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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

RAB3A, member RAS oncogene family

Rab3A, rab3
regulated synaptic vesicle endocytosis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Rab5, CAN, ACID, HAD, SNAP-25
Papers using Rab3A antibodies
Docking of secretory vesicles is syntaxin dependent.
Supplier
Lu Bai, In PLoS ONE, 2005
... Rab3a constructs were cloned into pIRES2-EGFP vector (Clontech, USA) and Rab3a-IRES-EGFP was ...
Distinction between true acrosome reaction and degenerative acrosome loss by a one-step staining method using Pisum sativum agglutinin
Supplier
Hughson Fred, In PLoS Biology, 1991
... Anti-Rab3A (rabbit polyclonal, purified IgG) was from Santa Cruz Biotechnology (Santa Cruz, California, United ...
Papers on Rab3A
Effects of simulated microgravity on the expression of presynaptic proteins distorting the GABA/glutamate equilibrium - A proteomics approach.
New
Deng et al., Beijing, China. In Proteomics, Nov 2015
Synaptic vesicle recycling may also be affected due to the dysregulation of syntaxin-binding protein 5 (tomosyn), rab3A and its effector rim2.
ADP ribosylation factor 6 (ARF6) promotes acrosomal exocytosis by modulating lipid turnover and Rab3A activation.
New
Belmonte et al., Strasbourg, France. In J Biol Chem, May 2015
We show that active ARF6 increases the exchange of GDP for GTP on Rab3A, a prerequisite for secretion.
Bruchpilot and Synaptotagmin collaborate to drive rapid glutamate release and active zone differentiation.
Heckmann et al., Würzburg, Germany. In Front Cell Neurosci, 2014
To test the mechanism of release protraction at brp(69) AZs, we performed knock-down of Synaptotagmin-1 (Syt) via RNAi (syt(KD) ) in wildtype (wt), brp(69) and rab3 null mutants (rab3(rup) ), where Brp is concentrated at a small number of AZs.
Reduced gene expression levels of Munc13-1 and additional components of the presynaptic exocytosis machinery upon conditional targeting of Vglut2 in the adolescent mouse.
Wallén-Mackenzie et al., Uppsala, Sweden. In Synapse, 2014
Genes encoding additional components of the presynaptic machinery were also found regulated, including Rab3A, RIM1α, as well as Syntaxin1 and Synaptobrevin.
Exocytosis and synaptic vesicle function.
Review
Shin, Galveston, United States. In Compr Physiol, 2014
In addition, at least five different types of synaptic vesicle proteins such as synaptic vesicle protein 2, cysteine string protein α, rab3, synapsin, and a group of proteins containing four transmembrane regions, which includes synaptophysin, synaptogyrin, and secretory carrier membrane protein, are involved in modulating the exocytotic process by regulating the formation and trafficking of synaptic vesicles.
Large homozygous RAB3GAP1 gene microdeletion causes Warburg micro syndrome 1.
Kaindl et al., In Orphanet J Rare Dis, 2013
WARBM1-4 can be caused by biallelic mutations of the RAB3GAP1 (RAB3 GTPase-activating protein 1), RAB3GAP2, RAB18 (RAS-associated protein RAB18), or TBC1D20 (TBC1 domain protein, member 20) gene, respectively.
RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy.
Behl et al., Mainz, Germany. In Autophagy, 2013
Significant levels of RAB3GAP1/2 colocalize with members of the Atg8 family at lipid droplets, and their autophagy modulatory activity depends on the GTPase-activating activity of RAB3GAP1 but is independent of the RAB GTPase RAB3.
Decreased expression of synapse-related genes and loss of synapses in major depressive disorder.
Impact
Duman et al., New Haven, United States. In Nat Med, 2012
Here we use microarray gene profiling and electron microscopic stereology to reveal lower expression of synaptic-function–related genes (CALM2, SYN1, RAB3A, RAB4B and TUBB4) in the dlPFC of subjects with MDD and a corresponding lower number of synapses.
Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis.
GeneRIF
Tomes et al., Mendoza, Argentina. In Proc Natl Acad Sci U S A, 2012
Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis.
Rab3A mediates vesicle delivery at photoreceptor ribbon synapses.
GeneRIF
Kramer et al., Berkeley, United States. In J Neurosci, 2012
these findings suggest a crucial role of Rab3A in delivering vesicles to Ca2+ -dependent release sites at ribbon synapses.
Proteinuria and glomerular damage in Rab3A knockout mice chronically fed a high-glucose diet.
GeneRIF
Rastaldi et al., Milano, Italy. In Nephron Exp Nephrol, 2011
Data show diminished actin plasticity in the cell processes of Rab3A knockout (KO) podocytes.
Involvement of Rab3A in vesicle priming during exocytosis: interaction with Munc13-1 and Munc18-1.
GeneRIF
Kao et al., Taipei, Taiwan. In Traffic, 2011
the Rab3A cycle is coupled with the activation of Munc13-1 via RIM, which accounts for the regulation of secretion by Rab3A.
Impaired activity-dependent plasticity of quantal amplitude at the neuromuscular junction of Rab3A deletion and Rab3A earlybird mutant mice.
GeneRIF
Engisch et al., Dayton, United States. In J Neurosci, 2011
We conclude that Rab3A is involved in a novel presynaptic mechanism to homeostatically regulate the amount of transmitter in a quantum.
Rim2alpha determines docking and priming states in insulin granule exocytosis.
Impact
Seino et al., Kōbe, Japan. In Cell Metab, 2010
We found that interaction of Rim2alpha and Rab3A is required for docking, which is considered a brake on fusion events, and that docking is necessary for K(+)-induced exocytosis, but not for glucose-induced exocytosis.
Metallothioneins and cancer.
Review
Kizek et al., Brno, Czech Republic. In Curr Protein Pept Sci, 2009
p53, NF-kappaB, PKCl, and GTPase Rab3A.
Core proteins of the secretory machinery.
Review
Jahn et al., Göttingen, Germany. In Handb Exp Pharmacol, 2007
Exocytosis of synaptic vesicles and regulated secretory granules are among the best-studied fusion events and involve the Rab3 isoforms Rab3A-D, the SM protein munc18-1, and the SNAREs syntaxin 1A, SNAP-25, and synaptobrevin 2. According to the current view, syntaxin 1A and SNAP-25 at the presynaptic membrane form a complex with synaptic vesicle-associated synaptobrevin 2. As complex formation proceeds, the opposed membranes are pulled tightly together, enforcing the fusion reaction.
SNAREing voltage-gated K+ and ATP-sensitive K+ channels: tuning beta-cell excitability with syntaxin-1A and other exocytotic proteins.
Review
Impact
Gaisano et al., Taiwan. In Endocr Rev, 2007
Other proteins involved in exocytosis, such as Munc-13, tomosyn, rab3a-interacting molecule, and guanyl nucleotide exchange factor II, have also been implicated in direct or indirect regulation of beta-cell ion channel activities and excitability.
Acrosomal exocytosis, a special type of regulated secretion.
Review
Belmonte et al., Mendoza, Argentina. In Iubmb Life, 2007
Sperm activation causes a calcium increase in the cytoplasm that promotes the production of cAMP and activates Rab3A.
Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome.
Impact
Maher et al., Birmingham, United Kingdom. In Nat Genet, 2005
We identified homozygous inactivating mutations in RAB3GAP, encoding RAB3 GTPase activating protein, a key regulator of the Rab3 pathway implicated in exocytic release of neurotransmitters and hormones, in 12 families with Micro syndrome.
RIM1alpha is required for presynaptic long-term potentiation.
Impact
Malenka et al., Stanford, United States. In Nature, 2002
Studies of knockout mice have shown that the synaptic vesicle protein Rab3A is required for mossy fibre LTP, but the protein kinase A substrates rabphilin, synapsin I and synapsin II are dispensable.
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