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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

RAB4A, member RAS oncogene family

Rab4, Rab4a
may play a role in intracellular recruitment of the glucose transporter GLUT4 [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Rab5, Transferrin, Rab11, V1a, YPT1
Papers using Rab4 antibodies
Anti-apoptotic activity of Bcl-2 is enhanced by its interaction with RTN3.
Supplier
Linden Rafael, In PLoS ONE, 2006
... directed against PARP, Cytochrome c (7H8.2C12) and polyclonal against Bcl-xL were from BD Biosciences, polyclonal against Rab4 was from Abcam, was from Sigma, monoclonal ...
Dual specificity of the interfacial inhibitor brefeldin a for arf proteins and sec7 domains.
Supplier
Caplan Steve H., In PLoS ONE, 2005
... anti-CIMPR (BioLegend), mouse anti-β1 integrin (P5D2, Hybridoma Bank), mouse anti-activated β1 integrin (HUTS-21, BD), rabbit anti-Rab4 (Abcam), and rabbit anti-Rab11 (Invitrogen) ...
Neural cell adhesion molecule promotes accumulation of TGN organelles at sites of neuron-to-neuron contacts
Supplier
Schachner Melitta et al., In The Journal of Cell Biology, 2000
... also used mouse monoclonal antibodies against γ-adaptin and EEA1 (Transduction Laboratories), rabbit polyclonal antibodies against Rab4 and goat polyclonal antibodies against βI spectrin (Santa Cruz Biotechnology, Inc.), rat monoclonal antibody ...
Analysis of amino and carboxy terminal GLUT-4 targeting motifs in 3T3-L1 adipocytes using an endosomal ablation technique.
Supplier
Calbet Jose A. L., In PLoS ONE, 1998
... Anti Rab4 mAb was from BD Biosciences Pharmingen (San Diego, CA, ...
Papers on Rab4
Intracellular periodontal pathogen exploits recycling pathway to exit from infected cells.
New
Amano et al., Suita, Japan. In Cell Microbiol, Dec 2015
In the present study, we found that the pathogen localized in early endosomes recruits VAMP2 and Rab4A.
Elevated temperature inhibits recruitment of transferrin-positive vesicles and induces iron-deficiency genes expression in Aiptasia pulchella host-harbored Symbiodinium.
New
Chen et al., Kao-hsiung, Taiwan. In Comp Biochem Physiol B Biochem Mol Biol, Oct 2015
Since cellular iron acquisition is known to be mediated through transferrin receptor-mediated endocytosis, a vesicular trafficking pathway specifically regulated by Rab4 and Rab5, we set out to examine the roles of these key proteins in the iron acquisition by the symbiotic Symbiodinium.
Angiotensin II stimulates internalization and degradation of arterial myocyte plasma membrane BK channels to induce vasoconstriction.
New
Jaggar et al., Memphis, United States. In Am J Physiol Cell Physiol, Oct 2015
Here, using biotinylation, immunofluorescence resonance energy transfer (immunoFRET) microscopy, and RNAi-mediated knockdown, we demonstrate that rab4A-positive early endosomes traffic BKα to the plasma membrane in myocytes of resistance-size cerebral arteries.
Inhibitory effects of proton beam irradiation on integrin expression and signaling pathway in human colon carcinoma HT29 cells.
Shon et al., Taegu, South Korea. In Int J Oncol, 2014
Simultaneously, the gene expression of cell adhesion molecules, such as FAK and CDH1, and integrin trafficking regulators, such as RAB4, RAB11, and HAX1, was decreased by proton beam irradiation.
Methods for analysis of AP-3/Rabin4' in regulation of lysosome distribution.
van der Sluijs et al., Bucureşti, Romania. In Methods Mol Biol, 2014
We recently found that the rab5 and rab4 effector rabip4' interacts with the adaptor complex AP-3 in a rab4-dependent manner on tubular endosomes.
HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE.
Perl et al., Syracuse, United States. In Ann Rheum Dis, 2014
T cells of 4-week-old MRL/lpr mice exhibited 4.7-fold over-expression of Rab4A (p=0.0002), the murine homologue of HRES-1/Rab4, and depletion of Drp1 that preceded the accumulation of mitochondria, ANA production and nephritis.
A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination.
