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Dual specificity phosphatase 7

Pyst2, MKP-X, DUSP7
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009] (from NCBI)
Top mentioned proteins: MKP-3, MAPK, ERK, MKP-1, ERK1
Papers on Pyst2
Differential expression profiles and roles of inducible DUSPs and ERK1/2-specific constitutive DUSP6 and DUSP7 in microglia.
New
Choi et al., Seoul, South Korea. In Biochem Biophys Res Commun, Dec 2015
In contrast to the inducible DUSPs which also dephosphorylate p38 MAPK and JNK in the major inflammatory pathways, constitutive DUSP6 and DUSP7 are specific to ERK1/2 and have not been studied in microglia and other immune cells to date.
Identification of Bidentate Salicylic Acid Inhibitors of PTP1B.
New
Gunning et al., Toronto, Canada. In Acs Med Chem Lett, Oct 2015
Notably, 20f, which displayed a 5-fold selectivity for PTP1B over the closely related PTPĪƒ protein, showed no inhibition of PTP-LAR, PRL2 A/S, MKPX, or papain.
Structure of human dual-specificity phosphatase 7, a potential cancer drug target.
New
Waugh et al., Frederick, United States. In Acta Crystallogr Sect F Struct Biol Commun, Jun 2015
Human dual-specificity phosphatase 7 (DUSP7/Pyst2) is a 320-residue protein that belongs to the mitogen-activated protein kinase phosphatase (MKP) subfamily of dual-specificity phosphatases.
Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases.
Ulrich et al., Frederick, United States. In Plos One, 2014
We investigated the interactions of peptide substrates with select DUSPs of four types: MAP kinases (DUSP1 and DUSP7), atypical (DUSP3, DUSP14, DUSP22 and DUSP27), viral (variola VH1), and Cdc25 (A-C).
Identification of biomarkers for metastatic osteosarcoma based on DNA microarray data.
Wang, In Neoplasma, 2014
DEGs with high degrees (brain-specific angiogenesis inhibitor 2 (BAI2), formin-like 1 (FMNL1), dual-specificity phosphatase 7 (DUSP7), transient receptor potential melastatin 2 (TRPM2), CBP80/20-dependent translation initiation factor (KIAA0427) and C120rf35) in the differential coexpression network were found.
Celecoxib can suppress expression of genes associated with PGE2 pathway in chondrocytes under inflammatory conditions.
Weng et al., Changchun, China. In Int J Clin Exp Med, 2014
Among them, PTGS2, ADAMTS5, PTGER2, mPTGES and PTGER4 are known to be involved in chondrocyte inflammation, while VEGFA, BCL2, TRAF1, CYR61, BMP6, DAPK1, DUSP7, IL1RN, MMP13 and TNFSF10 were reported being associated with cytokine and chemokine signaling.
Chronic neuroprotective effects of low concentration lithium on SH-SY5Y cells: possible involvement of stress proteins and gene expression.
Review
Croute et al., Toulouse, France. In Neural Regen Res, 2014
cDNA arrays showed that pyruvate kinase 2 (PKM2) and calmodulin 3 (CaM 3) expression levels were significantly down-regulated, phosphatase protein PP2A expression was lightly down-regulated, and casein kinase II (CK2), threonine/tyrosine phosphatase 7 (PYST2), and dopamine beta-hydroxylase (DBH) expression levels were significantly up-regulated.
Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines.
Roschke et al., Bethesda, United States. In Cancer Genet, 2013
For the first time, LINGO2, RBFOX1/A2BP1, RPL29, DUSP7, and CCSER1/FAM190A were found to be homozygously deleted in MMt, and some of these genes could be new tumor suppressor genes for MMt.
MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7.
Dalton et al., Athens, United States. In Genes Dev, 2013
MYC/MAX complexes achieve this by binding the promoters of DUSP2 and DUSP7, leading to their transcriptional activation, resulting in the attenuation of ERK activity.
MAP kinase genes and colon and rectal cancer.
Wolff et al., Salt Lake City, United States. In Carcinogenesis, 2012
We assess 19 genes (DUSP1, DUSP2, DUSP4, DUSP6, DUSP7, MAP2K1, MAP3K1, MAP3K2, MAP3K3, MAP3K7, MAP3K9, MAP3K10, MAP3K11, MAPK1, MAPK3, MAPK8, MAPK12, MAPK14 and RAF1).
ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets.
Tarsounas et al., Oxford, United Kingdom. In Nat Commun, 2012
Specifically, ARF enables p53 transcription of Dusp4 and Dusp7, which encode a pair of phosphatases known to inactivate the MAP kinases ERK1/2.
Caspase-3 cleavage of DUSP6/MKP3 at the interdomain region generates active MKP3 fragments that regulate ERK1/2 subcellular localization and function.
Pulido et al., Valencia, Spain. In J Mol Biol, 2012
MKP3 possesses a linker region between its N-terminal MAPK-binding domain and its C-terminal catalytic domain, which is conserved in the related MKPs DUSP7/MKPX and DUSP9/MKP4.
Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways.
Keyse et al., Dundee, United Kingdom. In J Biol Chem, 2011
MAP kinase phosphatase 4 (DUSP9/MKP-4) plays an essential role during placental development and is one of a subfamily of three closely related cytoplasmic dual-specificity MAPK phosphatases, which includes the ERK-specific enzymes DUSP6/MKP-3 and DUSP7/MKP-X.
Genome-wide gain-of-function screen identifies novel regulators of pluripotency.
Ding et al., Los Angeles, United States. In Stem Cells, 2010
Conversely, the knockdown of the activating hits Timp2, Mki67ip, Esrrg, and Dusp7 in ES cells induced differentiation, whereas the knockdown of the reporter-inhibiting hit PU.1/Spi1 led to inhibition of differentiation.
Dual-specificity MAP kinase phosphatases (MKPs) and cancer.
Review
Keyse, Dundee, United Kingdom. In Cancer Metastasis Rev, 2008
The second group contains three closely related ERK-specific and cytoplasmic MKPs encoded by DUSP6/MKP-3, DUSP7/MKP-X and DUSP9/MKP-4.
Expression of ERK signaling inhibitors Dusp6, Dusp7, and Dusp9 during mouse ear development.
GeneRIF
Mansour et al., Salt Lake City, United States. In Dev Dyn, 2008
Data show that Dusp7 transcripts is expressed in partially overlapping patterns that correspond to regions of active FGF signaling, suggesting combinatorial roles in negative regulation of this pathway during ear development.
Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells.
GeneRIF
Witz et al., Tel Aviv-Yafo, Israel. In Oncogene, 2003
high levels of Pyst2-L detected in the active state of AML and ALL diseases and in other types of cancer reflect an altered MAPK signaling pathway in such malignant processes
cDNA microarray analysis reveals an overexpression of the dual-specificity MAPK phosphatase PYST2 in acute leukemia.
GeneRIF
Witz et al., Tel Aviv-Yafo, Israel. In Methods Enzymol, 2002
overexpressed in acute myelogenous leukemia
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