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Purine-rich element binding protein G
purG, Purgamma, Purga, PURG-B
The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from
Franklin et al., Iowa City, United States. In J Biol Inorg Chem, 2006
Binding selection from a library of randomized 8-mer DNA oligonucleotide sequences identified one target family for CaP5b [5'-pur-T-pur-G-(G/C)-3'], and two target sites for CaP3W [5'-(A/T)-G-G-G-(T/C)-3' and 5'-A-T-(G/T)-T-G-3']. Circular dichroism studies indicate that unlike EuP3W, EuP5b is poorly folded in the absence of DNA.
Wang et al., Beijing, China. In Sci China C Life Sci, 1997
Salmonella typhimurium 5 phosphoribosylformylglycinamide (FGAR) amidotransferase encoded bypurG gene catalyzes the conversion of FGAR to formylglycinamide ribonucleotide (FGAM) in the presence of glu- tamine and ATP for thede novo purine nucleotide biosynthesis.purG
Tang et al., Beijing, China. In Yi Chuan Xue Bao, 1992
purD:: MudJ (lacZ Kanr) and purG:: MudJ (lacZ Kanr) were used as starting strains Both strains were mutagenized by NTG, and derepressed mutants were selected on the MacConkey plate containing an excess of adenosine (2mmol/L).