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RAB18 dehydrin Rab18

RAB18
The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: ACID, Rab5, CAN, HAD, abi1
Papers on RAB18
Biological Control Activities of Rice-Associated Bacillus sp. Strains against Sheath Blight and Bacterial Panicle Blight of Rice.
New
Ham et al., Chiang Rai, Thailand. In Plos One, Dec 2015
The five selected RABs showing highest antimicrobial activities (RAB6, RAB9, RAB16, RAB17S, and RAB18) were closest to B. amyloliquefaciens in DNA sequence of 16S rDNA and gyrB, but to B. subtilis in that of recA.
Phospholipase D δ knock-out mutants are tolerant to severe drought stress.
New
Laxalt et al., Mar del Plata, Argentina. In Plant Signal Behav, Dec 2015
We further analyzed the mutants and showed that pldδ have higher mRNA levels of RAB18 and RD29A compared to wild-type plants under normal growth conditions.
Exposure of two Eutrema salsugineum (Thellungiella salsuginea) accessions to water deficits reveals different coping strategies in response to drought.
New
Weretilnyk et al., Hamilton, Canada. In Physiol Plant, Nov 2015
The drought-responsive expression of dehydrin genes RAB18, ERD1, RD29A and RD22 showed greater changes in transcript abundance in Yukon relative to Shandong leaves during both water deficits and recovery with the greatest difference in expression appearing during the second drought.
Arabidopsis PED2 positively modulates plant drought stress resistance.
New
Chan et al., Haikou, China. In J Integr Plant Biol, Sep 2015
Notably, AtPED2 positively modulated expression of several stress-responsive genes (RAB18, RD22, RD29A, and RD29B), positively affected underlying antioxidant enzyme activities and negatively regulated reactive oxygen species (ROS) level under drought stress conditions.
Involvement of genes encoding ABI1 protein phosphatases in the response of Brassica napus L. to drought stress.
New
Sadowski et al., Poznań, Poland. In Plant Mol Biol, Jul 2015
Transgenic plants subjected to drought showed a decrease in relative water content, photosynthetic pigments content and expression level of RAB18- and RD19A-drought-responsive marker genes relative to WT plants.
Warburg Micro syndrome is caused by RAB18 deficiency or dysregulation.
New
FitzPatrick et al., Milwaukee, United States. In Open Biol, Jun 2015
RAB18, RAB3GAP1, RAB3GAP2 and TBC1D20 are each mutated in Warburg Micro syndrome, a rare autosomal recessive multisystem disorder.
Deletion 1q43-44 in a patient with clinical diagnosis of Warburg-Micro syndrome.
New
Luisa Martínez-Frías et al., Cáceres, Spain. In Am J Med Genet A, Jun 2015
This syndrome is caused by mutations in the RAB3GAP1/2 and RAB18 genes, part of the Rab family, and in the TBC1D20 gene, which contributes to lipid droplet formation/metabolism.
The Pepper Lipoxygenase CaLOX1 Plays a Role in Osmotic, Drought and High Salinity Stress Response.
New
Lee et al., Seoul, South Korea. In Plant Cell Physiol, May 2015
In contrast, expression of the ABA-responsive marker genes RAB18 and RD29B was higher in CaLOX1-OX Arabidopsis plants than in wild-type plants.
ENU mutagenesis identifies mice modeling Warburg Micro Syndrome with sensory axon degeneration caused by a deletion in Rab18.
New
Hong et al., Taipei, Taiwan. In Exp Neurol, May 2015
Mutations in the gene of RAB18, a member of Ras superfamily of small G-proteins, cause Warburg Micro Syndrome (WARBM) which is characterized by defective neurodevelopmental and ophthalmological phenotypes.
Identification of TaWD40D, a wheat WD40 repeat-containing protein that is associated with plant tolerance to abiotic stresses.
New
Li et al., Shijiazhuang, China. In Plant Cell Rep, Mar 2015
The expression patterns of two genes from the SOS pathway (SOS2 and SOS3) and three ABA genes (ABI2, RAB18 and DREB2A) functioning in ABA-dependent and ABA-independent pathways were altered in the transgenic lines overexpressing TaWD40D under the treatments.
CmWRKY15 Facilitates Alternaria tenuissima Infection of Chrysanthemum.
Chen et al., Nanjing, China. In Plos One, 2014
To illustrate the mechanisms by which CmWRKY15 regulates the response to A. tenuissima inoculation, the expression levels of ABA-responsive and ABA signaling genes, such as ABF4, ABI4, ABI5, MYB2, RAB18, DREB1A, DREB2A, PYL2, PP2C, RCAR1, SnRK2.2,
Large homozygous RAB3GAP1 gene microdeletion causes Warburg micro syndrome 1.
Kaindl et al., In Orphanet J Rare Dis, 2013
WARBM1-4 can be caused by biallelic mutations of the RAB3GAP1 (RAB3 GTPase-activating protein 1), RAB3GAP2, RAB18 (RAS-associated protein RAB18), or TBC1D20 (TBC1 domain protein, member 20) gene, respectively.
Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice.
Sidjanin et al., Milwaukee, United States. In Bmc Genet, 2013
In addition to TBC1D20, mutations in RAB3GAP1, RAB3GAP2 and RAB18 cause WARBM1-3 respectively.
RAB3GAP1, RAB3GAP2 and RAB18: disease genes in Micro and Martsolf syndromes.
Review
Aligianis et al., Edinburgh, United Kingdom. In Biochem Soc Trans, 2013
Micro syndrome has been associated with causative mutations in three disease genes: RAB3GAP1, RAB3GAP2 and RAB18.
WRKY transcription factors: key components in abscisic acid signalling.
Review
Rushton et al., Brookings, United States. In Plant Biotechnol J, 2012
In vivo and in vitro promoter-binding studies show that the target genes for WRKY TFs that are involved in ABA signalling include well-known ABA-responsive genes such as ABF2, ABF4, ABI4, ABI5, MYB2, DREB1a, DREB2a and RAB18.
Loss-of-function mutations in RAB18 cause Warburg micro syndrome.
GeneRIF
Aligianis et al., Birmingham, United Kingdom. In Am J Hum Genet, 2011
performed autozygosity mapping in five consanguineous families with Warburg micro syndrome without RAB3GAP1/2 mutations and identified loss-of-function mutations in RAB18
Characterization of the brain proteome of rats with diabetes mellitus through two-dimensional electrophoresis and mass spectrometry.
GeneRIF
Ravikumar et al., Thanjāvūr, India. In Brain Res, 2011
Overexpression of brain RAB18 in alloxan diabetes leads to uneven distribution and function of intracellular-vesicular transport causing accumulation of protein inside the cell, this results in neurological disorder.
Rab18 and Rab43 have key roles in ER-Golgi trafficking.
GeneRIF
Presley et al., Montréal, Canada. In J Cell Sci, 2008
Rab18 and Rab43 have key roles in ER-Golgi trafficking.
Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion.
GeneRIF
Malagon et al., Córdoba, Spain. In J Clin Endocrinol Metab, 2008
Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion.
Rab18 inhibits secretory activity in neuroendocrine cells by interacting with secretory granules.
GeneRIF
Malagon et al., Córdoba, Spain. In Traffic, 2007
in neuroendocrine cells, Rab18 acts as a negative regulator of secretory activity, likely by impairing secretory granule transport
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