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RAB11 family interacting protein 3

Rab11-FIP3, Rab11-Family Interacting Protein 3, KIAA0665
Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008] (from NCBI)
Papers on Rab11-FIP3
A novel cytoplasmic adaptor for retinoic acid receptor (RAR) and thyroid receptor functions as a Derepressor of RAR in the absence of retinoic acid.
GeneRIF
Um et al., Seoul, South Korea. In J Biol Chem, 2010
CART1 might be a cytoplasmic, testis-specific derepressor of RAR
Rab11-FIP3 binds dynein light intermediate chain 2 and its overexpression fragments the Golgi complex.
GeneRIF
McCaffrey et al., Cork, Ireland. In Biochem Biophys Res Commun, 2010
FIP3 was identified as the first membrane-associated interacting-partner for DLIC-2.
Rab11-FIP3 is a Rab11-binding protein that regulates breast cancer cell motility by modulating the actin cytoskeleton.
GeneRIF
Prekeris et al., Aurora, United States. In Eur J Cell Biol, 2009
Rab11-FIP3 is a Rab11-binding protein that regulates breast cancer cell motility by modulating the actin cytoskeleton.(325-41)
Molecular characterization of Rab11-FIP3 binding to ARF GTPases.
GeneRIF
Prekeris et al., Aurora, United States. In Eur J Cell Biol, 2007
FIP3 is a scaffolding protein that, in addition to regulating endosome targeting to the cleavage furrow, also is required for Arf6 recruitment to the midbody during late telophase.
Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment.
GeneRIF
McCaffrey et al., Cork, Ireland. In Traffic, 2007
Necessary for the structural integrity of the pericentrosomal endosomal recycling compartment.
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