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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Pygopus homolog 1

PYGO1, pygoI
Top mentioned proteins: BCL9, pygopus 2, TCF, Histone, BCL9L
Papers on PYGO1
[Bioinformatic analysis of pygo1 gene in Homo sapiens].
Hao, Mudanjiang, China. In Zhejiang Da Xue Xue Bao Yi Xue Ban, 2014
OBJECTIVE: To analyze the structure and function of PYGO1 protein with bioinformatics.
Pygopus maintains heart function in aging Drosophila independently of canonical Wnt signaling.
Wu et al., Los Angeles, United States. In Circ Cardiovasc Genet, 2013
In the isoproterenol-induced hypertrophic mouse model, we show that Pygo1 protein levels are increased.
The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription.
Basler et al., Z├╝rich, Switzerland. In Development, 2013
The mouse genome encodes two Pygopus homologs, Pygo1 and Pygo2.
Exposure to Maternal Diabetes in Utero and DNA Methylation Patterns in the Offspring.
Dabelea et al., Aurora, United States. In Immunometabolism, 2013
Increased methylation of PYGO1 and CLN8 had the greatest relative mediation effect (RME = 87%, p=0.005 and RME=50%, p=0.01) on the impact of exposure to maternal diabetes in utero on VCAM-1 levels in the offspring.
Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor.
Bienz et al., Cambridge, United Kingdom. In J Mol Biol, 2010
Although histone-binding residues are identical between the two human Pygo paralogs, we show here that Pygo2 complexes exhibit slightly higher binding affinities for methylated histone H3 tail peptides than Pygo1 complexes.
Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer.
Brenner et al., Heidelberg, Germany. In Carcinogenesis, 2010
This population-based case-control study, including 1795 CRC cases and 1805 controls, investigates the association between common, putative functional polymorphisms in DNFA5, HIF1A, NDRG1, PYGO1, SFRP2, SFRP4, WISP1 and WISP3 genes and CRC risk.
Low concentrations of resveratrol inhibit Wnt signal throughput in colon-derived cells: implications for colon cancer prevention.
Holcombe et al., Irvine, United States. In Mol Nutr Food Res, 2008
Low concentrations of resveratrol significantly decreased the amount and proportion of beta-catenin in the nucleus in RKO (p = 0.002) and reduced the expression of lgs and pygoI, regulators of beta-catenin localization, in all cells lines.
Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex.
GeneRIF
Bienz et al., Cambridge, United Kingdom. In Mol Cell, 2008
Data show that human and Drosophila Pygo PHD fingers associate with their cognate HD1 domains from BCL9/Legless to bind specifically to the histone H3 tail methylated at lysine 4 (H3K4me).
Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin.
Grosschedl et al., Freiburg, Germany. In Mol Cell Biol, 2008
However, the presumed general functions of Pygopus and BCL9, which has been proposed to act as a scaffolding protein for Pygopus, have been challenged by the rather specific and modest developmental defects of targeted inactivations of both the Pygo1 and the Pygo2 genes.
Crystal structure analysis of the PHD domain of the transcription co-activator Pygopus.
GeneRIF
Yokoyama et al., Yokohama, Japan. In J Mol Biol, 2007
These results suggest that the Pygopus1 plant homeodomain (PHD) dimerization is functionally important for Lgs/Bcl9 recognition as well as for the regulation of the Wnt/beta-catenin signaling pathway.
Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development.
GeneRIF
Potter et al., Cincinnati, United States. In Bmc Biol, 2006
In mammals, the Pygo1/Pygo2 genes are not absolutely required for canonical Wnt signaling in most developing systems, but rather function as quantitative transducers, or modulators, of Wnt signal intensity
Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades.
Review
Katoh et al., Tokyo, Japan. In Cancer Biol Ther, 2006
Nuclear beta-catenin is complexed with TCF/LEF, Legless (BCL9 or BCL9L) and PYGO (PYGO1 or PYGO2) to activate transcription of CCND1, MYC, FGF18 and FGF20 genes for the cell-fate determination.
Comparative genomics on FGF16 orthologs.
Katoh et al., Japan. In Int J Mol Med, 2005
Because nuclear complex consisting of TCF/LEF (TCF1, TCF3, TCF4 or LEF1), beta-catenin, PYGO (PYGO1 or PYGO2) and Legless (BCL9 or BCL9L) binds to the TCF/LEF-binding site to up-regulate WNT/beta-catenin target genes, FGF16 gene was characterized as the evolutionarily conserved target of the WNT/beta-catenin signaling pathway, just like FGF18 and FGF20 genes.
Pygopus residues required for its binding to Legless are critical for transcription and development.
GeneRIF
Bienz et al., Cambridge, United Kingdom. In J Biol Chem, 2004
identifed conserved residues within Pygopus that are required for binding to Legless in vitro and for their activity in transcription [pygo1]
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