Scita et al., Milano, Italy. In J Cell Biol, 2014
RAB5A promotes RAB4- and RABENOSYN-5-dependent endo/exocytic cycles (EECs) of critical cargos (membrane-type 1 matrix metalloprotease [MT1-MMP] and β3 integrin) required for invadosome formation in response to motogenic stimuli.
Rab10 delivers GLUT4 storage vesicles to the plasma membrane.
Lippincott-Schwartz et al., Bethesda, United States. In Commun Integr Biol, 2013
Several other Rab proteins, including Rab4A, 4B and 8A, were found to mediate GLUT4 intra-endosomal recycling, serving to internalize surface-bound GLUT4 into endosomal compartments for ultimate delivery to GSVs.
Assessment of pelvic floor by three-dimensional-ultrasound in primiparous women according to delivery mode: initial experience from a single reference service in Brazil.
Moron et al., São Paulo, Brazil. In Rev Bras Ginecol Obstet, 2013
A convex volumetric transducer (RAB4-8L) was used, in contact with the large labia, with the patient in the gynecological position.
Rab GTPases regulate endothelial cell protein C receptor-mediated endocytosis and trafficking of factor VIIa.
Rao et al., Tyler, United States. In Plos One, 2012
In cells expressing wild-type or constitutively active Rab4A, internalized AF488-FVIIa accumulated in early/sorting endosomes and its entry into the recycling endosomal compartment (REC) was inhibited.
Rab4 and Rab5 GTPase are required for directional mobility of endocytic vesicles in astrocytes.
GeneRIF
Zorec et al., Ljubljana, Slovenia. In Glia, 2012
The reduction of vesicles exhibiting directional mobility induced by Rab4 mutants indicates that GTP-GDP switching is required for maintaining directional mobility.
Desensitization, trafficking, and resensitization of the pituitary thyrotropin-releasing hormone receptor.
Jones et al., Rochester, United States. In Front Neurosci, 2011
Over approximately 20 min these form larger endosomes rich in rab4 and rab5, early sorting endosomes.
Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease.
GeneRIF
Che et al., United States. In J Chem Neuroanat, 2011
Upregulated expression of rab4, rab5, rab7 and rab27 correlates with antemortem measures of cognitive decline in individuals with mild cognitive impairment and Alzheimer disease.
Procathepsin L secretion, which triggers tumour progression, is regulated by Rab4a in human melanoma cells.
GeneRIF
Frade et al., Rouen, France. In Biochem J, 2011
Thus down- or up-regulation of Rab4A expression or Rab4A function triggered inhibition or increase of procathepsin L secretion respectively.
Rab GTPases bind at a common site within the angiotensin II type I receptor carboxyl-terminal tail: evidence that Rab4 regulates receptor phosphorylation, desensitization, and resensitization.
GeneRIF
Ferguson et al., London, Canada. In Mol Pharmacol, 2011
Overexpression of Rab4 regulates angiotensin II type I receptor phosphorylation and sensitization.
Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity.
GeneRIF
Muslin et al., Saint Louis, United States. In J Mol Cell Cardiol, 2010
Reduced Akt2 leads to up-regulation of Rab4a expression in cardiomyocytes in a cell-autonomous fashion that may involve activation of PPARalpha.
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Impact
Carninci et al., Wako, Japan. In Nat Methods, 2004
These genes include those encoding important regulatory factors such as cyclin D2, Ilk, MAPK12, MAPK14, RAB4, melastatin 1 and previously unidentified splicing events for 436 genes.
Regulation of membrane transport through the endocytic pathway by rabGTPases.
Review
van der Sluijs et al., Utrecht, Netherlands. In Mol Membr Biol, 1999
Several of them, including rab5, rab4 and rab11, are localized to early endocytic organelles where they regulate distinct events in the transferrin receptor pathway.
[Transcytosis of immunoglobulin IgG].
Review
Ichimura, Yamaguchi, Japan. In Kaibogaku Zasshi, 1998
Small GTP-binding proteins rab4 and/or rab5A are immunohistochemically localized on recycling and/or sorting endosomes, suggesting their involvement in forming vesicles transporting the IgG-FcR complex.
The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway.
Impact
Mellman et al., New Haven, United States. In Cell, 1992
rab4 is a ras-like GTP-binding protein that associates with early endosomes in a cell cycle-dependent fashion.
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