Rab7b and receptors trafficking.
Bahrain. In Commun Integr Biol, 2010
Rab7b, believed to have similar function as Rab7, controls however vesicular trafficking from endosomes to the TGN.
Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease.
Tokyo, Japan. In J Neuropathol Exp Neurol, 2009
Double immunolabeling demonstrated that these LRRK2-positive granular structures frequently colocalized with the late-endosomal marker Rab7B and occasionally with the lysosomal marker, the lysosomal-associated membrane protein 2. These results suggest that LRRK2 normally localizes to the endosomal-lysosomal compartment within morphologically altered neurons in neurodegenerative diseases, particularly in the brains of patients with LB diseases.