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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

RAB25, member RAS oncogene family

Rab25
RAB proteins, such as RAB25, are members of the RAS superfamily of small GTPases that are involved in membrane trafficking. Members of the RAB11 subfamily, including RAB25, control the return of internalized membrane-associated moieties to the cell surface (Caswell et al., 2007 [PubMed 17925226]).[supplied by OMIM, Aug 2009] (from NCBI)
Top mentioned proteins: Rab5, Rab11, HAD, CAN, Rab3A
Papers on Rab25
Overexpression of Rab25 promotes hepatocellular carcinoma cell proliferation and invasion.
New
Liu et al., Shenyang, China. In Tumour Biol, Jan 2016
UNASSIGNED: Rab25 was reported to be associated with several human cancers and malignant biological behavior of cancer cells.
Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer.
New
Watanabe et al., Japan. In Oncotarget, Jan 2016
CRL and MDAMB453 cells were identified as PB-sensitive, while MDAMB231 cells were PB-resistant.RAB25 and ESRP1 were identified as key regulators of PB sensitivity, while ANKD1, ETS1, PTRF, IFI16 and KIAA1199 acted as PB resistance-related genes.
Neisseria meningitidis subverts the polarized organization and intracellular trafficking of host cells to cross the epithelial barrier.
New
Aricò et al., Siena, Italy. In Cell Microbiol, Sep 2015
Additionally, the association of N. meningitidis with different endosomal compartments was evaluated through the concomitant staining of bacteria and markers specific for Rab11, Rab22a, Rab25 and Rab3 followed by confocal microscopy imaging.
Downregulation of Rab25 activates Akt1 in head and neck squamous cell carcinoma.
New
Buyru et al., İstanbul, Turkey. In Oncol Lett, Sep 2015
UNASSIGNED: Several studies have suggested that Ras-associated binding 25 protein (Rab25) is involved in the pathogenesis of human cancer.
Structure-Function Analyses of the Interactions between Rab11 and Rab14 Small GTPases with Their Shared Effector Rab Coupling Protein (RCP).
New
Khan et al., Cork, Ireland. In J Biol Chem, Aug 2015
Rab11 and Rab25 are closely related small GTPases that bind to common effectors termed the Rab11 family of interacting proteins (FIPs).
CCN3 overexpression inhibits growth of callosal projections via upregulation of RAB25.
New
Shim et al., Seoul, South Korea. In Biochem Biophys Res Commun, Jul 2015
Moreover, we identified the small GTPase RAB25 as a downstream effector molecule of CCN3 using transcriptomic analysis with CCN3 overexpressed in cortical tissue.
The role of the small GTPase Rab31 in cancer.
Review
Tang et al., Singapore, Singapore. In J Cell Mol Med, 2015
A good number of Rabs have been implicated or associated with various human cancers, and much recent excitement has been associated with the roles of the Rab11 subfamily member Rab25 and its effector, the Rab coupling protein (RCP), in tumourigenesis and metastasis.
Characterization of the role Rab25 in energy metabolism and cancer using extracellular flux analysis and material balance.
Dennison et al., Houston, United States. In Methods Mol Biol, 2014
Rab25, by altering trafficking of critical cellular resources, influences cell metabolism and survival during stress conditions.
Rab11 in disease progression.
Review
Roy et al., Barddhamān, India. In Int J Mol Cell Med, 2014
Three members: Rab11a, Rab11b and Rab25 make up the Rab11 GTPase subfamily.
Expression of Ras-related protein 25 predicts chemotherapy resistance and prognosis in advanced non-small cell lung cancer.
Liu et al., Beijing, China. In Genet Mol Res, 2014
Ras-related protein 25 (Rab25) is involved in many human malignancies.
Cucurbit [7] uril encapsulated cisplatin overcomes resistance to cisplatin induced by Rab25 overexpression in an intraperitoneal ovarian cancer model.
Plumb et al., Sydney, Australia. In J Ovarian Res, 2014
METHODS: Longitudinal studies comparing cisplatin performance either alone or in a novel cisplatin-based delivery-system, cucurbit[7]uril-encapsulated cisplatin (cisplatin@CB[7]) were performed on subcutaneous (s.c.) and intraperitoneal (i.p.) xenografts using the human ovarian cancer cell line A2780 stably expressing the small GTPase Rab25, which allows A2780 intraperitoneal growth; and luciferase, to allow tumour load measurement by non-invasive bioluminescent imaging.
Orchestration of cell surface proteins by Rab11.
Review
Kerkhoff et al., Regensburg, Germany. In Trends Cell Biol, 2014
The Rab11 small G proteins (Rab11a, b, and Rab25) of the Ras superfamily are master regulators of the surface expression of receptors and adhesion proteins.
Regulation of autophagy by the Rab GTPase network.
Review
Wu et al., Chongqing, China. In Cell Death Differ, 2014
Rab8A and Rab25 are also involved in autophagy, but their role is unknown.
Rab25 in cancer: a brief update.
Review
Mills et al., Houston, United States. In Biochem Soc Trans, 2013
Rab25 is an epithelial-cell-specific member of the Rab GTPase superfamily, sharing close homology with Rab11a, the endosomal recycling Rab GTPase.
Rab25 is overexpressed in Müllerian serous carcinoma compared to malignant mesothelioma.
GeneRIF
Davidson et al., Oslo, Norway. In Virchows Arch, 2012
Rab25 effectively differentiates Mullerian carcinomas from malignant mesothelioma
Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress.
GeneRIF
Mills et al., Houston, United States. In Embo Mol Med, 2012
Rab25 induced the accumulation of glycogen in epithelial cancer cells, a process not previously identified. (RAB25)
The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration.
GeneRIF
Jendrossek et al., Essen, Germany. In Cell Physiol Biochem, 2011
Rab25 acts predominantly in the small-scale fast recycling within the tips of the cell. Our results further support the idea of Rab25 as a promoter of tumor development
A CRE that binds CREB and contributes to PKA-dependent regulation of the proximal promoter of human RAB25 gene.
GeneRIF
Huang et al., Shanghai, China. In Int J Biochem Cell Biol, 2011
The present study delineates the fundamental elements of a core promoter structure that will be helpful for future studies regarding the regulation of RAB25 gene.
Transformation of rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent.
GeneRIF
Goldenring et al., Nashville, United States. In Cytoskeleton (hoboken), 2011
up-regulation of Rab25 in RIE cells leads to microtubule-dependent transformation. Thus, depolymerization of microtubules may be a potent therapeutic target for cancer therapy through the reversal of the invasive phenotype of certain cancer cells.
The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers.
Impact
Mills et al., Houston, United States. In Nat Med, 2004
High-density array comparative genomic hybridization (CGH) showed amplification of chromosome 1q22 centered on the RAB25 small GTPase, which is implicated in apical vesicle trafficking, in approximately half of ovarian and breast cancers.
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