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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

RAB21, member RAS oncogene family

Rab21
RAB21 belongs to the RAB family of small GTP-binding proteins that regulate intracellular vesicle targeting (Opdam et al., 2000 [PubMed 10887961]).[supplied by OMIM, Nov 2008] (from NCBI)
Top mentioned proteins: Rab5, ACID, miR, Rab23, RAB18
Papers using Rab21 antibodies
Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5
Supplier
Ivaska Johanna et al., In The Journal of Cell Biology, 2006
... Commercial antibodies against the following antigens were used: Rab21 (Abnova), β1-integrin (P5D2, P4G11, and ...
Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of β1-integrins
Supplier
Ivaska Johanna et al., In The Journal of Cell Biology, 2003
... Full-length Rab21 was subcloned from Rab21 murine cDNA (clone 6490069; IMAGE) by PCR amplification and ligated into pRluc-C2 (PerkinElmer) and in pEGFP-C2 (CLONTECH ...
Papers on Rab21
Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion.
New
Kiger et al., San Diego, United States. In Embo Rep, Mar 2015
We previously identified Drosophila Sbf as a Rab21 guanine nucleotide exchange factor (GEF) that acts with Rab21 in endosomal trafficking.
Proteomics profiling identify CAPS as a potential predictive marker of tamoxifen resistance in estrogen receptor positive breast cancer.
Linderholm et al., Stockholm, Sweden. In Clin Proteomics, 2014
A panel of 13 proteins (TCEAL4, AZGP1, S100A10, ALDH6A1, AHNAK, FBP1, S100A4, HSP90AB1, PDXK, GFPT1, RAB21, MX1, CAPS) from the 3101 identified proteins, potentially separate relapse from non-relapse BC patients.
miR-200b as a prognostic factor targets multiple members of RAB family in glioma.
Jiang et al., Changsha, China. In Med Oncol, 2014
Members of RAB family, RAB21, RAB23, RAB18 and RAB3B were predicted to be novel targets of miR-200b.
miR-200b as a prognostic factor in breast cancer targets multiple members of RAB family.
Xie et al., Guangzhou, China. In J Transl Med, 2013
Members of RAB family, RAB21, RAB23, RAB18 and RAB3B were predicted to be the targets of miR-200b.
MiR-183/-96/-182 cluster is up-regulated in most breast cancers and increases cell proliferation and migration.
Zhu et al., In Breast Cancer Res, 2013
MiR-183 targeted the RAB21 mRNA directly in breast cancer.
Overexpression of OsMYB48-1, a novel MYB-related transcription factor, enhances drought and salinity tolerance in rice.
Li et al., Beijing, China. In Plos One, 2013
Further studies demonstrated that overexpression of OsMYB48-1 could regulate the expression of some ABA biosynthesis genes (OsNCED4, OsNCED5), early signaling genes (OsPP2C68, OSRK1) and late responsive genes (RAB21, OsLEA3, RAB16C and RAB16D) under drought stress conditions.
Rab21 attenuates EGF-mediated MAPK signaling through enhancing EGFR internalization and degradation.
GeneRIF
Chang et al., Beijing, China. In Biochem Biophys Res Commun, 2012
Taken together, these data suggest that Rab21 plays a negative role in the EGF-mediated MAPK signaling pathway. Overexpression of Rab21 attenuated EGF-mediated mitogen-activated protein kinase (MAPK) signaling by inducing EGFR degradation.
Endosomal trafficking of the G protein-coupled receptor somatostatin receptor 3.
GeneRIF
Sztul et al., Birmingham, United States. In Biochem Biophys Res Commun, 2011
this novel finding that Rab21 regulates SSTR3 trafficking suggests that Rab21 may play a role in trafficking of other GPCRs.
Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration.
GeneRIF
Ivaska et al., Turku, Finland. In J Cell Biol, 2011
Mechanistically, p120RasGAP interacted with the cytoplasmic domain of integrin alpha-subunits via its GAP domain and competed with Rab21 for binding to endocytosed integrins.
Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth.
GeneRIF
Galli et al., Paris, France. In Embo Rep, 2009
show that TI-VAMP interacts with the Vps9 domain and ankyrin-repeat-containing protein Varp, a guanine nucleotide exchange factor of the small GTPase Rab21, through a specific domain herein called the interacting domain.
Dynamic changes in the spatiotemporal localization of Rab21 in live RAW264 cells during macropinocytosis.
GeneRIF
Araki et al., Japan. In Plos One, 2008
data indicate that Rab21 is a transient component of early and intermediate stages of macropinocytosis, and probably functions in macropinosome maturation before fusing with lysosomal compartments
The Arabidopsis AtNPR1 inversely modulates defense responses against fungal, bacterial, or viral pathogens while conferring hypersensitivity to abiotic stresses in transgenic rice.
San Segundo et al., Barcelona, Spain. In Mol Plant Microbe Interact, 2008
Moreover, AtNPR1 negatively regulates the expression of genes playing a role in the plant response to salt and drought stress (rab21, salT, and dip1), which results in a higher sensitivity of AtNPR1 rice to the two types of abiotic stress.
Structural basis for Rab GTPase activation by VPS9 domain exchange factors.
Lambright et al., Worcester, United States. In Nat Struct Mol Biol, 2007
RABEX-5 and other exchange factors with VPS9 domains regulate endocytic trafficking through activation of the Rab family GTPases RAB5, RAB21 and RAB22.
Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias.
Impact
Sikic et al., Stanford, United States. In J Clin Oncol, 2007
This set of 271 differentially expressed genes (including GAB1, CIITA, XBP1, CD83, SERPINB9, PTP4A3, NOV, LOX, CTNND1, BAALC, and RAB21) is enriched for genes involved in cell death, cellular growth and proliferation, and hematologic system development and function.
A tomato cDNA inducible by salt stress and abscisic acid: nucleotide sequence and expression pattern.
Pintor-Toro et al., Sevilla, Spain. In Plant Mol Biol, 1990
The sequence of the predicted TAS14 protein shows four structural domains similar to the rice RAB21, cotton LEA D11 and barley and maize dehydrin genes.
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