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RAB GTPase activating protein 1

Rab GTPase-activating protein, GAPCenA, RABGAP, RABGAP1
Top mentioned proteins: Rab5, GAP, Insulin, AS160, Akt
Papers on Rab GTPase-activating protein
Rab-GAP TBC1D4 (AS160) is dispensable for the renal control of sodium and water homeostasis but regulates GLUT4 in mouse kidney.
New
Loffing et al., Zürich, Switzerland. In Am J Physiol Renal Physiol, Dec 2015
The Rab GTPase-activating protein TBC1D4 (AS160) controls trafficking of the glucose transporter GLUT4 in adipocytes and skeletal muscle cells.
Akt Substrate of 160 kD Regulates Na+,K+-ATPase Trafficking in Response to Energy Depletion and Renal Ischemia.
New
Caplan et al., Zürich, Switzerland. In J Am Soc Nephrol, Nov 2015
We previously reported that the subcellular distribution of Na(+),K(+)-ATPase is modulated by direct binding to Akt substrate of 160 kD (AS160), a Rab GTPase-activating protein that regulates the trafficking of glucose transporter 4 in response to insulin and muscle contraction.
Deletion of the Rab GAP Tbc1d1 modifies glucose, lipid, and energy homeostasis in mice.
New
Keller et al., Charlottesville, United States. In Am J Physiol Endocrinol Metab, Sep 2015
Tbc1d1 is a Rab GTPase-activating protein (GAP) implicated in regulating intracellular retention and cell surface localization of the glucose transporter GLUT4 and thus glucose uptake in a phosphorylation-dependent manner.
Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery.
New
Weigert et al., Copenhagen, Denmark. In Diabetologia, Aug 2015
RESULTS: Pathway analysis of differentially regulated genes upon exercise revealed upregulation of regulators of GLUT4 (SLC2A4RG, FLOT1, EXOC7, RAB13, RABGAP1 and CBLB), glycolysis (HK2, PFKFB1, PFKFB3, PFKM, FBP2 and LDHA) and insulin signal mediators in diabetic participants compared with controls.
Identification of a Rab GTPase-activating protein cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole.
New
Ungermann et al., Osnabrück, Germany. In Mol Biol Cell, Aug 2015
Transport within the endocytic pathway depends on a consecutive function of the endosomal Rab5 and the late endosomal/lysosomal Rab7 GTPases to promote membrane recycling and fusion in the context of endosomal maturation.
Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR.
New
Impact
Esteller et al., Barcelona, Spain. In Nat Med, Jul 2015
We found a hypomethylation event that reactivates a cryptic transcript of the Rab GTPase activating protein TBC1D16 (TBC1D16-47 kDa; referred to hereafter as TBC1D16-47KD) to be a characteristic feature of the metastatic cascade.
[6]-Gingerol Affects Glucose Metabolism by Dual Regulation via the AMPKα2-Mediated AS160-Rab5 Pathway and AMPK-Mediated Insulin Sensitizing Effects.
New
Kim et al., Seoul, South Korea. In J Cell Biochem, Jul 2015
In addition, [6]-gingerol increased the phosphorylation of Akt-substrate 160 (AS160), which is a Rab GTPase-activating protein.
Carabin protects against cardiac hypertrophy by blocking calcineurin, Ras, and Ca2+/calmodulin-dependent protein kinase II signaling.
New
Lezoualc'h et al., Montpellier, France. In Circulation, Feb 2015
Indeed, Carabin, through its calcineurin-interacting site and Ras/Rab GTPase-activating protein domain, functions as an endogenous inhibitor of calcineurin and Ras/extracellular signal-regulated kinase prohypertrophic signaling.
PKB-Mediated Thr649 Phosphorylation of AS160/TBC1D4 Regulates the R-Wave Amplitude in the Heart.
Chen et al., Nanjing, China. In Plos One, 2014
The Rab GTPase activating protein (RabGAP), AS160/TBC1D4, is an important substrate of protein kinase B (PKB), and regulates insulin-stimulated trafficking of glucose transporter 4. Besides, AS160/TBC1D4 has also been shown to regulate trafficking of many other membrane proteins including FA translocase/CD36 in cardiomyocytes.
Measuring Rab GTPase-activating protein (GAP) activity in live cells and extracts.
Pfeffer et al., Stanford, United States. In Methods Mol Biol, 2014
Mammalian cells encode a diverse set of Rab GTPases and their corresponding regulators.
The JNK1/JNK3 interactome--contributions by the JNK3 unique N-terminus and JNK common docking site residues.
Bogoyevitch et al., Melbourne, Australia. In Biochem Biophys Res Commun, 2014
ΔN JNK3α1), and interaction evaluation in the yeast two-hybrid system defined the interacting partners as either JNK1-specific interactors (ATF7, FUS, KCNE4, PIAS1, SHANK1, TKT), typical JBD-dependent interactors shared by JNK1α1 and JNK3α1 (AKAP6, BMPR2, EEF1A1, GFAP, GRIP2, GTF2F1, HDAC2, MAP1B, MYO9B, PTPN2, RABGAP1, RUSC2, SUMO1, SYPL1, TOPBP1, ZNF668), or JNK3-specific partners (ATXN1, NNAT, PTGDS) dependent on interaction with the JNK3 N-terminal extension.
E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy.
Swarup et al., Hyderābād, India. In Plos One, 2013
The protein optineurin coded by OPTN gene is involved in several functions including regulation of endocytic trafficking, autophagy and signal transduction.
Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy.
Youle et al., Bethesda, United States. In Elife, 2013
In this study, we demonstrate that TBC1D15, a mitochondrial Rab GTPase-activating protein (Rab-GAP), governs autophagosome biogenesis and morphology downstream of Parkin activation.
Regulation of ion channels and transporters by AMP-activated kinase (AMPK).
Review
Föller et al., Tübingen, Germany. In Channels (austin), 2013
AMPK further regulates transport proteins by inhibition of Rab GTPase activating protein (GAP) TBC1D1.
Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein.
Impact
McGraw et al., New York City, United States. In Cell Metab, 2005
Here, we show that the AS160 Rab GTPase activating protein (GAP) is a negative regulator of basal GLUT4 exocytosis.
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