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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

RAB1B, member RAS oncogene family

Rab1B, small GTP-binding protein
Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM, Jan 2009] (from NCBI)
Top mentioned proteins: Rhodopsin, Actin, ACID, Rab5, RhoA
Papers on Rab1B
Arf6 controls platelet spreading and clot retraction via integrin αIIbβ3 trafficking.
Whiteheart et al., Lexington, United States. In Blood, Feb 2016
ADP-ribosylation factor 6 (Arf6) is a small GTP-binding protein known to regulate endocytic trafficking, especially of integrins.
Statins up-regulate SmgGDS through β1-integrin/Akt1 pathway in endothelial cells.
Shimokawa et al., Asahi, Japan. In Cardiovasc Res, Feb 2016
We have recently demonstrated that the pleiotropic effects of statins are partly mediated through up-regulation of small GTP-binding protein dissociation stimulator (SmgGDS) with a resultant Rac1 degradation and reduced oxidative stress.
Genetic deletion of Rhes or pharmacological blockade of mTORC1 prevent striato-nigral neurons activation in levodopa-induced dyskinesia.
Morari et al., Ferrara, Italy. In Neurobiol Dis, Jan 2016
Ras homolog enriched in striatum (Rhes) is a small GTP-binding protein that modulates signal transduction at dopamine receptors, and also activates mammalian target of rapamycin complex 1 (mTORC1).
Rho Kinase and Dopaminergic Degeneration: A Promising Therapeutic Target for Parkinson's Disease.
Guerra et al., Santiago de Compostela, Spain. In Neuroscientist, Dec 2015
The small GTP-binding protein Rho plays an important role in several cellular functions.
JAK2 tyrosine kinase mediates integrin activation induced by CXCL12 in B-cell chronic lymphocytic leukemia.
Laudanna et al., Verona, Italy. In Oncotarget, Nov 2015
We also show that JAK2 mediates the activation of the small GTP-binding protein RhoA, in turn controlling LFA-1 affinity triggering by CXCL12.
Lysine-acetylation as a fundamental regulator of Ran function: Implications for signaling of proteins of the Ras-superfamily.
Lammers et al., Köln, Germany. In Small Gtpases, Nov 2015
UNASSIGNED: The small GTP-binding protein Ran is involved in the regulation of essential cellular processes in interphase but also in mitotic cells: Ran controls the nucleocytoplasmic transport of proteins and RNA, it regulates mitotic spindle formation and nuclear envelope assembly.
2015 ATVB Plenary Lecture: translational research on rho-kinase in cardiovascular medicine.
Satoh et al., Sendai, Japan. In Arterioscler Thromb Vasc Biol, Aug 2015
Rho-kinase (ROCKs) is an important downstream effector of the small GTP-binding protein Ras homolog gene family member A. There are 2 isoforms of ROCK, ROCK1 and ROCK2, and they have different functions in several vascular components.
Modulation of actin dynamics by Rac1 to target cognitive function.
Tejada-Simon, Houston, United States. In J Neurochem, Jun 2015
Less research, however, has been done regarding the role of this small GTP-binding protein in brain development, where it has an important role in dendritic spine morphogenesis through the regulation of actin.
Regulation of bone and skeletal development by the SHP-2 protein tyrosine phosphatase.
King et al., Dallas, United States. In Bone, 2014
Src homology-2 protein tyrosine phosphatase (SHP-2) that is encoded by the PTPN11 gene in humans is an intracellular signaling molecule that couples growth factor receptors to activation of the Ras small GTP-binding protein that regulates cell growth, proliferation and differentiation.
The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport.
Simpson et al., Dublin, Ireland. In Biochem Soc Trans, 2014
At least two mechanisms of transport move material in the retrograde direction: one regulated by the cytoplasmic coatomer protein I complex (COPI), and a second COPI-independent pathway utilizing the small GTP-binding protein Rab6.
Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway.
Pepperkok et al., Dublin, Ireland. In Nat Cell Biol, 2012
Network analyses revealed a so far unappreciated link between early secretory pathway function, small GTP-binding protein regulation, actin cytoskeleton organization and EGF-receptor-mediated signalling.
Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopment.
Crump et al., Cambridge, United Kingdom. In J Virol, 2011
Rab1a/b and Rab43, are important for herpes simplex virus 1 virion assembly
Role of Rab1b in COPII dynamics and function.
Alvarez et al., Córdoba, Argentina. In Eur J Cell Biol, 2011
Rab1b is a key regulatory component of COPII dynamics and function.
Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase.
Brumell et al., Toronto, Canada. In Autophagy, 2011
Antibacterial autophagy occurs at omegasomes and reveal that the Rab1 GTPase plays a crucial role in mammalian autophagy.
Role of the GTPase Rab1b in ebolavirus particle formation.
Kawaoka et al., Tokyo, Japan. In J Virol, 2010
The authors demonstrate that Rab1b-activated GBF1 and ARF1 are involved in Ebolavirus virion formation, suggesting that both the COPII and COPI transport systems play a role in Ebolavirus VP40-mediated particle formation.
Rheb and mTOR regulate neuronal polarity through Rap1B.
Püschel et al., Münster, Germany. In J Biol Chem, 2008
Inhibition of PI3K or mTOR reduced the level of Rap1B, which acts downstream of Rheb and mTOR. The ubiquitin E3 ligase Smurf2 mediates the restriction of Rap1B by initiating its degradation.
Neurogenin 2 controls cortical neuron migration through regulation of Rnd2.
Guillemot et al., London, United Kingdom. In Nature, 2008
Here we show that the proneural protein neurogenin 2 (Neurog2), which controls neurogenesis in the embryonic cerebral cortex, directly induces the expression of the small GTP-binding protein Rnd2 (ref.
The Rab8 GTPase regulates apical protein localization in intestinal cells.
Harada et al., Japan. In Nature, 2007
The small GTP-binding protein Rab8 was thought to regulate basolateral transport in polarized kidney epithelial cells through the AP1B-complex-mediated pathway.
Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome.
Leroux et al., Canada. In Nat Genet, 2004
These findings implicate a small GTP-binding protein in ciliary transport and the pathogenesis of a pleiotropic disorder.
The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras.
Negishi et al., Kyoto, Japan. In Science, 2004
This activity required the interaction of Plexin-B1 with Rnd1, a small GTP-binding protein of the Rho family.
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