Implications of NQO1 in cancer therapy.
Inch'ŏn, South Korea. In Bmb Rep, Nov 2015
NAD(P)H: quinone oxidoreductase (NQO1), an obligatory two-electron reductase, is a ubiquitous cytosolic enzyme that catalyzes the reduction of quinone substrates.
Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase.
Stuttgart, Germany. In Nature, 2015
The sodium-translocating NADH:quinone oxidoreductase (Na(+)-NQR), a membrane protein complex widespread among pathogenic bacteria, consists of six subunits, NqrA, B, C, D, E and F. To our knowledge, no structural information on the Na(+)-NQR complex has been available until now.
Nanotechnology-enabled delivery of NQO1 bioactivatable drugs.
Dallas, United States. In J Drug Target, 2014
β-Lapachone (β-lap) is a novel anticancer agent whose mechanism of action is highly dependent on NAD(P)H: quinone oxidoreductase 1 (NQO1), a phase II detoxifying enzyme overexpressed in solid tumors from a variety of cancer types.