAT3-GATA-1 association.
GeneRIF
Cai et al., Hangzhou, China. In J Mol Med (berl), 2011
Rab7b may play important roles in megakaryopoiesis by activating NF-kappaB and promoting IL-6 production.
Distinct expression, localization and function of two Rab7 proteins encoded by paralogous genes in a free-living model eukaryote.
Wyroba et al., Warsaw, Poland. In Acta Biochim Pol, 2010
Rab7 GTPases are involved in membrane trafficking in the late endosomal/lysosomal pathway.
Rab7b and receptors trafficking.
Progida et al., Bahrain. In Commun Integr Biol, 2010
Rab7b, believed to have similar function as Rab7, controls however vesicular trafficking from endosomes to the TGN.
Rab7b controls trafficking from endosomes to the TGN.
GeneRIF
Bucci et al., Lecce, Italy. In J Cell Sci, 2010
Rab7b is required for normal lysosome function, and, in particular, it is an essential factor for retrograde transport from endosomes to the trans-Golgi network.
Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease.
Iseki et al., Tokyo, Japan. In J Neuropathol Exp Neurol, 2009
Double immunolabeling demonstrated that these LRRK2-positive granular structures frequently colocalized with the late-endosomal marker Rab7B and occasionally with the lysosomal marker, the lysosomal-associated membrane protein 2. These results suggest that LRRK2 normally localizes to the endosomal-lysosomal compartment within morphologically altered neurons in neurodegenerative diseases, particularly in the brains of patients with LB diseases.
Late endosome/lysosome-localized Rab7b suppresses TLR9-initiated proinflammatory cytokine and type I IFN production in macrophages.
Cao et al., Hangzhou, China. In J Immunol, 2009
Our previous study shows that Rab7b can negatively regulate TLR4 signaling by promoting lysosomal degradation of TLR4.
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