gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

PX domain containing serine/threonine kinase

PXK, PX domain containing serine/threonine kinase
PXK binds to the Na,K-ATPase beta-1 (ATP1B1; MIM 182330) and beta-3 (ATP1B3; MIM 601867) subunits and modulates both Na,K-ATPase enzymatic and ion pump activities (Mao et al., 2005 [PubMed 16135750]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Kir2.1, BANK, STAT4, MECP2, KIAA1542
Papers on PXK
Genome-wide search followed by replication reveals genetic interaction of CD80 and ALOX5AP associated with systemic lupus erythematosus in Asian populations.
New
Yang et al., Hong Kong, Hong Kong. In Ann Rheum Dis, May 2015
Genetic interactions between BLK (rs13277113) and DDX6 (rs4639966), and between TNFSF4 (rs844648) and PXK (rs6445975) were also observed in both GWAS data sets.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
New
Colwill et al., Toronto, Canada. In Sci Signal, May 2015
Two of these kinases that were classified as resistors were PX domain-containing serine/threonine kinase (PXK) and AP2-associated kinase 1 (AAK1), which promote receptor endocytosis and may enable cells to resist TRAIL-induced apoptosis by enhancing endocytosis of the TRAIL receptors.
Association between KIAA0319L, PXK and JAZF1 gene polymorphisms and unexplained recurrent pregnancy loss in Chinese Han couples.
New
Chen et al., Jinan, China. In Reprod Biomed Online, Mar 2015
KIAA0319L, PXK and JAZF1 gene polymorphisms were investigated to determine whether they conferred susceptibility to unexplained recurrent pregnancy loss (URPL) in a group of Chinese Han patients.
PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6.
New
Kozyrev et al., Uppsala, Sweden. In Ann Rheum Dis, Mar 2015
OBJECTIVES: To perform fine mapping of the PXK locus associated with systemic lupus erythematosus (SLE) and study functional effects that lead to susceptibility to the disease.
Association of systemic lupus erythematosus susceptibility genes with IgA nephropathy in a Chinese cohort.
Zhang et al., Beijing, China. In Clin J Am Soc Nephrol, 2014
CFH (P=8.41 × 10(-6)), HLA-DRA (P=4.91 × 10(-6)), HLA-DRB1 (P=9.46 × 10(-9)), PXK (P=3.62 × 10(-4)), BLK (P=9.32 × 10(-3)), and UBE2L3 (P=4.07 × 10(-3)) were identified as shared genes between IgAN and SLE.
Systemic Sclerosis is a Complex Disease Associated Mainly with Immune Regulatory and Inflammatory Genes.
Zhou et al., Houston, United States. In Open Rheumatol J, 2013
These genes include HLA genes, STAT4, CD247, TBX21, PTPN22, TNFSF4, IL23R, IL2RA, IL-21, SCHIP1/IL12A, CD226, BANK1, C8orf13-BLK, PLD4, TLR-2, NLRP1, ATG5, IRF5, IRF8, TNFAIP3, IRAK1, NFKB1, TNIP1, FAS, MIF, HGF, OPN, IL-6, CXCL8, CCR6, CTGF, ITGAM, CAV1, MECP2, SOX5, JAZF1, DNASEIL3, XRCC1, XRCC4, PXK, CSK, GRB10, NOTCH4, RHOB, KIAA0319, PSD3 and PSOR1C1.
Lupus risk variants in the PXK locus alter B-cell receptor internalization.
Kottyan et al., Cincinnati, United States. In Front Genet, 2013
Genome wide association studies have identified variants in PXK that confer risk for humoral autoimmune diseases, including systemic lupus erythematosus (SLE or lupus), rheumatoid arthritis and more recently systemic sclerosis.
Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: a meta-analysis.
Song et al., Seoul, South Korea. In Inflamm Res, 2012
OBJECTIVE: The aim of this study was to determine whether phox homology domain containing serine/threonine kinase (PXK) and tyrosine kinase 2 (TYK2) confer susceptibility to systemic lupus erythematosus (SLE).
Different genetic effect of PXK on systemic lupus erythematosus in the Korean population.
GeneRIF
Bae et al., Seoul, South Korea. In Rheumatol Int, 2012
The association of PXK rs6445975 with systemic lupus erythematosus that was previously observed in Caucasians was not replicated in Koreans or in Hong Kong Chinese.
Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study.
Sawalha et al., Oklahoma City, United States. In Arthritis Rheum, 2011
The loci examined included PTPN22, FCGR2A, TNFSF4, STAT4, CTLA4, PDCD1, PXK, BANK1, MSH5 (HLA region), CFB (HLA region), C8orf13-BLK region, MBL2, KIAA1542, ITGAM, and MECP2/IRAK1.
Polymorphisms of PXK are associated with autoantibody production, but not disease risk, of systemic lupus erythematosus in Chinese mainland population.
Wan et al., Shenzhen, China. In Lupus, 2011
The genetic variation in the PXK gene was found to associate with SLE in Caucasian populations.
What can we learn from genetic studies of systemic lupus erythematosus? Implications of genetic heterogeneity among populations in SLE.
Review
Bae et al., Seoul, South Korea. In Lupus, 2010
In addition, there are also several genes and loci that could not be assigned into previous known pathways (KIAA1542, PXK, XKR6, ATG5, etc), providing possible novel mechanisms in SLE.
Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking.
GeneRIF
Hirata et al., Fukuoka, Japan. In Mol Cell Biol, 2010
These results indicate that PXK plays a critical role in epidermal growth factor receptor trafficking through modulating ligand-induced ubiquitination of the receptor.
Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors.
Gonzalez et al., Santiago de Compostela, Spain. In Arthritis Rheum, 2009
METHODS: A characteristic single-nucleotide polymorphism (SNP) in each of 9 genetic factors, ITGAM (rs1143679), C8orf13-BLK (rs13277113), TYK2 (rs2304256), 1q25.1 (rs10798269), PXK (rs6445975), KIAA1542 (rs4963128), MECP2 (rs17435), BANK1 (rs17266594), and LY9 (rs509749), was studied in 1,635 patients with RA and 1,906 control subjects from Spain.
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
Impact
GeneRIF
Kelly et al., Oklahoma City, United States. In Nat Genet, 2008
study presents four new regions having genetic associations with systemic lupus erythematosus in women of European descent: ITGAM, KIAA1542, PXK and rs10798269
MONaKA, a novel modulator of the plasma membrane Na,K-ATPase.
GeneRIF
Levitan et al., Philadelphia, United States. In J Neurosci, 2005
MONaKA modulates brain Na,K-ATPase by binding tightly to its beta1 and beta3 subunits, and may thereby participate in the regulation of electrical excitability and synaptic transmission [MONaKA]
share on facebooktweetadd +1mail to friends