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Pyrroline-5-carboxylate reductase family, member 2

pyrroline-5-carboxylate reductase
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Top mentioned proteins: ACID, STEP, HAD, CAN, Arginase
Papers on pyrroline-5-carboxylate reductase
Downregulation of pyrroline-5-carboxylate reductase-2 induces the autophagy of melanoma cells via AMPK/mTOR pathway.
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Xu et al., Wenzhou, China. In Tumour Biol, Jan 2016
In the present study, we focused on the effect of pyrroline-5-carboxylate reductase-2 (PYCR2) on inducing autophagy process in melanoma.
Interaction of Mg with heavy metals (Cu, Cd) in T. aestivum with special reference to oxidative and proline metabolism.
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Sharma et al., Nagar, India. In J Plant Res, Dec 2015
This was due to decline in pyrroline-5-carboxylate synthetase (P5CS) and pyrroline-5-carboxylate reductase (P5CR) activity and enhanced proline dehydrogenase (PDH) activity.
Evolution of proline biosynthesis: enzymology, bioinformatics, genetics, and transcriptional regulation.
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Csonka et al., Tel Aviv-Yafo, Israel. In Biol Rev Camb Philos Soc, Nov 2015
In the most prevalent pathway of proline synthesis, glutamate is phosphorylated to γ-glutamyl phosphate by γ-glutamyl kinase, reduced to γ-glutamyl semialdehyde by γ-glutamyl phosphate reductase, cyclized spontaneously to Δ(1)-pyrroline-5-carboxylate and reduced to proline by Δ(1)-pyrroline-5-carboxylate reductase.
Grassland species differentially regulate proline concentrations under future climate conditions: an integrated biochemical and modelling approach.
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Asard et al., Antwerp, Belgium. In New Phytol, Oct 2015
Pyrroline-5-carboxylate synthetase (P5CS) and pyrroline-5-carboxylate reductase (P5CR) play a central role in grasses (Lolium perenne, Poa pratensis), and arginase (ARG), ornithine aminotransferase (OAT) and P5CR play a central role in legumes (Medicago lupulina, Lotus corniculatus).
Recurrent De Novo Mutations Affecting Residue Arg138 of Pyrroline-5-Carboxylate Synthase Cause a Progeroid Form of Autosomal-Dominant Cutis Laxa.
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Kornak et al., Berlin, Germany. In Am J Hum Genet, Oct 2015
They are caused by biallelic mutations in PYCR1 or ALDH18A1, encoding pyrroline-5-carboxylate reductase 1 and pyrroline-5-carboxylate synthase (P5CS), respectively, which both operate in the mitochondrial proline cycle.
Proline metabolism and cancer: emerging links to glutamine and collagen.
Review
Fischer et al., Frederick, United States. In Curr Opin Clin Nutr Metab Care, 2015
Of special interest, modulatory proteins such as parkinson protein 7 and oral cancer overexpressed 1 interact with pyrroline-5-carboxylate reductase, a critical component of the proline regulatory axis.
Functional properties and structural characterization of rice δ(1)-pyrroline-5-carboxylate reductase.
Nocek et al., Ferrara, Italy. In Front Plant Sci, 2014
The majority of plant species accumulate high intracellular levels of proline to cope with hyperosmotic stress conditions.
The structure of Medicago truncatula δ(1)-pyrroline-5-carboxylate reductase provides new insights into regulation of proline biosynthesis in plants.
Dauter et al., United States. In Front Plant Sci, 2014
The two pathways for proline biosynthesis in higher plants share the last step, the conversion of δ(1)-pyrroline-5-carboxylate (P5C) to L-proline, which is catalyzed by P5C reductase (P5CR, EC 1.5.1.2) with the use of NAD(P)H as a coenzyme.
Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production.
Nishio et al., Ōsaka, Japan. In Oncotarget, 2014
The peptide mass fingerprinting technique demonstrated that ORAOV1 bound to pyrroline-5-carboxylate reductase (PYCR), which is associated with proline metabolism and reactive oxygen species (ROS) production.
A PU.1 suppressive target gene, metallothionein 1G, inhibits retinoic acid-induced NB4 cell differentiation.
Takahashi et al., Sagamihara, Japan. In Plos One, 2013
Microarray analyses showed that the changes in expression of several myeloid differentiation-related genes (GATA2, azurocidin 1, pyrroline-5-carboxylate reductase 1, matrix metallopeptidase -8, S100 calcium-binding protein A12, neutrophil cytosolic factor 2 and oncostatin M) induced by ATRA were disturbed in NB4MTOE cells.
An Ipomoea batatas iron-sulfur cluster scaffold protein gene, IbNFU1, is involved in salt tolerance.
Liu et al., Beijing, China. In Plos One, 2013
Overexpression of IbNFU1 up-regulated pyrroline-5-carboxylate synthase (P5CS) and pyrroline-5-carboxylate reductase (P5CR) genes under salt stress.
A novel α/β-hydrolase gene IbMas enhances salt tolerance in transgenic sweetpotato.
Liu et al., Beijing, China. In Plos One, 2013
Overexpression of IbMas up-regulated the salt stress responsive genes, including pyrroline-5-carboxylate synthase, pyrroline-5-carboxylate reductase, SOD, psbA and phosphoribulokinase genes, under salt stress.
Proline biosynthesizing enzymes (glutamate 5-kinase and pyrroline-5-carboxylate reductase) from a model cyanobacterium for desiccation tolerance.
Asthana et al., Benares, India. In Physiol Mol Biol Plants, 2013
The genes encoding proline biosynthesizing enzymes, glutamate 5-kinase (G5K), and pyrroline-5-carboxylate reductase (P5CR) from the low-desiccation-tolerant cyanobacterium Anabaena sp.
The undifferentiated enzymic composition of human fetal lung and pulmonary tumors.
Review
Herzfeld et al., In Cancer Res, 1977
The characteristic abnormality in the overall pattern of enzymes, in the concentrations of individual ones, and in the quality of pyrroline-5-carboxylate reductase was clearly evident in both primary and metastatic tumors.
[Influence of NaCl- and abscisic acid treatment on protein metabolism and some further enzymes of amino acid metabolism in seedlings of Pennisetum typhoides].
Huber, München, Germany. In Planta, 1974
The effects of sodium chloride (NaCl) and abscisic acid (ABA) on protein synthesis, protein hydrolysis, glutamine synthetase, Δ-pyrroline-5-carboxylate reductase and amino acid composition have been studied in aerial parts of Pennisetum typhoides (Stapf et Hubbard) seedlings.
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