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RAB6A, member RAS oncogene family

Rab6, Rab6A
This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: Rab5, YPT1, CAN, ACID, V1a
Papers using Rab6 antibodies
Studying lipids involved in the endosomal pathway.
Supplier
Johannes Ludger, In PLoS ONE, 2011
... We also used polyclonal antibodies made in rabbit against Rab6 (Santa Cruz Biotechnology) and made in sheep ...
SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors
Supplier
Pfeffer Suzanne, In PLoS Biology, 2007
... Polyclonal antibodies made in rabbit against Rab6 were from Santa Cruz Biotechnology and made in sheep ...
Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways
Supplier
Barr Francis A. et al., In The Journal of Cell Biology, 2000
... reagents used were as follows: mouse anti-GM130 and EEA1 (Becton Dickinson), sheep anti-TGN46 (Serotec), rabbit anti-Rab6 (Santa Cruz Biotechnology, Inc.), and Bicaudal-D1 ( ...
A syntaxin 10–SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells
Supplier
Pfeffer Suzanne R. et al., In The Journal of Cell Biology, 2000
... His-Rab6A was purified using Ni-NTA agarose (QIAGEN) and eluted with lysis ...
Active MAP kinase in mitosislocalization at kinetochores and association with the motor protein CENP-E
Supplier
Shapiro Paul et al., In The Journal of Cell Biology, 1997
... Golgi antibodies against p115 and GM130 (BD PharMingen/Transduction Labs) used include Rab6 (Santa Cruz Biotechnology, Inc.), p97 Golgin (Molecular ...
Papers on Rab6
ER trapping reveals Golgi enzymes continually revisit the ER through a recycling pathway that controls Golgi organization.
New
Lippincott-Schwartz et al., Bethesda, United States. In Proc Natl Acad Sci U S A, Jan 2016
Using our trapping scheme, we identify roles of rab6a and calcium-independent phospholipase A2 (iPLA2) in Golgi enzyme recycling, and show that retrograde transport of Golgi membrane underlies Golgi dispersal during microtubule depolymerization and mitosis.
Phenotypic characterisation of RAB6A knockout mouse embryonic fibroblasts.
New
Goud et al., Paris, France. In Biol Cell, Dec 2015
The two ubiquitous Rab isoforms, Rab6A and Rab6A', that are generated by alternative splicing of the RAB6A gene, regulate several transport steps at the Golgi level, including retrograde transport between endosomes and Golgi, anterograde transport between Golgi and the plasma membrane, and intra-Golgi and Golgi to endoplasmic reticulum transport.
Biological Control Activities of Rice-Associated Bacillus sp. Strains against Sheath Blight and Bacterial Panicle Blight of Rice.
New
Ham et al., Chiang Rai, Thailand. In Plos One, Dec 2015
The five selected RABs showing highest antimicrobial activities (RAB6, RAB9, RAB16, RAB17S, and RAB18) were closest to B. amyloliquefaciens in DNA sequence of 16S rDNA and gyrB, but to B. subtilis in that of recA.
Reconstitution of the targeting of Rab6A to the Golgi apparatus in semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on Golgi membranes and a concerted role of Rab6A/BICD2 interactions in Golgi-to-ER retrograde transport.
New
Murata et al., Tokyo, Japan. In Biochim Biophys Acta, Oct 2015
In this study, we reconstituted the Golgi targeting of Rab6A in streptolysin O (SLO)-permeabilized HeLa cells in a cytosol-dependent manner and investigated the biochemical requirements of targeting.
GORAB Missense Mutations Disrupt RAB6 and ARF5 Binding and Golgi Targeting.
New
Kornak et al., Berlin, Germany. In J Invest Dermatol, Oct 2015
The golgin, RAB6-interacting (GORAB) protein localizes to the Golgi apparatus and interacts with the small GTPase RAB6.
The spliceosome factor SART1 exerts its anti-HCV action through mRNA splicing.
New
Chung et al., Boston, United States. In J Hepatol, May 2015
We identified alternative mRNA splicing events for several genes, including EIF4G3, GORASP2, ZFAND6, and RAB6A that contribute to their antiviral effects.
