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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

RAB5A, member RAS oncogene family

Rab5, Rab, Rab5a
The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, Rab11, Rab7, ACID
Papers using Rab5 antibodies
A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes
Pal Soumitro, In PLoS ONE, 2008
... to HRP (Santa Cruz Biotechnology, Santa Cruz, CA), anti-Ras (Santa Cruz Biotechnology, Santa Cruz, CA), anti-Rab5 (Santa Cruz Biotechnology, Santa Cruz, CA), anti-AKT ...
Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin.
Ehlers Michael D., In PLoS Biology, 2006
... anti-GluR1 (Calbiochem), mouse anti-HA (Roche), rabbit anti-myc (Upstate Biotechnology), mouse LAMP-1 (Stressgen), mouse anti-myc, rabbit anti-Rab5 (Santa Cruz Biotechnology), rabbit anti-syntaxin 13 (Synaptic ...
The proteasome and its inhibitors in immune regulation and immune disorders
Miaczynska Marta et al., In Experimental Cell Research, 2005
... were used for immunofluorescence: anti-EEA1 and GM130 (BD Transduction Laboratories), CD63 (Developmental Studies Hybridoma Bank), Rab5 (D-11, Santa Cruz Biotechnology), ubiquitin (FK1, Biomol), vimentin ...
Lipid rafts, detergent-resistant membranes, and raft targeting signals
Hueber A-O et al., In Cell Death & Disease, 2005
... Ab-3 in the manuscript), anti-FLAG (M2, Sigma), anti-Fyn (Santa Cruz Biotechnology, Santa Cruz, CA, USA), anti-Rab5 (Santa Cruz Biotechnology) and horseradish peroxidase-conjugated anti-rabbit ...
Static and dynamic errors in particle tracking microrheology.
Delprato Anna Maria, In PLoS ONE, 2004
... Human Rab5 was PCR amplified from a HeLa cDNA library and cloned into eGFP-C1 (Clontech) or mApple ...
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Papers on Rab5
Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.
Yang et al., Beijing, China. In J Cell Biol, Feb 2016
sorf-1 and sorf-2 function coordinately with Rab switching genes to inhibit synthesis of PtdIns3P, allowing its turnover for endosome conversion.
Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease.
Chan et al., San Francisco, United States. In Cell, Feb 2016
The DENN domain is an evolutionary conserved protein module found in all eukaryotes and serves as an exchange factor for Rab-GTPases to regulate diverse cellular functions.
Small GTPases in peroxisome dynamics.
Peränen et al., Heidelberg, Germany. In Biochim Biophys Acta, Feb 2016
A mass spectrometric screen localized various Rab proteins to peroxisomes.
Occupation of nucleotide in the binding pocket is critical to the stability of Rab11A.
Park et al., Seoul, South Korea. In Protein Expr Purif, Feb 2016
Rab GTPases, which belong to the Ras superfamily, are key regulators of intracellular vesicle trafficking via the recruitment of effector molecules.
A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation.
Sherwood et al., Boston, United States. In Plos Genet, Jan 2016
We also characterized a novel invadopodia regulator, gdi-1 (Rab GDP dissociation inhibitor), which mediates membrane trafficking.
SLO BK Potassium Channels Couple Gap Junctions to Inhibition of Calcium Signaling in Olfactory Neuron Diversification.
Chuang et al., Salt Lake City, United States. In Plos Genet, Jan 2016
Furthermore, slo-1 and slo-2 regulate the localization of synaptic markers, UNC-2 and RAB-3, in AWC neurons to control AWC asymmetry.
Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes.
Nakagawa et al., Tokyo, Japan. In Plos One, Dec 2015
Autophagy is a membrane-mediated degradation system that is regulated by intracellular membrane trafficking regulators, including small GTPase Rab proteins.
Rab, Arf and Arl-Regulated Membrane Traffic in Cortical Neuron Migration.
Tang, Singapore, Singapore. In J Cell Physiol, Dec 2015
Rab5 and Rab11, which are key modulators of endocytosis and endocytic recycling respectively, ensure proper surface expression and distribution of N-cadherin, a key adhesion protein that tethers migrating neurons to the radial glia fiber tracts during pia-directed migration.
Identification of an oncogenic RAB protein.
Sawyers et al., New York City, United States. In Science, Nov 2015
In a short hairpin RNA screen for genes that affect AKT phosphorylation, we identified the RAB35 small guanosine triphosphatase (GTPase)-a protein previously implicated in endomembrane trafficking-as a regulator of the phosphatidylinositol 3'-OH kinase (PI3K) pathway.
