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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Protein Z, vitamin K-dependent plasma glycoprotein

This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] (from NCBI)
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Top mentioned proteins: HAD, CAN, AGE, ACID, Cholecystokinin
Papers on PZ
Contribution of protein Z gene single-nucleotide polymorphism to systemic lupus erythematosus in Egyptian patients.
Refai et al., Cairo, Egypt. In Blood Coagul Fibrinolysis, Feb 2016
Polymorphisms in the protein Z gene (PROZ) may affect protein Z levels and thus play a role in thrombosis.
Can prostatic arterial embolisation (PAE) reduce the volume of the peripheral zone? MRI evaluation of zonal anatomy and infarction after PAE.
Sapoval et al., Paris, France. In Eur Radiol, Feb 2016
METHODS: We retrospectively reviewed paired MRI scans obtained before and after PAE for 25 patients and evaluated changes in volumes of the median lobe (ML), central gland (CG), peripheral zone (PZ) and whole prostate gland (WPV) following PAE.
Stratification of the aggressiveness of prostate cancer using pre-biopsy multiparametric MRI (mpMRI).
Jagannathan et al., New Delhi, India. In Nmr Biomed, Feb 2016
A total of 910 regions of interest (ROIs) from the peripheral zone (PZ, range 25-45) were analyzed from these 26 patients.
Improved xylitol production from D-arabitol by enhancing the coenzyme regeneration efficiency of the pentose phosphate pathway in Gluconobacter oxydans.
Feng et al., In J Agric Food Chem, Feb 2016
Approximately 29.3 g/L xylitol was obtained, with a yield of 73.2%, from 40 g/L D-arabitol in the batch biotransformation with the G. oxydans PZ strain.
Daily consumption of ready-to-use peanut-based therapeutic food increased fat free mass, improved anemic status but has no impact on the zinc status of people living with HIV/AIDS: a randomized controlled trial.
Wade et al., Dakar, Senegal. In Bmc Public Health, Dec 2015
Hemoglobin was measured by HemoCue and plasma zinc (PZ) concentration by atomic absorption spectrometry.
Treatment-related fatigue with sorafenib, sunitinib and pazopanib in patients with advanced solid tumors: an up-to-date review and meta-analysis of clinical trials.
Cascinu et al., Ancona, Italy. In Int J Cancer, 2015
We performed an up-to-date meta-analysis to determine the incidence and relative risk (RR) of fatigue in patients (pts) with cancer treated with sorafenib (SO), sunitinib (SU) and pazopanib (PZ).
Statins for primary prevention of venous thromboembolism.
Yang et al., Lanzhou, China. In Cochrane Database Syst Rev, 2013
Disagreements were resolved by discussion with a third author (PZ Zhang).
Protein Z, an anticoagulant protein with expanding role in reproductive biology.
Almawi et al., Manama, Bahrain. In Reproduction, 2013
PZ deficiency has also been reported to be constitutional, and a number of variants in the PROZ (PZ) gene and SERPINA10 (ZPI) gene are linked with specific adverse pregnancy complications.
Structural basis for catalytic activation of protein Z-dependent protease inhibitor (ZPI) by protein Z.
Olson et al., Chicago, United States. In Blood, 2012
The study shows by Ala-scanning mutagenesis of the ZPI-binding interface, together with native PAGE and kinetic analyses of PZ binding to ZPI, that Tyr240 and Asp293 of ZPI are crucial hot spots for PZ binding.
Protein Z polymorphisms associated with vaso-occlusive crisis in young sickle cell disease patients.
Almawi et al., Manama, Bahrain. In Ann Hematol, 2012
Specific PZ variants and haplotypes are significantly associated with Sickle cell disease Vaso-Occlusive Crisis.
Intron F G79A polymorphism of the protein Z gene in Turkish Behçet patients.
Akar et al., Tokat, Turkey. In Curr Eye Res, 2012
Although thrombosis in Behcet disease is multifactorial, intron F G79A polymorphism of PZ gene in Behcet disease may be one of the factors that contribute to this pathological process
Protein Z/protein Z-dependent protease inhibitor system in human non-small-cell lung cancer tissue.
Kisiel et al., Białystok, Poland. In Thromb Res, 2012
Medium expression of ZPI(IRS=6.5), together with weak expression of PZ(IRS=4), was observed in cancer cells.
Co-localization of Protein Z, Protein Z-Dependent protease inhibitor and coagulation factor X in human colon cancer tissue: implications for coagulation regulation on tumor cells.
Kisiel et al., Białystok, Poland. In Thromb Res, 2012
localization of PZ/ZPI and FX in colon cancer cells indicates that PZ/ZPI may contribute to anticoagulant events at the tumor site.
The risk of occurrence of venous thrombosis: focus on protein Z.
Margaglione et al., Foggia, Italy. In Thromb Res, 2011
Protein Z (PZ) is a vitamin K-dependent factor identified in human plasma in 1984 characterized by an homology with other vitamin K-dependent factors.
The protein Z/protein Z-dependent protease inhibitor complex. Systemic or local control of coagulation?
Vasse, Rouen, France. In Hamostaseologie, 2011
it was shown that PZ and/or ZPI are synthesised by normal kidney and different cancer cells, suggesting that the complex PZ/ZPI could play a role in inhibiting the tissue deposition of fibrin. [review]
Stem-cell homeostasis and growth dynamics can be uncoupled in the Arabidopsis shoot apex.
Meyerowitz et al., Pasadena, United States. In Science, 2005
We show here that CLV3 restricts its own domain of expression (the CZ) by preventing differentiation of peripheral zone cells (PZ), which surround the CZ, into CZ cells and restricts overall SAM size by a separate, long-range effect on cell division rate.
Differential expression of S100A2 and S100A4 during progression of human prostate adenocarcinoma.
Mukhtar et al., Cleveland, United States. In J Clin Oncol, 2003
PATIENTS AND METHODS: Expression pattern of S100A2 and S100A4 was determined in normal human prostate epithelial cells (NHPE); virally transformed prostate epithelial cells (PZ-HPV-7); several human prostate carcinoma cells (22Rv1, DU145, LNCaP, and PC3); tissue samples obtained during transuretheral prostatic resection from patients with benign prostate hyperplasia (BPH), prostatitis, and adenocarcinoma; and paraffin-embedded sections from pair-matched benign and cancer specimens of different tumor grade.
Is the progress zone model a victim of progress?
Saunders, In Cell, 2002
The prevailing view has long been that mesenchymal cells at the apex of the vertebrate limb bud proliferate in a progress zone (PZ) under the influence of the apical ectodermal ridge (AER).
The SH2 tyrosine phosphatase shp2 is required for mammalian limb development.
Pawson et al., Toronto, Canada. In Nat Genet, 2000
Shp2 is specifically required in mesenchyme cells of the progress zone (PZ), directly beneath the distal ectoderm of the limb bud.
A novel member of the F-box/WD40 gene family, encoding dactylin, is disrupted in the mouse dactylaplasia mutant.
Lander et al., Stanford, United States. In Nat Genet, 1999
Early outgrowth of the vertebrate embryonic limb requires signalling by the apical ectodermal ridge (AER) to the progress zone (PZ), which in response proliferates and lays down the pattern of the presumptive limb in a proximal to distal progression.
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