Cytoplasmic polyadenylation in mammalian oocyte maturation.
Davis, United States. In Wiley Interdiscip Rev Rna, Jan 2016
The cytoplasmic polyadenylation (CP) element, Pumilio binding element, and hexanucleotide polyadenylation signal are among the best understood motifs involved in CP, and translational regulation of stored transcripts as their binding partners have been relatively well-characterized.
Target selection by natural and redesigned PUF proteins.
Madison, United States. In Proc Natl Acad Sci U S A, Jan 2016
Pumilio/fem-3 mRNA binding factor (PUF) proteins bind RNA with sequence specificity and modularity, and have become exemplary scaffolds in the reengineering of new RNA specificities.
Bespoke RNA recognition by Pumilios.
Leeds, United Kingdom. In Biochem Soc Trans, Nov 2015
Pumilio is an RNA-binding protein originally identified in Drosophila, with a Puf domain made up of eight Puf repeats, three helix bundles arranged in a rainbow architecture, where each repeat recognizes a single base of the RNA-binding sequence.
Neural-specific elongation of 3' UTRs during Drosophila development.
Berkeley, United States. In Proc Natl Acad Sci U S A, 2011
Data show that the extended 3' UTR sequences are selectively expressed in neural tissues and contain putative recognition motifs for the translational repressor, Pumilio, which also exhibits the 3' lengthening phenomenon.
Pumilio turns on microRNA function.
In Nat Cell Biol, 2010
Pumilio proteins PUM1 and PUM2 are shown to regulate microRNA-dependent gene silencing by induction of a conformational switch in the 3' untranslated region of p27 mRNA.