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Aminopeptidase puromycin sensitive

puromycin-sensitive aminopeptidase, MP100, NPEPPS
This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: aminopeptidase, Enkephalin, ACID, HAD, fibrillin-1
Papers using puromycin-sensitive aminopeptidase antibodies
PANTHER: a library of protein families and subfamilies indexed by function
Jackson George R. et al., In Human Molecular Genetics, 2002
... Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAUP301L double transgenic mice ...
Papers on puromycin-sensitive aminopeptidase
Supplementation of metabolizable protein during late gestation and fetal number impact ewe organ mass, maternal serum hormone and metabolite concentrations, and conceptus measurements.
Vonnahme et al., Fargo, United States. In Domest Anim Endocrinol, Sep 2015
UNASSIGNED: To examine the effects of maternal metabolizable protein (MP) supplementation during late gestation on serum hormone and metabolites and organ masses, multiparous ewes (n = 45) carrying singletons or twins were allotted randomly (within pregnancy group) to 1 of 3 treatments: 60% (MP60), 80% (MP80), or 100% (MP100) of MP requirements.
Plasma peptidases as prognostic biomarkers in patients with first-episode psychosis.
Seco et al., Spain. In Psychiatry Res, Sep 2015
We observed significant differences in aminopeptidase B (APB), aminopeptidase N (APN) and dipeptidyl peptidase IV (DPPIV), but not in puromycin-sensitive aminopeptidase (PSA), prolyl endopeptidase (PEP), cysteine aminopeptidase (Cys-AP), aspartate aminopeptidase (Asp-AP), glutamate aminopeptidase (Glu) or piroglutamate aminopeptidase (PGI) in these patients compared to controls, and also a progressive increase in plasma activity, correlated to changes in scores on clinical scales, Global Assessment of Functioning scale (GAF) and Hamilton Depression Rating Scale (HDRS), at 1 month of follow-up.
Maternal metabolizable protein restriction during late gestation on uterine and umbilical blood flows and maternal and fetal amino acid concentrations near term in sheep.
Vonnahme et al., Fargo, United States. In Anim Reprod Sci, Jul 2015
To examine the effects of maternal metabolizable protein (MP) restriction during late gestation on uterine and umbilical blood flows, conceptus size, and amino acid concentrations in the uterine and umbilical vessels, 11 ewes with singleton pregnancies were assigned to one of three isocaloric diets formulated to provide 60% of MP (MP60), 80% of MP (MP80), or 100% of MP (MP100) requirements from days 100 to 130 of gestation.
Revisiting MHC genes in spondyloarthritis.
Garchon et al., Boulogne-Billancourt, France. In Curr Rheumatol Rep, Jun 2015
Interestingly, some of those new genes, such as ERAP1, ERAP2, and NPEPPS, code for aminopeptidases that are involved in MHC class I presentation and were shown to interact with HLA-B27.
Altered Activity and Expression of Cytosolic Peptidases in Colorectal Cancer.
Larrinaga et al., Leioa, Spain. In Int J Med Sci, 2014
METHODS: The activity and mRNA levels of puromycin-sensitive aminopeptidase (PSA), aminopeptidase B (APB) and pyroglutamyl-peptidase I (PGI) were measured by fluorimetric and quantitative RT-PCR methods in colorectal mucosa and tumor tissues and plasma samples from CRC patients (n=81).
Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases.
Brown et al., Australia. In Genes Immun, 2014
Endosplasmic reticulum aminopeptidase 1 (ERAP1), endoplasmic reticulum aminopeptidase 2 (ERAP2) and puromycin-sensitive aminopeptidase (NPEPPS) are key zinc metallopeptidases that belong to the oxytocinase subfamily of M1 aminopeptidase family.
Proteomic analysis of reproduction proteins involved in litter size from porcine placenta.
Choi et al., Taejŏn, South Korea. In Biosci Biotechnol Biochem, 2014
Of the dominantly expressed proteins, we chose prolificacy-related proteins such as puromycin-sensitive aminopeptidase (PSA) and retinol-binding protein 4 (RBP4).
Collaboration within the M1 aminopeptidase family promotes reproductive success in Caenorhabditis elegans.
