The RNA binding protein quaking regulates formation of circRNAs.
Adelaide, Australia. In Cell, Apr 2015
We show that hundreds of circRNAs are regulated during human epithelial-mesenchymal transition (EMT) and find that the production of over one-third of abundant circRNAs is dynamically regulated by the alternative splicing factor, Quaking (QKI), which itself is regulated during EMT.
RNA-binding proteins in neurological diseases.
In Sci China Life Sci, 2014
Here, we mainly focus on selected RNA-binding proteins including Nova-1/Nova-2, HuR/HuB/HuC/HuD, TDP-43, Fus, Rbfox1/Rbfox2, QKI and FMRP, discussing their function and roles in human diseases.
The star family member QKI and cell signaling.
Atlanta, United States. In Adv Exp Med Biol, 2009
This chapter provides a short review of the STAR member QKI, focusing on the essential role of QKI in development of the central nervous system, possible mechanisms by which QKI may link cell signaling to the cellular behavior of its mRNA targets and how QKI dysregulation may contribute to human diseases.