Gatekeepers Controlling GPCR Export and Function.
Marullo et al., Paris, France. In Trends Pharmacol Sci, Oct 2015
A specific ER-resident gatekeeper, prenylated Rab acceptor family 2 (PRAF2), is involved in GB1 retention and prevents its progression into the biosynthetic pathway.
Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR.
Esteller et al., Barcelona, Spain. In Nat Med, Jul 2015
We found a hypomethylation event that reactivates a cryptic transcript of the Rab GTPase activating protein TBC1D16 (TBC1D16-47 kDa; referred to hereafter as TBC1D16-47KD) to be a characteristic feature of the metastatic cascade.
Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.
Westlake et al., Frederick, United States. In Nat Cell Biol, Mar 2015
How the Rab GTPase Rab11-Rab8 cascade functions in early ciliary membrane assembly is unknown.
Mechanisms and Regulation of the Mitotic Inheritance of the Golgi Complex.
Colanzi et al., Napoli, Italy. In Front Cell Dev Biol, 2014
Most of these events are regulated by small GTPases of the Arf and Rab families.
Defects in the COG complex and COG-related trafficking regulators affect neuronal Golgi function.
Lupashin et al., Little Rock, United States. In Front Neurosci, 2014
The essential function of the COG complex is dependent upon interactions with other components of trafficking machinery, such as Rab-GTPases and SNAREs.
ER contact sites define the position and timing of endosome fission.
Voeltz et al., Boulder, United States. In Cell, 2014
Endocytic cargo and Rab GTPases are segregated to distinct domains of an endosome.
Acidosis-induced V-ATPase trafficking in salivary ducts is initiated by cAMP/PKA/CREB pathway via regulation of Rab11b expression.
Roussa et al., Freiburg, Germany. In Int J Biochem Cell Biol, 2012
Data show that the cAMP/PKA/CREB signaling pathway initiates acidosis-induced V-ATPase trafficking in salivary ducts via regulation of Rab11b expression.
Planar cell polarity controls directional Notch signaling in the Drosophila leg.
Galindo et al., Valencia, Spain. In Development, 2012
increased Rab5 levels or dominant-negative Deltex can suppress the ectopic joints.
Rab5 proteins regulate activation and localization of target of rapamycin complex 1.
Saltiel et al., Ann Arbor, United States. In J Biol Chem, 2012
regulation of PI(3)P synthesis by Rab5 and Vps21 is essential for TORC1 function in both contexts.
RBE controls microRNA164 expression to effect floral organogenesis.
Irish et al., New Haven, United States. In Development, 2012
These results indicate that one role of RBE is to fine-tune miR164 expression to regulate the CUC1 and CUC2 effector genes, which, in turn, regulate developmental events required for sepal and petal organogenesis.
Yersinia entry into host cells requires Rab5-dependent dephosphorylation of PI(4,5)P₂ and membrane scission.
Grinstein et al., Toronto, Canada. In Cell Host Microbe, 2012
Recruitment of the inositol 5-phosphatases OCRL and Inpp5b to the Yersinia-filled prevacuoles and subsequent phosphatidylinositol 4,5-diphosphate hydrolysis required the association of the GTPase Rab5 with prevacuoles.
More papers using Rab5 antibodies
Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells.
Bereswill Stefan, In PLoS ONE, 2001
... Rab 5 antibody was purchased from Cell Signaling Technology and Rab 9 antibody ...
Protein lipid overlay assay.
Delprato Anna Maria, In PLoS ONE, 2001
... Polyclonal rabbit anti-human Rab5a antibody was from Cell Signaling.
Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway
van der Goot F. Gisou et al., In The Journal of Cell Biology, 2000
... terminus of MKK3, EF-2, and rab5 was purchased from Santa Cruz Biotechnology Inc.; and rab7, ɛ-COP, ...
Disruption of two novel genes by a translocation co-segregating with schizophrenia.
Aguilar Ruben Claudio, In PLoS ONE, 1999
... Louis, Missouri), anti-Rab5 monoclonal (Santa Cruz Biotechnology, Santa Cruz, CA), anti-VSV ...
Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells
Zerial Marino et al., In The Journal of Cell Biology, 1997
... Rab proteins were fused COOH-terminally to GFP using the pEGFP-C3, pECFP-C3, or pEYFP-C3 vectors provided by CLONTECH Laboratories, Inc ...
Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release
González-Gaitán Marcos et al., In The Journal of Cell Biology, 1989
... In UAS-GFP-Rab5, EGFP (CLONTECH Laboratories, Inc.) was cloned ...
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