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pyridoxal kinase, PKH
The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, PLP, fibrillin-1
Papers on pyridoxal kinase
Effect of exogenous hormones on transcript levels of pyridoxal 5'-phosphate biosynthetic enzymes in the silkworm (Bombyx mori).
Huang et al., Hefei, China. In Comp Biochem Physiol B Biochem Mol Biol, Feb 2016
Through a salvage pathway, pyridoxal 5'-phosphate is synthesized from pyridoxal, pyridoxine or pyridoxamine, in a series of reactions catalyzed by pyridoxal kinase and pyridoxine 5'-phosphate oxidase.
Activation of 5-HT4 receptors facilitates neurogenesis from transplanted neural stem cells in the anastomotic ileum.
Takaki et al., Kashihara, Japan. In J Physiol Sci, Jan 2016
We found that neurons differentiated from transplanted NSCs (PKH [+]) and newborn enteric neurons differentiated from mobilized (host) NSCs (YFP [+]) in the deep granulation tissue of the anastomotic ileum.
Dietary supplementation with purified citrus limonin glucoside does not alter ex vivo functions of circulating T lymphocytes or monocytes in overweight/obese human adults.
Kelley et al., Davis, United States. In Nutr Res, Jan 2016
Peripheral blood mononuclear cells were prestained with PKH dye and activated with CD3 plus CD28 antibodies to determine the proliferative responses of CD4+ and CD8+ T lymphocytes by flow cytometry.
Lipid regulators of Pkh2 in Candida albicans, the protein kinase ortholog of mammalian PDK1.
Biondi et al., Frankfurt am Main, Germany. In Biochim Biophys Acta, Jan 2016
UNASSIGNED: Pkh is the yeast ortholog of the mammalian 3-phosphoinositide-dependent protein kinase 1 (PDK1).
Impaired PLP-dependent metabolism in brain samples from Huntington disease patients and transgenic R6/1 mice.
Cabiscol et al., Lleida, Spain. In Metab Brain Dis, Jan 2016
In a previous HD study, we identified several carbonylated proteins, including pyridoxal kinase and antiquitin, both of which are involved in the metabolism of pyridoxal 5´-phosphate (PLP), the active form of vitamin B6.
Negative prognostic value of high levels of intracellular poly(ADP-ribose) in non-small cell lung cancer.
Kroemer et al., Paris, France. In Ann Oncol, Dec 2015
BACKGROUND: Cisplatin-resistant non-small cell lung cancer (NSCLC) cells are often characterized by alterations in vitamin B-related metabolic processes, including the overexpression and hyperactivation of poly(ADP-ribose) polymerase 1 (PARP1) and the downregulation of pyridoxal kinase (PDXK), correlating with elevated apoptosis resistance.
Role of RNA-interference-induced zinc finger protein 139 suppression in gastric cancer cell sensitivity to chemotherapeutic agents.
Wang et al., Shijiazhuang, China. In Oncol Lett, Sep 2015
In the in vivo and in vitro experiments, the expression of pyridoxal kinase (PDXK) was upregulated, whereas the expression levels of annexin A2 (ANXA2) and fascin were downregulated following transfection.
Optimal Route for Human Umbilical Cord Blood-Derived Mesenchymal Stem Cell Transplantation to Protect Against Neonatal Hyperoxic Lung Injury: Gene Expression Profiles and Histopathology.
Park et al., Seoul, South Korea. In Plos One, 2014
Although the i.t. group received only one fourth of the number of MSCs that the i.v. group did, a significantly higher number of donor cell-derived red PKH 26 positivity were recovered in the i.t. group.
Activation of 5-HT4 receptors facilitates neurogenesis of injured enteric neurons at an anastomosis in the lower gut.
Nabekura et al., Kashihara, Japan. In J Smooth Muscle Res, 2014
We found that neurons differentiated from transplanted NSC (PKH [+]) and newborn enteric neurons differentiated from mobilized (host) NSC (YFP [+]) could be localized within the granulation tissue of anastomoses.
Depletion of yeast PDK1 orthologs triggers a stress-like transcriptional response.
Casamayor et al., Frankfurt am Main, Germany. In Bmc Genomics, 2014
BACKGROUND: Pkh proteins are the PDK1 orthologs in S. cerevisiae.
Effects of vitamin B6 metabolism on oncogenesis, tumor progression and therapeutic responses.
Kroemer et al., Paris, France. In Oncogene, 2013
Moreover, elevated levels of pyridoxal kinase (PDXK), the enzyme that converts pyridoxine and other vitamin B6 precursors into PLP, have been shown to constitute a good, therapy-independent prognostic marker in patients affected by non-small cell lung carcinoma (NSCLC).
Biomarkers in Parkinson's disease (recent update).
Ebadi et al., Netherlands. In Neurochem Int, 2013
Single-cell profiling of dopaminergic neurons has identified pyridoxal kinase and lysosomal ATPase as biomarker genes for PD prognosis.
Biomedical aspects of pyridoxal 5'-phosphate availability.
Contestabile et al., Roma, Italy. In Front Biosci (elite Ed), 2011
In humans, PLP is recycled from food and from degraded PLP-dependent enzymes in a salvage pathway requiring the action of pyridoxal kinase, pyridoxine 5'-phosphate oxidase and phosphatases.
Vitamin B(6) salvage enzymes: mechanism, structure and regulation.
Safo et al., Roma, Italy. In Biochim Biophys Acta, 2011
In animals, pyridoxal 5'-phosphate is recycled from food and from degraded B(6)-enzymes in a "salvage pathway", which essentially involves two ubiquitous enzymes: an ATP-dependent pyridoxal kinase and an FMN-dependent pyridoxine 5'-phosphate oxidase.
Protein oxidation in Huntington disease affects energy production and vitamin B6 metabolism.
Cabiscol et al., Lleida, Spain. In Free Radic Biol Med, 2010
The pyridoxal kinase showed decreased levels and was highly carbonylated in the gene-on mice
Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene.
Turnbull et al., München, Germany. In Ann Neurol, 2009
This study identified a DNA variant (rs2010795) in PDXK associated with an increased risk of PD in the German cohort This association was confirmed in the British and Italian cohorts individually and reached a combined value.
Kinetic and structural studies of the role of the active site residue Asp235 of human pyridoxal kinase.
Safo et al., Richmond, United States. In Biochem Biophys Res Commun, 2009
These results document the role of Asp235 in PL kinase activity.
Crystal Structure of human pyridoxal kinase: structural basis of M(+) and M(2+) activation.
Safo et al., Richmond, United States. In Protein Sci, 2007
The crystal structure of the MgATP complex also reveals Mg(2+) and Na(+) acting in tandem to anchor the ATP at the active site of pyridoxal kinase.
The genetic basis of human erythrocyte pyridoxal kinase activity variation.
Beutler et al., Los Angeles, United States. In Haematologica, 2006
A promoter mutation with potential erythroid-specific properties that could be the basis of a novel mechanism of controlling cell-specific decreased activity of an essential enzyme in erythrocytes.
Pyridoxal kinase: decreased activity in red blood cells of Afro-Americans.
Beutler et al., In Science, 1975
The mean pyridoxal kinase activity in red blood cells of American blacks was approximately 50 percent lower than that of American whites.
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