Trzepacz et al., Murray, United States. In Dev Genes Evol, 2014
Mutations of the puromycin-sensitive aminopeptidase (Psa) orthologs of flies, mice, and plants result in meiotic errors and reduced embryonic viability.
Positioning of aminopeptidase inhibitors in next generation cancer therapy.
Peters et al., Amsterdam, Netherlands. In Amino Acids, 2014
This review focuses on the function and subcellular location of five key aminopeptidases (aminopeptidase N, leucine aminopeptidase, puromycin-sensitive aminopeptidase, leukotriene A4 hydrolase and endoplasmic reticulum aminopeptidase 1/2) and their association with different diseases, in particular cancer and their current position as target for therapeutic intervention by aminopeptidase inhibitors.
Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity.
Crowther et al., Cambridge, United Kingdom. In Biochim Biophys Acta, 2013
In an unbiased genetic screen, we identified puromycin-sensitive aminopeptidase (PSA) as a potent suppressor of Aβ toxicity in a Drosophila model system.
Development of 2-thioxoquinazoline-4-one derivatives as dual and selective inhibitors of dynamin-related protein 1 (Drp1) and puromycin-sensitive aminopeptidase (PSA).
Hashimoto et al., Tokyo, Japan. In Chem Pharm Bull (tokyo), 2013
An established inhibitor of dynamin-related protein 1 (Drp1), 3-(2,4-dichloro-5-methoxyphenyl)-2-thioxoquinazoline-4-one (mdivi-1), was recently reported also to show potent puromycin-sensitive aminopeptidase (PSA)-inhibitory activity.
[Alzheimer disease and tau protein].
Takeda et al., Ōsaka, Japan. In Rinsho Shinkeigaku, 2011
Among several proteases, puromycin-sensitive aminopeptidase (PSA) was found as a predominant regulator of degradation of tau protein.
Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice.
Karsten et al., United States. In Hum Mol Genet, 2011
Elevation of NPEPPS activity blocks accumulation of hyperphosphorylated TAU protein and slows down the progression of Alzheimer's disease.
The role of multifunctional M1 metallopeptidases in cell cycle progression.
Peer, West Lafayette, United States. In Ann Bot, 2011
In animals, human puromycin-sensitive aminopeptidase (PSA) acts during mitosis and perhaps meiosis, while the insect homologue puromycin-sensitive aminopeptidase (PAM-1) is required for meiotic and mitotic exit; the remaining human M1 family members appear to play a direct or indirect role in mitosis/cell proliferation.
Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy.
Rubinsztein et al., Cambridge, United Kingdom. In Hum Mol Genet, 2011
findings show that by promoting autophagic protein clearance, PSA helps protect against accumulation of aggregation-prone proteins and proteotoxicity
Involvement of puromycin-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) mutant tau.
Takeda et al., Suita, Japan. In Psychogeriatrics, 2009
attenuated proteolysis of FTDP-17 mutant tau may be explained by increased phosphorylation levels, resulting in resistance to proteolysis.
Cobalt chloride-induced downregulation of puromycin-sensitive aminopeptidase suppresses the migration and invasion of PC-3 cells.
Kim et al., Chŏnju, South Korea. In J Microbiol Biotechnol, 2009
PSA gene was downregulated in PC-3 cells that were treated with CoCl(2). PSA is involved in the proliferation, migration, and invasion of PC-3 cells, which are important determinants of metastasis, via a mechanism that involves MMP-9 modulation.
Brain-specific aminopeptidase: from enkephalinase to protector against neurodegeneration.
Hui, United States. In Neurochem Res, 2007
Recently, puromycin-sensitive aminopeptidase (PSA) was identified as a modifier of tau-induced neurodegeneration.
Analysis of conserved residues of the human puromycin-sensitive aminopeptidase.
Hersh et al., Lexington, United States. In Peptides, 2003
ApPS Y394F exhibited a 3.3-fold lower affinity for RB-3014, a transition state inhibitor, indicating that Tyr394 is involved in transition state stabilization
Two new proteases in the MHC class I processing pathway.
Schild et al., Tübingen, Germany. In Nat Immunol, 2000
By using specific selective criteria we purified two cytosolic proteolytic activities, puromycin-sensitive aminopeptidase and bleomycin hydrolase.
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