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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cadherin 4, type 1, R-cadherin

R-cadherin, cadherin-4, CDH4, CAD-4
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: N-cadherin, E-cadherin, CAN, cadherin-7, cadherin-11
Papers on R-cadherin
P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces.
Gauthier-Rouvière et al., Montpellier, France. In J Cell Biol, Feb 2016
This mechanism of cell polarization and migration is absent in cells expressing E- or R-cadherin.
[Ability to detect psychiatric disorders by the family physician].
Fuentes et al., Madrid, Spain. In Aten Primaria, Feb 2016
MAIN MEASUREMENTS: To detect psychiatric disorders in the waiting room, an interview was performed using GHQ-28 and MULTICAGE CAD-4 in the screening phase (considered positive: score of 6 or higher on the GHQ-28 or a score 2 or higher on MULTICAGE CAD-4).
Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells.
Di Bartolomeo et al., Roma, Italy. In Mol Oncol, Oct 2015
Conversely, in BECLIN 1-silenced GBM cells, an increased migration capability and an up-regulation of SNAIL and SLUG was observed, with a resulting decrease in N- and R-cadherin mRNAs.
Next-Generation Sequencing of Pulmonary Sarcomatoid Carcinoma Reveals High Frequency of Actionable MET Gene Mutations.
Borczuk et al., Guangzhou, China. In J Clin Oncol, Aug 2015
RESULTS: In addition to confirming mutations in known cancer-associated genes (TP53, KRAS, PIK3CA, MET, NOTCH, STK11, and RB1), several novel mutations in additional genes, including RASA1, CDH4, CDH7, LAMB4, SCAF1, and LMTK2, were identified and validated.
A cadherin switch underlies malignancy in high-grade gliomas.
Malatesta et al., Genova, Italy. In Oncogene, May 2015
Here we propose that the blinding of cell-cell contact sensing in gliomas is caused by an unusual mechanism of cadherin switch, involving the replacement of N-cadherin with R-cadherin (Rcad) at the cell-cell junctions and the activation of ERK and p27.
Comparative detection of aberrantly methylated DNA in preoperative and postoperative stool from patients with colorectal cancers.
Tanaka et al., In Int J Biol Markers, 2015
Aberrant promoter methylation of CDH4 and GATA5 was assessed in the primary tumors by methylation-specific polymerase chain reaction (MSP) and in stool samples by real-time MSP.
Regulation of UHRF1 by miR-146a/b modulates gastric cancer invasion and metastasis.
Wu et al., Xi'an, China. In Faseb J, 2013
Furthermore, the restoration of miR-146a/b dramatically reduced the expression of UHRF1 through the direct targeting of its 3'-UTR, and this effect in turn reactivated the slit homologue 3 (Slit3), cadherin 4 (CDH4), and runt-related transcription factor 3 (RUNX3) genes via promoter demethylation.
['Nothing' or 'just a bit'? 'Much' or 'too much'? Impulsivity traits as markers of severity transitions within non-problematic and problematic ranges of alcohol and Internet use].
J C et al., In Adicciones, 2013
For this, 709 first-year college students were assessed using the UPPS-P impulsive behavior scale, and the Multicage CAD-4 scale for addictive behaviors.
De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity.
Marciano et al., Dallas, United States. In Development, 2013
Absence of afadin led to delayed and diminished integration of nectin complexes and failure to recruit R-cadherin.
20q13.2-q13.33 deletion syndrome: A case report.
Schroeder et al., Kansas City, United States. In J Pediatr Genet, 2012
Clinical features and genetic findings with the loss of 30 genes, including GNAS, MC3R, CDH4 and TFAP2C, are described in relationship to the very few cases of 20q13 deletion reported in the literature.
PP065. dNK and dNK-CM mediated alterations of DNA methylation in extravillous cytotrophoblasts (EVTS).
Robinson et al., Vancouver, Canada. In Pregnancy Hypertens, 2012
dNK-CM but not dNK reduced methylation of ITGAD and PCDH8 (protocadherin 8) and increased methylation of CDH4 and CDH6.
Chromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitor treatment.
Lin et al., Houston, United States. In J Biol Chem, 2012
Findings identify an important role of CHD4 in controlling homologous recombination repair to maintain genome stability and establish the potential therapeutic implications of targeting CHD4 deficiency in tumors.
CDH4 as a novel putative tumor suppressor gene epigenetically silenced by promoter hypermethylation in nasopharyngeal carcinoma.
Zhang et al., Nanning, China. In Cancer Lett, 2011
a novel putative tumor suppressor gene that can be frequently and tumor-specifically inactivated by its promoter methylation in nasopharyngeal carcinoma
The simultaneous repression of CCR and CAD, two enzymes of the lignin biosynthetic pathway, results in sterility and dwarfism in Arabidopsis thaliana.
Jouanin et al., Versailles, France. In Mol Plant, 2011
Repressing both the CAD and the CCR activities results in sterility and dwarfism.
Investigations of the bond-selective response in a piezoelectric Li2SO4.H2O crystal to an applied external electric field.
Pietsch et al., Siegen, Germany. In Acta Crystallogr A, 2009
The static electron density was determined via standard low-temperature X-ray data collection at 90 (5) K using an Enraf-Nonius CAD-4 diffractometer, Mo Kalpha radiation and multipole model refinement.
Loss of retinal cadherin facilitates mammary tumor progression and metastasis.
Hazan et al., United States. In Cancer Res, 2009
suggest that R-cad is an adhesion molecule of the mammary epithelium, which acts as a critical regulator of the normal phenotype
Cadherin-4 plays a role in the development of zebrafish cranial ganglia and lateral line system.
Liu et al., Akron, United States. In Dev Dyn, 2007
Results indicate that Cdh4 plays a role in the normal formation of the zebrafish lateral line system and a subset of the cranial ganglia.
Endothelial cadherins and tumor angiogenesis.
Dejana et al., Italy. In Exp Cell Res, 2006
T cadherin, R-cadherin and VE-cadherin 2 were found in specific regions of the vascular tree but their role in vascular development or angiogenesis is still unclear.
Patch/matrix patterns of gray matter differentiation in the telencephalon of chicken and mouse.
Puelles et al., Essen, Germany. In Brain Res Bull, 2002
In the avian neostriatum, cadherin-7-positive cell clusters ("islands") are surrounded by a matrix of cells that express R-cadherin.
M-cadherin and its sisters in development of striated muscle.
Starzinski-Powitz et al., Frankfurt am Main, Germany. In Cell Tissue Res, 1999
In the development of striated muscle, the expression and function of mainly M-, N-, and R-cadherin has been studied so far.
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