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Rab geranylgeranyltransferase, alpha subunit

Rab geranylgeranyltransferase, PTAR3, RABGGTA
Top mentioned proteins: Rab5, TCD, CAN, YPT1, Rab7
Papers on Rab geranylgeranyltransferase
Molecular characterization and identification of target protein of an important vesicle trafficking gene AlRab7 from a salt excreting halophyte Aeluropus lagopoides.
New
Agarwal et al., Bhāvnagar, India. In Dna Cell Biol, Feb 2015
The in silico analysis predicts the presence of the prenylation site for Rab geranylgeranyltransferase 2 and the Rab escort protein site.
Prenylation is required for polar cell elongation, cell adhesion, and differentiation in Physcomitrella patens.
Running et al., Saint Louis, United States. In Plant J, 2014
The complete loss of Rab geranylgeranyltransferase activity appears to be lethal in P. patens.
Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.
Bellen et al., Houston, United States. In Plos Biol, 2014
Here, we describe a novel and conserved Rab geranylgeranyltransferase (RabGGT)-α-like subunit that is required for Notch signaling-mediated lateral inhibition and cell fate determination of external sensory organs.
Regulation of β2-adrenergic receptor maturation and anterograde trafficking by an interaction with Rab geranylgeranyltransferase: modulation of Rab geranylgeranylation by the receptor.
Parent et al., Sherbrooke, Canada. In J Biol Chem, 2011
Here, we show that the β(2)-adrenergic receptor (β(2)AR) interacts with the Rab geranylgeranyltransferase α-subunit (RGGTA).
Mechanism of statin-induced contractile dysfunction in rat cultured skeletal myofibers.
Kimura et al., Fukushima, Japan. In J Pharmacol Sci, 2009
A selective Rab geranylgeranyltransferase (GG transferase) inhibitor, perillyl alcohol (POH), and a specific GG transferase-I inhibitor, GGTI-298, both mimicked Flv in decreasing ATP and contraction.
Caenorhabditis elegans Rab escort protein (REP-1) differently regulates each Rab protein function and localization in a tissue-dependent manner.
Doi et al., Tsukuba, Japan. In Genes Cells, 2008
This modification is preceded by the formation of a trimeric protein complex with the Rab escort protein (REP) and the Rab geranylgeranyltransferase (RabGGTase).
Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds.
Tamanoi et al., Los Angeles, United States. In J Biol Chem, 2008
Protein geranylgeranyltransferase I (GGTase-I) and Rab geranylgeranyltransferase (RabGGTase) catalyze these modifications.
Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression.
Hansen et al., Copenhagen, Denmark. In Hum Genet, 2008
In addition, an LOD score of Z = 4.21 between hair color and D14S72 was obtained in the large family, indicating that RABGGTA is a candidate gene for hair color.
Development of a series of P(CH(2)N=CHR)(3) and trisubstituted 1,3,5-Triaza-7-phosphaadamantane ligands.
Frost et al., Reno, United States. In Inorg Chem, 2008
Depending on the reaction conditions, either substituted tris(iminomethyl)phosphine, P(CH2N=CHR)3, or 1,3,5-triaza-7-phosphaadamantane structures substituted at the "lower rim", PTAR3, are obtained.
The structural and mechanistic basis for recycling of Rab proteins between membrane compartments.
Review
Alexandrov et al., Dortmund, Germany. In Cell Mol Life Sci, 2005
This cycle is mediated by geranylgeranylation of (usually) two C-terminal cysteines, which in turn is effected by Rab geranylgeranyltransferase in concert with REP (Rab escort protein).
Protein farnesylation: implications for normal physiology, malignant transformation, and cancer therapy.
Review
Impact
Sebti, Tampa, United States. In Cancer Cell, 2005
Furthermore, Rab geranylgeranyltransferase was identified as a target for some FTIs.
Choroideremia gene testing.
Review
Mah et al., Edmonton, Canada. In Expert Rev Mol Diagn, 2004
All mutations in the choroideremia gene result in the truncation or absence of the normal protein product Rab escort protein-1, which is a component of Rab geranylgeranyltransferase, an enzyme complex that mediates correct intracellular vesicular transport.
Structure, mechanism and function of prenyltransferases.
Review
Wang et al., Taipei, Taiwan. In Eur J Biochem, 2002
For protein prenyltransferases, the structures of Ras farnesyltransferase and Rab geranylgeranyltransferase are used to elucidate the reaction mechanism of this group of enzymes.
The leucine-rich repeat as a protein recognition motif.
Review
Kajava et al., Brisbane, Australia. In Curr Opin Struct Biol, 2001
The new structures represent different LRR subfamilies and proteins with diverse functions, including GTPase-activating protein rna1p from the ribonuclease-inhibitor-like subfamily; spliceosomal protein U2A', Rab geranylgeranyltransferase, internalin B, dynein light chain 1 and nuclear export protein TAP from the SDS22-like subfamily; Skp2 from the cysteine-containing subfamily; and YopM from the bacterial subfamily.
Structure and mutational analysis of Rab GDP-dissociation inhibitor.
Impact
Balch et al., Los Angeles, United States. In Nature, 1996
Sequence-conserved regions common to GDI and the choroideraemia gene product, which delivers Rab to catalytic subunits of Rab geranylgeranyltransferase II, are clustered on one face of the molecule.
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