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BCL2 binding component 3

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: p53, Bax, bcl-2, PrP, CAN
Papers using PUMA antibodies
Efficient RNA interference in patientśacute lymphoblastic leukemia cells amplified as xenografts in mice
Jeremias I et al., In Cell Death & Disease, 2011
... , anti COX IV, anti Endonuclease G, anti OMI/HtrA2, anti PUMA and anti Survivin from Cell Signaling Technology Inc ...
DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence
Swarbrick Alexander, In PLoS ONE, 2007
... Rabbit anti-PUMA was purchased from ProSci Incorporated (Poway, CA) ...
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
Barillé-Nion Sophie et al., In Breast Cancer Research : BCR, 2004
... Antibodies against cleaved Notch1 (N1ICD) were purchased from Cell Signaling (Saint Quentin en Yvelines, France); Puma, from Epitomics (Nanterre, France); and Bim ...
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
Pereira T S et al., In Cell Death & Disease, 1994
... Cell Signaling Technology), anti-Bim (1:500, 559685, BD Transduction Laboratories), anti-Bax (1:500, 554106, BD Transduction Laboratories), anti-PUMA (1:200, sc-28226, Santa Cruz Biotechnology, Santa Cruz, CA, USA), ...
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Papers on PUMA
Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance.
Nijnik et al., Montréal, Canada. In Cell Death Differ, Feb 2016
Mechanistically, we find that the MYSM1 protein associates with p53 and colocalizes to promoters of classical p53-target genes Bbc3/PUMA (p53 upregulated modulator of apoptosis) and Cdkn1a/p21.
ER Stress-Mediated Upregulation of miR-29a Enhances Sensitivity to Neuronal Apoptosis.
Prehn et al., Dublin, Ireland. In Eur J Neurosci, Feb 2016
We previously identified the Bcl-2 homology domain 3 (BH3)-Only Protein Puma as a mediator of ER stress-induced apoptosis in neurons.
PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia.
Curtis et al., Melbourne, Australia. In Cell Death Differ, Feb 2016
To further understand this surprising result, we examined the role of p53 and its pro-apoptotic effectors, PUMA and NOXA in NHD13 mice.
Cell death induced by endoplasmic reticulum stress.
Muñoz-Pinedo et al., l'Hospitalet de Llobregat, Spain. In Febs J, Dec 2015
These proteins aim to restore homeostasis, but they can also induce cell death, which has been shown to occur by necroptosis and, more commonly, through the regulation of Bcl-2 family proteins (Bim, Noxa and Puma) that leads to mitochondrial apoptosis.
An interconnected hierarchical model of cell death regulation by the BCL-2 family.
Cheng et al., Kettering, United States. In Nat Cell Biol, Oct 2015
The BH3-only molecules (BH3s) promote apoptosis by either activating BAX-BAK or inactivating anti-apoptotic members.
Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment.
Kaufmann et al., Rochester, United States. In Biochim Biophys Acta, Jul 2015
Thirty years later we now understand that anti-apoptotic Bcl-2 family members modulate the intrinsic apoptotic pathway by binding and neutralizing the mitochondrial permeabilizers Bax and Bak as well as a variety of pro-apoptotic proteins, including the cellular stress sensors Bim, Bid, Puma, Bad, Bmf and Noxa.
Cisplatin resistance in germ cell tumours: models and mechanisms.
Honecker et al., Hamburg, Germany. In Andrology, 2015
Secondly, GCT, especially embryonal carcinoma (EC) cells, show a hypersensitive apoptotic response to DNA damage, which activates p53, and leads to up-regulation of the pro-apoptotic factors Noxa, Puma and Fas in non-resistant EC.
Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge.
Colucci et al., Boston, United States. In J Am Heart Assoc, 2014
Myocardial dysfunction in hearts of cardiac LKB1 mice fed the high-fat, high-sucrose diet was associated with evidence of increased apoptosis and apoptotic signaling via caspase 3 and p53/PUMA (p53 upregulated modulator of apoptosis) and more severe mitochondrial dysfunction.
C-terminal binding proteins: central players in development and disease.
Linseman et al., In Biomol Concepts, 2014
More recent studies have demonstrated a critical function for CtBPs in the transcriptional repression of pro-apoptotic genes such as Bax, Puma, Bik, and Noxa.
AS-IV protects against kidney IRI through inhibition of NF-κB activity and PUMA upregulation.
Ai et al., Qingdao, China. In Int J Clin Exp Med, 2014
At 6 h after reperfusion, the inflammatory cytokines and renal function was assessed and NF-κB activity and PUMA expression was detected.
Importance of proapoptotic protein PUMA in cell radioresistance.
Rezáčová et al., Hradec Králové, Czech Republic. In Folia Biol (praha), 2013
p53 activation leads to an increase in the Bcl-2 family pro-apoptotic protein PUMA level.
Epidermal growth factor regulates hematopoietic regeneration after radiation injury.
Chute et al., Durham, United States. In Nat Med, 2013
Mechanistically, EGF reduced radiation-induced apoptosis of HSCs and mediated this effect through repression of the proapoptotic protein PUMA.
Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.
Möröy et al., Montréal, Canada. In Cancer Cell, 2013
Specifically, Gfi1 restricts p53 activity and expression of proapoptotic p53 targets such as Bax, Noxa (Pmaip1), and Puma (Bbc3).
ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation.
Simon et al., Philadelphia, United States. In Cancer Cell, 2012
Using MYCN-amplified neuroblastoma as a model, we identify PUMA, NOXA, and TRB3 as executors of Gln-starved cells.
The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens.
Strasser et al., Australia. In Immunity, 2012
Although the proapoptotic BH3-only protein, Bim, is required for deletion of autoreactive thymocytes, Bim-deficient mice do not succumb to extensive organ-specific autoimmune disease.
JNK- and Akt-mediated Puma expression in the apoptosis of cisplatin-resistant ovarian cancer cells.
Wei et al., Chengdu, China. In Biochem J, 2012
The JNK-potentiated Akt/FoxO3a and JNK-mediated c-Jun pathways co-operatively trigger Puma expression, which determines the threshold for overcoming chemoresistance in ovarian cancer cells.
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α.
Hetz et al., Santiago, Chile. In Embo J, 2012
The authors identified the BCL-2 family member PUMA as a novel IRE1alpha interactor. Immun oprecipitation experiments confirmed this interaction and further detected the association of IRE1alpha with BIM, another BH3-only protein.
In vitro binding properties of tumor suppressor p53 with PUMA and NOXA.
Jang et al., Pusan, South Korea. In Biochem Biophys Res Commun, 2012
these study suggested that the four mutations lowered the stability of the p53 DBD domain and induced aggregation of structurally destabilized p53, and thus disrupted the p53-PUMA/NOXA interaction.
Critical role of p53 upregulated modulator of apoptosis in benzyl isothiocyanate-induced apoptotic cell death.
Singh et al., Pittsburgh, United States. In Plos One, 2011
Bim-independent apoptosis by BITC in cancer cells is mediated by PUMA
[Small molecules--principal participants of pathogenesis of rheumatoid arthritis].
Dubikov et al., In Klin Med (mosk), 2011
[review] Small molecules like p21 and PUMA may play a role in the pathogenesis of rheumatoid arthritis.
More papers using PUMA antibodies
The Toxicity of Poisons Applied Jointly
Borst J et al., In Cell Death & Disease, 1938
... For Dox-inducible, stable expression in J16 cells, HA-tagged Bid, Bim, Noxa and Puma cDNA′s were cloned into the lentiviral vector pLVX-Tight (Clontech, Mountain View, CA, USA) ...
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