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Zinc finger protein 91 homolog
Pzf, zinc finger protein 91, Zfp91
The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010] (from
NCBI)
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Papers on
Pzf
An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination.
GeneRIF
South Korea. In J Biol Chem, 2010
An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination.
Zinc-finger protein 91 plays a key role in LIGHT-induced activation of non-canonical NF-κB pathway.
GeneRIF
South Korea. In Biochem Biophys Res Commun, 2010
Functional analysis of the human ZFP91 protein.
A retroviral vector common integration site between leupaxin and zinc finger protein 91 (ZFP91) observed in baboon hematopoietic repopulating cells.
Seattle, United States. In Exp Hematol, 2010
RESULTS: In three different animals that received gammaretrovirally transduced CD34-enriched bone marrow cells, vector proviruses were identified at three distinct sites within a window of 664 base pairs between leupaxin and zinc finger protein 91 (ZFP91).
Long-term functional improvement and gene expression changes after bone marrow-derived multipotent progenitor cell transplantation in myocardial infarction.
Minneapolis, United States. In Am J Physiol Heart Circ Physiol, 2010
MPC transplantation was associated with a downregulation of mitochondrial oxidative enzymes and increased levels of myocyte enhancer factor 2a and zinc finger protein 91.
Transcriptional analysis of buffalo (Bubalus bubalis) oocytes during in vitro maturation using bovine cDNA microarray.
Al Jīzah, Egypt. In Reprod Domest Anim, 2010
Among these, transcription factors (ZFP91), M-phase mitotic cell cycle (MPHOSPH9), growth factor (BMP15) and DNA binding (HMGN2) were found to be up-regulated in immature oocytes.
Zinc finger-mediated live cell imaging in Arabidopsis roots.
Leiden, Netherlands. In Methods Mol Biol, 2009
A module of consecutive zinc finger domains, designated a polydactyl zinc finger (PZF) domain, is thus capable of binding an extended number of base pairs of DNA.
Reduction of late in-stent stenosis in a porcine coronary artery model by cobalt chromium stents with a nanocoat of polyphosphazene (Polyzene-F).
Heidelberg, Germany. In Cardiovasc Intervent Radiol, 2008
The purpose of this study was to investigate the potential of nanoscale coating with the highly biocompatible polymer Polyzene-F (PZF), in combination with cobalt chromium and stainless steel stents, to reduce in-stent stenosis, thrombogenicity, and vessel wall injury and inflammation.
Live cell imaging of repetitive DNA sequences via GFP-tagged polydactyl zinc finger proteins.
Leiden, Netherlands. In Nucleic Acids Res, 2006
We constructed several polydactyl zinc finger (PZF) DNA-binding domains aimed to recognize specific DNA sequences in Arabidopsis and mouse and fused these with GFP.
Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia.
GeneRIF
Tokyo, Japan. In Int J Oncol, 2003
likely to play an important role in cell proliferation and/or anti-apoptosis, and may serve as a molecular marker for AML
The Ginkgo biloba extract EGb 761 increases viability of hnt human neurons in culture and affectsthe expression of genes implicated in the stress response.
Paris, France. In Cell Mol Biol Incl Cyto Enzymol, 2002
Three groups are distinguished: genes encoding transcription factors (increase of NF-kappaB p65 subunit and zinc finger protein 91 mRNAs, and decrease of c-myc transcripts), genes involved in antioxidant defenses (increase of the CuZn SOD mRNAs, and decrease of glutathione reductase and glutathione S-transferase pi mRNAs) and genes involved in stress responses (up-regulation of HSP70 transcripts).
Restriction of a Sindbis virus mutant in BHK cells and relief of the restriction by the addition of adenosine.
United States. In Virology, 2002
SV(PZF) is a mutant of Sindbis virus (SV) which we selected on the basis of its ability to replicate in mosquito cells treated with pyrazofurin (PZF), a drug which inhibits pyrimidine nucleotide biosynthesis (Lin et al., 2000, Virology 272, 61-71).
A mutant of Sindbis virus that is resistant to pyrazofurin encodes an altered RNA polymerase.
United States. In Virology, 2000
Pyrazofurin (PZF), a cytidine analog and an inhibitor of orotate monophosphate decarboxylase, has been shown to decrease the levels of UTP and CTP in treated cells.
Identification of genes responsive to BPDE treatment in HeLa cells using cDNA expression assays.
Victoria, Canada. In Environ Mol Mutagen, 1999
The protein products of these genes are: fos-related antigen 2, apoptotic cysteine protease MCH4, DB1 (zinc finger protein 91), transcription factor ETR103, integrin alpha, interleukin-4, interleukin-6, 23-kDa highly basic protein, and ribosomal protein S9.
Multiplex differential display identifies a novel zinc-finger protein repressed during withdrawal from cocaine.
Belmont, United States. In Brain Res Mol Brain Res, 1997
The DNA sequence of 8G226 exhibited near identity with a mouse zinc-finger protein (PZf) and is thus likely to represent a transcriptional regulator.
Coronary physiology.
Review
Impact
In Physiol Rev, 1983
However, the unexpected finding of zero flow during a prolonged diastole with a coronary artery pressure of 40 mmHg (PZF) is a reminder that the physical forces, including vascular smooth muscle contraction, that determine coronary vascular resistance are incompletely understood.