Cohen syndrome-associated protein COH1 physically and functionally interacts with the small GTPase RAB6 at the Golgi complex and directs neurite outgrowth.
New
Haucke et al., Berlin, Germany. In J Biol Chem, Mar 2015
Here, we show that association of COH1 with the Golgi complex depends on the small GTPase RAB6.
Molecular cloning, characterization, and expression of Rab5B, Rab6A, and Rab7 from Litopenaeus vannamei (Penaeidae).
Chen et al., Nanning, China. In Genet Mol Res, 2014
In this study, three Rab family members, Rab5B, Rab6A, and Rab7, designated LvRab5B, LvRab6A, and LvRab7, were cloned from Litopenaeus vannamei.
Dominant spinal muscular atrophy is caused by mutations in BICD2, an important golgin protein.
Review
Wirth et al., Köln, Germany. In Front Neurosci, 2014
BICD2 encodes the Bicaudal D2 protein, which is considered to be a golgin, due to its coiled-coil (CC) structure and interaction with the small GTPase RAB6A located at the Golgi apparatus.
Rab6 regulation of the kinesin family KIF1C motor domain contributes to Golgi tethering.
Pfeffer et al., Stanford, United States. In Elife, 2014
We report here a novel function for KIF1C: it transports Rab6A-vesicles and can influence Golgi complex organization.
Molecular defects in the motor adaptor BICD2 cause proximal spinal muscular atrophy with autosomal-dominant inheritance.
Jordanova et al., Antwerp, Belgium. In Am J Hum Genet, 2013
In addition, the altered protein had a reduced colocalization with RAB6A, a regulator of vesicle trafficking between the Golgi and the endoplasmic reticulum.
C11ORF24 is a novel type I membrane protein that cycles between the Golgi apparatus and the plasma membrane in Rab6-positive vesicles.
Dimitrov et al., Paris, France. In Plos One, 2012
Moreover, via video-microscopy studies we show that C11ORF24 is found on transport intermediates and is colocalized with the small GTPase RAB6, a GTPase involved in anterograde transport from the Golgi to the plasma membrane.
Crystal structure of Rab6A'(Q72L) mutant reveals unexpected GDP/Mg²⁺ binding with opened GTP-binding domain.
GeneRIF
Park et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
the crystal structure of the human Rab6A'(Q72L) mutant form at 1.9A resolution is reported.
Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number.
GeneRIF
Marsh et al., Little Rock, United States. In Traffic, 2012
Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number
Rab6 is a modulator of the unfolded protein response: implications for Alzheimer's disease.
GeneRIF
Scheper et al., Amsterdam, Netherlands. In J Alzheimers Dis, 2011
Rab6 modulates the unfolded protein response (UPR), increased levels inhibit whereas decreased levels augment UPR induction.
Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers.
GeneRIF
Akhmanova et al., Rotterdam, Netherlands. In Curr Biol, 2011
Rab6 is required for Rab8A association with exocytotic vesicles.
Crystallization of an engineered RUN domain of Rab6-interacting protein 1/DENND5.
GeneRIF
Khan et al., Dublin, Ireland. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011
In contrast to wild-type R6IP1-Rab6 crystals, which took several weeks to grow to full size, the engineered R6IP1 (RPdel)-Rab6 crystals could be grown in a matter of days
The localization of the Golgin GCC185 is independent of Rab6A/A' and Arl1.
Impact
GeneRIF
Gleeson et al., Melbourne, Australia. In Cell, 2009
Study demonstrates that Golgi recruitment of endogenous GCC185 does not involve Rab6A/A' and Arl1.
Post-Golgi trafficking of rhodopsin in retinal photoreceptors.
Review
Deretic, Ann Arbor, United States. In Eye (lond), 1997
These studies have revealed an essential role for small GTP-binding protein rab6, as well as the carboxyl-terminal domain of rhodopsin, in the formation of post-Golgi vesicles.
Rab proteins and post-Golgi trafficking of rhodopsin in photoreceptor cells.
Review
Deretic, Ann Arbor, United States. In Electrophoresis, 1997
These studies indicate a succession on rhodopsin-bearing vesicles of rab6, rab11, rab3 and rab8, all members of the small GTP-binding protein family of the known regulators of membrane trafficking.
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